HitPredict

Interactor 1: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Interactor 2: PKHA7 (Q6IQ23)
Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7)
Gene: PLEKHA7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	28877994
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 654 Hs			1 1121
+	Hs
		504247 HSP7C_HUMAN (26-637): 0: 916: 66.02		PKHA7_HUMAN (1-1121): 2.81e-180: 560: 100.00
+	Hs
		504250 HSP7C_HUMAN (26-637): 0: 916: 66.02		NIPBL_HUMAN (210-1111): 1.78e-57: 220: 12.13
+	Hs
		504388 HSP7C_HUMAN (26-637): 0: 916: 66.02		RHG24_HUMAN (163-802): 1.1e-49: 191: 13.32
+	Hs
		502315 BIP_HUMAN (19-654): 0: 914: 100.00		RHG24_HUMAN (163-802): 1.1e-49: 191: 13.32
+	Hs
		504792 HSP7C_HUMAN (26-637): 0: 916: 66.02		SMUF1_HUMAN (4-213): 3.11e-48: 187: 18.58
+	Hs
		502570 BIP_HUMAN (19-654): 0: 914: 100.00		SMUF1_HUMAN (4-213): 3.11e-48: 187: 18.58
+	Hs
		503764 HSP7C_HUMAN (26-637): 0: 916: 66.02		AFAD_HUMAN (329-1063): 1.33e-45: 182: 11.19
+	Hs
		501878 BIP_HUMAN (19-654): 0: 914: 100.00		AFAD_HUMAN (329-1063): 1.33e-45: 182: 11.19
+	Hs
		125115 HSP7C_HUMAN (26-637): 0: 916: 66.02		WWP2_HUMAN (8-203): 2.64e-43: 173: 24.39
+	Hs
		125114 BIP_HUMAN (19-654): 0: 914: 100.00		WWP2_HUMAN (8-203): 2.64e-43: 173: 24.39
+	Hs
		871517 HSP72_HUMAN (25-636): 0: 905: 64.51		AFAD_HUMAN (329-1063): 1.33e-45: 182: 11.19
+	Hs
		504760 HSP7C_HUMAN (26-637): 0: 916: 66.02		PKHA4_HUMAN (113-465): 8.31e-38: 154: 28.84
+	Hs
		502562 BIP_HUMAN (19-654): 0: 914: 100.00		PKHA4_HUMAN (113-465): 8.31e-38: 154: 28.84
+	Hs
		871786 HSP72_HUMAN (25-636): 0: 905: 64.51		PKHA4_HUMAN (113-465): 8.31e-38: 154: 28.84
+	Hs
		502449 BIP_HUMAN (19-654): 0: 914: 100.00		NED4L_HUMAN (59-486): 2.54e-26: 118: 12.47
+	Hs
		504871 HSP7C_HUMAN (26-637): 0: 916: 66.02		WWOX_HUMAN (9-115): 8.02e-20: 95.4: 29.91
+	Hs
		504580 HSP7C_HUMAN (26-637): 0: 916: 66.02		ITCH_HUMAN (40-305): 7.41e-17: 88.1: 14.49
+	Sc
		560672 BIP_YEAST (22-638): 0: 798: 68.82		RSP5_YEAST (29-320): 3.05e-17: 89.3: 13.99