HitPredict

Interactor 1: ODPB (P11177)
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1)
Gene: PDHB

Interactor 2: PDK1 (Q15118)
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1)
Gene: PDK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	29568061, 26186194, 28514442, 33961781
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005759 - mitochondrial matrix GO:0006006 - glucose metabolic process
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 359 Hs			1 436
+	Hs
		602399 ODBB_HUMAN (2-358): 1.28e-120: 355: 31.76		PDK1_HUMAN (1-436): 0: 674: 100.00
+	Hs
		505831 ODPB_HUMAN (1-359): 9.81e-148: 422: 100.00		PDK2_HUMAN (37-436): 0: 604: 69.25
+	Hs
		505832 ODPB_HUMAN (1-359): 9.81e-148: 422: 100.00		PDK3_HUMAN (42-435): 0: 589: 68.61
+	Hs
		81547 ODPB_HUMAN (1-359): 9.81e-148: 422: 100.00		B7Z207_HUMAN (156-436): 1.39e-167: 473: 100.00
+	Mm
		222988 ODPB_MOUSE (1-359): 1.82e-145: 417: 93.59		BCKD_MOUSE (1-398): 3.29e-160: 459: 28.27
+	Rn
		728437 ODBB_RAT (2-358): 1.5e-119: 352: 31.52		BCKD_RAT (1-398): 3.96e-161: 462: 28.27