Protein: CDK16
Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1)

Gene: CDK16
Organism: Homo sapiens
Interactions: 136
UniProt ID: Q00536

Gene Ontology (top 5):
GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
GO:0004674 - protein serine/threonine kinase activity
GO:0004693 - cyclin-dependent protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

960388

CCYL1
Cyclin-Y-like protein 1

7

9

Small-scale

0.968

High

960390

CCNY
Cyclin-Y

4

9

Small-scale

0.915

High

215887

ZBT14
Zinc finger and BTB domain-containing protein 14

3

1

High-throughput

0.871

High

826258

CDK8
Cyclin-dependent kinase 8

3

19

High-throughput

0.861

High

960355

CDK17
Cyclin-dependent kinase 17

3

16

High-throughput

0.861

High

960427

CILK1
Serine/threonine-protein kinase ICK

3

16

High-throughput

0.861

High

960358

CDK18
Cyclin-dependent kinase 18

3

16

High-throughput

0.847

High

586686

CSK22
Casein kinase II subunit alpha'

2

19

High-throughput

0.811

High

625366

CDK2
Cyclin-dependent kinase 2

2

16

High-throughput

0.811

High

804107

CDN1B
Cyclin-dependent kinase inhibitor 1B

2

20

High-throughput

0.811

High

931590

CSK2B
Casein kinase II subunit beta

2

1

High-throughput

0.811

High

960269

CDK5
Cyclin-dependent kinase 5

2

16

Small-scale

0.799

High

673143

CCND3
G1/S-specific cyclin-D3

2

20

High-throughput

0.783

High

350078

RASK
GTPase KRas

2

12

High-throughput

0.754

High

960366

CD5R1
Cyclin-dependent kinase 5 activator 1

1

7

Small-scale

0.740

High

960375

RHG21
Rho GTPase-activating protein 21

2

3

High-throughput

0.737

High

904446

1433G
14-3-3 protein gamma

5

20

Small-scale

0.720

High

749378

BRCA1
Breast cancer type 1 susceptibility protein

5

12

Small-scale

0.710

High

960357

1433F
14-3-3 protein eta

4

20

Small-scale

0.701

High

909448

1433E
14-3-3 protein epsilon

4

10

High-throughput

0.699

High

926924

1433Z
14-3-3 protein zeta/delta

4

20

Small-scale

0.692

High

176432

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

1

High-throughput

0.691

High

934099

CSK21
Casein kinase II subunit alpha

1

19

High-throughput

0.691

High

960410

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

1

15

High-throughput

0.691

High

683269

1433B
14-3-3 protein beta/alpha

3

20

High-throughput

0.675

High

941681

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

4

Small-scale

0.647

High

64008

SPDE4
Speedy protein E4

1

17

High-throughput

0.618

High

166553

DCLK1
Serine/threonine-protein kinase DCLK1

1

6

High-throughput

0.618

High

216921

KIF1C
Kinesin-like protein KIF1C

1

4

High-throughput

0.618

High

227182

PRKN
E3 ubiquitin-protein ligase parkin

1

10

High-throughput

0.618

High

230862

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

11

High-throughput

0.618

High

348618

RASN
GTPase NRas

1

13

High-throughput

0.618

High

433698

LYN
Tyrosine-protein kinase Lyn

1

15

High-throughput

0.618

High

507952

FGFR1
Fibroblast growth factor receptor 1

1

17

High-throughput

0.618

High

673470

MPIP2
M-phase inducer phosphatase 2

1

18

High-throughput

0.618

High

876358

AFAD
Afadin

1

11

High-throughput

0.618

High

895041

RAB2A
Ras-related protein Rab-2A

1

2

High-throughput

0.618

High

914011

RB11A
Ras-related protein Rab-11A

1

3

High-throughput

0.618

High

915610

RHOB
Rho-related GTP-binding protein RhoB

1

11

High-throughput

0.618

High

960360

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

2

High-throughput

0.618

High

960363

MELK
Maternal embryonic leucine zipper kinase

1

2

High-throughput

0.618

High

960364

ZN638
Zinc finger protein 638

1

6

High-throughput

0.618

High

960365

KIF14
Kinesin-like protein KIF14

1

5

High-throughput

0.618

High

960367

RAB35
Ras-related protein Rab-35

1

1

High-throughput

0.618

High

960369

RHOH
Rho-related GTP-binding protein RhoH

1

12

High-throughput

0.618

High

960373

LARP7
La-related protein 7

1

19

High-throughput

0.618

High

960376

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

10

High-throughput

0.618

High

960382

PKHA7
Pleckstrin homology domain-containing family A member 7

1

14

High-throughput

0.618

High

960386

PHLB2
Pleckstrin homology-like domain family B member 2

1

18

High-throughput

0.618

High

960387

KSR1
Kinase suppressor of Ras 1

1

10

High-throughput

0.618

High

960396

SRS12
Serine/arginine-rich splicing factor 12

1

4

High-throughput

0.618

High

960405

TESK2
Dual specificity testis-specific protein kinase 2

1

12

High-throughput

0.618

High

960411

PKHA4
Pleckstrin homology domain-containing family A member 4

1

10

High-throughput

0.618

High

960413

PKHA5
Pleckstrin homology domain-containing family A member 5

1

12

High-throughput

0.618

High

960415

KI13B
Kinesin-like protein KIF13B

1

4

High-throughput

0.618

High

960424

ZBT21
Zinc finger and BTB domain-containing protein 21

1

3

High-throughput

0.618

High

960425

PPM1H
Protein phosphatase 1H

1

5

High-throughput

0.618

High

960426

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

1

High-throughput

0.618

High

960428

GAB2
GRB2-associated-binding protein 2

1

4

High-throughput

0.618

High

646800

1433T
14-3-3 protein theta

2

20

Small-scale

0.614

High

960379

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

2

6

High-throughput

0.611

High

960401

SNX27
Sorting nexin-27

2

3

High-throughput

0.611

High

960409

MCMBP
Mini-chromosome maintenance complex-binding protein

2

0

High-throughput

0.602

High

277495

CCNK
Cyclin-K

1

20

Small-scale

0.590

High

803488

BAG6
Large proline-rich protein BAG6

1

10

High-throughput

0.590

High

960362

CCNI
Cyclin-I

1

20

Small-scale

0.590

High

960374

SPDYA
Speedy protein A

1

17

Small-scale

0.590

High

960408

RTKN
Rhotekin

1

0

High-throughput

0.586

High

960419

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

0

High-throughput

0.586

High

960397

APBP2
Amyloid protein-binding protein 2

1

4

High-throughput

0.573

High

960380

AN34A
Ankyrin repeat domain-containing protein 34A

1

1

High-throughput

0.553

High

537872

KPYM
Pyruvate kinase PKM

1

3

High-throughput

0.536

High

703521

CP2CI
Cytochrome P450 2C18

1

2

High-throughput

0.536

High

722598

T2FA
General transcription factor IIF subunit 1

1

2

High-throughput

0.536

High

915164

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

10

High-throughput

0.536

High

927798

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

6

High-throughput

0.536

High

960412

I20L2
Interferon-stimulated 20 kDa exonuclease-like 2

1

1

High-throughput

0.536

High

960430

SGT1
Protein SGT1 homolog

1

3

High-throughput

0.536

High

960368

SC23A
Protein transport protein Sec23A

1

5

Small-scale

0.529

High

394546

A4
Amyloid-beta precursor protein

1

7

High-throughput

0.501

High

960391

PJA1
E3 ubiquitin-protein ligase Praja-1

1

1

Small-scale

0.501

High

960414

RC3H2
Roquin-2

1

5

High-throughput

0.489

High

893789

S10AA
Protein S100-A10

1

13

Small-scale

0.481

High

960395

ATRIP
ATR-interacting protein

1

1

High-throughput

0.481

High

162632

XPO1
Exportin-1

1

4

High-throughput

0.479

High

196431

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

3

High-throughput

0.479

High

237198

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

2

High-throughput

0.479

High

253340

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

4

High-throughput

0.479

High

264293

GGYF1
GRB10-interacting GYF protein 1

1

3

High-throughput

0.479

High

303170

HEXI1
Protein HEXIM1

1

8

High-throughput

0.479

High

359858

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

9

High-throughput

0.479

High

506969

LAMP1
Lysosome-associated membrane glycoprotein 1

1

2

High-throughput

0.479

High

598462

NF1
Neurofibromin

1

4

High-throughput

0.479

High

650973

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

669983

MARCS
Myristoylated alanine-rich C-kinase substrate

1

7

High-throughput

0.479

High

683965

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

880683

HDAC4
Histone deacetylase 4

1

5

High-throughput

0.479

High

912854

ARF6
ADP-ribosylation factor 6

1

4

High-throughput

0.479

High

960359

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

4

High-throughput

0.479

High

960361

CUL3
Cullin-3

1

5

High-throughput

0.479

High

960370

ZYX
Zyxin

1

3

High-throughput

0.479

High

960377

SPD2A
SH3 and PX domain-containing protein 2A

1

1

High-throughput

0.479

High

960378

DEN4C
DENN domain-containing protein 4C

1

1

High-throughput

0.479

High

960381

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.479

High

960392

F110B
Protein FAM110B

1

1

High-throughput

0.479

High

960393

DEN1A
DENN domain-containing protein 1A

1

2

High-throughput

0.479

High

960399

SH3K1
SH3 domain-containing kinase-binding protein 1

1

2

High-throughput

0.479

High

960400

EDC3
Enhancer of mRNA-decapping protein 3

1

1

High-throughput

0.479

High

960402

SCLT1
Sodium channel and clathrin linker 1

1

20

High-throughput

0.479

High

960403

RAB3I
Rab-3A-interacting protein

1

1

High-throughput

0.479

High

960404

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

5

High-throughput

0.479

High

960406

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

1

High-throughput

0.479

High

960407

F110A
Protein FAM110A

1

1

High-throughput

0.479

High

960420

CING
Cingulin

1

13

High-throughput

0.479

High

960421

LIMA1
LIM domain and actin-binding protein 1

1

4

High-throughput

0.479

High

960422

NGAP
Ras GTPase-activating protein nGAP

1

5

High-throughput

0.479

High

960423

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

5

High-throughput

0.479

High

960429

LAMP3
Lysosome-associated membrane glycoprotein 3

1

2

High-throughput

0.479

High

960431

CBY1
Protein chibby homolog 1

1

1

High-throughput

0.479

High

960432

KCTD3
BTB/POZ domain-containing protein KCTD3

1

4

High-throughput

0.479

High

316245

NADK
NAD kinase

1

0

High-throughput

0.458

High

960417

FA53C
Protein FAM53C

1

0

High-throughput

0.458

High

960418

SH3B4
SH3 domain-binding protein 4

1

0

High-throughput

0.458

High

69233

MI4GD
MIF4G domain-containing protein

1

3

Small-scale

0.457

High

297854

SC24D
Protein transport protein Sec24D

1

7

Small-scale

0.457

High

960371

UAP1
UDP-N-acetylhexosamine pyrophosphorylase

1

4

Small-scale

0.457

High

960356

PTPS
6-pyruvoyl tetrahydrobiopterin synthase

1

0

Small-scale

0.438

High

720243

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

960372

TBC25
TBC1 domain family member 25

1

3

High-throughput

0.437

High

960384

SYDE1
Rho GTPase-activating protein SYDE1

1

4

High-throughput

0.437

High

960416

FBX8
F-box only protein 8

1

1

Small-scale

0.417

High

960385

NUP54
Nucleoporin p54

2

0

High-throughput

0.328

High

960394

DEP1B
DEP domain-containing protein 1B

1

0

High-throughput

0.249

Low

960398

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.249

Low

960383

CF20D
Protein CFAP20DC

1

0

Small-scale

0.238

Low

960389

TMM99
Uncharacterized protein KRT10-AS1

1

0

Small-scale

0.238

Low


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Last updated: 15 Jul 2024