HitPredict

Interactor 1: BCR (P11274)
Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26)
Gene: BCR

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.987

Property	Details
Experiments	10887132, 15143164, 32203420, 9178913, 7529874, 14725908, 28514442, 8112292, 33961781, 19380743, 21706016, 11726515, 9174058, 8955135, 8995379
Identification Methods	affinity chromatography technology, far western blotting, two hybrid, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	C2~SH2, RhoGEF~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0030036 - actin cytoskeleton organization GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1271 Hs			1 217
+	Hs
		506586 BCR_HUMAN (1-1271): 0: 1005: 100.00		GRAP_HUMAN (1-213): 2.32e-66: 205: 56.74
+	Mm
		1141138 BCR_MOUSE (1-1271): 0: 941: 93.79		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Hs
		337325 BCR_HUMAN (1-1271): 0: 1005: 100.00		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		442768 BCR_HUMAN (1-1271): 0: 1005: 100.00		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Hs
		506538 BCR_HUMAN (1-1271): 0: 1005: 100.00		FRK_HUMAN (150-212): 6.98e-11: 62.7: 27.78
+	Hs
		275167 BCR_HUMAN (1-1271): 0: 1005: 100.00		GRAP2_HUMAN (3-55): 1.58e-10: 61.3: 39.62
+	Hs
		337453 ABR_HUMAN (419-1271): 0: 567: 66.47		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		924658 FGD6_HUMAN (93-969): 1.47e-86: 311: 14.15		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924525 ARHG5_HUMAN (95-862): 8.55e-82: 297: 14.49		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Mm
		654982 VAV_MOUSE (393-1106): 2.14e-78: 279: 11.78		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Hs
		924777 Q96D37_HUMAN (393-1092): 1.17e-77: 275: 12.29		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		411673 FGD1_HUMAN (162-971): 1.22e-77: 279: 13.57		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		411580 VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		337333 VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		1078876 PREX1_HUMAN (447-1058): 2.05e-83: 302: 15.70		ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00
+	Hs
		1078919 ITSN1_HUMAN (74-927): 1.53e-78: 287: 13.61		ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67
+	Hs
		433726 ARHG5_HUMAN (95-862): 8.55e-82: 297: 14.49		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		1078828 ITSN1_HUMAN (74-927): 1.53e-78: 287: 13.61		ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00
+	Hs
		433781 ITSN1_HUMAN (74-927): 1.53e-78: 287: 13.61		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		411981 VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58