HitPredict

Interactor 1: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: FGF5 (P12034)
Fibroblast growth factor 5 (FGF-5) (Heparin-binding growth factor 5) (HBGF-5) (Smag-82)
Gene: FGF5

Species: Homo sapiens

Source: dip

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.727

Property	Details
Experiments	18199118, 8386828
Identification Methods	unspecified method, biochemical
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	FGF~I-set
Common GO terms	GO:0005576 - extracellular region GO:0008284 - positive regulation of cell population proliferation GO:0008543 - fibroblast growth factor receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Hs			1 268
+	Hs
		507874 FGFR1_HUMAN (1-822): 0: 861: 100.00		FGF9_HUMAN (26-229): 3.84e-76: 232: 36.36
+	Mm
		555263 FGFR1_MOUSE (1-822): 0: 860: 98.42		FGF9_MOUSE (26-229): 2.86e-76: 232: 36.36
+	Hs
		441802 FGFR1_HUMAN (1-822): 0: 861: 100.00		FGF4_HUMAN (30-219): 4.84e-64: 201: 37.37
+	Hs
		507813 FGFR1_HUMAN (1-822): 0: 861: 100.00		FGF3_HUMAN (63-246): 1.23e-60: 193: 34.54
+	Hs
		499375 FGFR1_HUMAN (1-822): 0: 861: 100.00		FGF6_HUMAN (48-219): 8.71e-61: 192: 37.22
+	Hs
		181657 FGFR1_HUMAN (1-822): 0: 861: 100.00		FGF10_HUMAN (65-222): 1.95e-60: 191: 37.11
+	Hs
		447013 FGFR1_HUMAN (1-822): 0: 861: 100.00		FGF2_HUMAN (46-222): 2.38e-56: 184: 34.27
+	Mm
		555272 FGFR1_MOUSE (1-822): 0: 860: 98.42		FGF23_MOUSE (62-254): 9.27e-56: 181: 28.71
+	Hs
		508186 FGFR1_HUMAN (1-822): 0: 861: 100.00		FGF23_HUMAN (60-254): 2.15e-53: 175: 25.12
+	Mm
		549545 FGFR1_MOUSE (1-822): 0: 860: 98.42		FGF2_MOUSE (54-222): 2.05e-54: 174: 35.88
+	Hs
		399128 FGFR1_HUMAN (1-822): 0: 861: 100.00		FGF1_HUMAN (54-223): 1.34e-51: 167: 30.99
+	Mm
		555273 FGFR1_MOUSE (1-822): 0: 860: 98.42		FGF21_MOUSE (74-252): 2.09e-48: 161: 25.64
+	Hs
		320638 FGFR1_HUMAN (1-822): 0: 861: 100.00		FGF19_HUMAN (58-231): 1.9e-45: 153: 26.26
+	Hs
		507927 FGFR1_HUMAN (1-822): 0: 861: 100.00		FGF8_HUMAN (48-229): 6.22e-42: 145: 26.70
+	Hs
		441808 FGFR2_HUMAN (1-821): 0: 803: 71.21		FGF4_HUMAN (30-219): 4.84e-64: 201: 37.37
+	Hs
		225915 FGFR1_HUMAN (1-822): 0: 861: 100.00		FGF17_HUMAN (72-225): 5.92e-38: 134: 26.42
+	Hs
		181659 FGFR2_HUMAN (1-821): 0: 803: 71.21		FGF10_HUMAN (65-222): 1.95e-60: 191: 37.11
+	Hs
		447019 FGFR2_HUMAN (1-821): 0: 803: 71.21		FGF2_HUMAN (46-222): 2.38e-56: 184: 34.27
+	Hs
		399132 FGFR2_HUMAN (1-821): 0: 803: 71.21		FGF1_HUMAN (54-223): 1.34e-51: 167: 30.99
+	Hs
		225918 FGFR2_HUMAN (1-821): 0: 803: 71.21		FGF17_HUMAN (72-225): 5.92e-38: 134: 26.42