Protein: KSS1
Mitogen-activated protein kinase KSS1 (MAP kinase KSS1) (EC 2.7.11.24) (Kinase suppressor of SST2)

Gene: KSS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 175
UniProt ID: P14681

Gene Ontology (top 5):
GO:0000749 - response to pheromone triggering conjugation with cellular fusion
GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion
GO:0001402 - signal transduction involved in filamentous growth
GO:0001403 - invasive growth in response to glucose limitation
GO:0004672 - protein kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

448848

STE7
Serine/threonine-protein kinase STE7

16

20

Small-scale

0.987

High

574637

STE11
Serine/threonine-protein kinase STE11

5

20

Small-scale

0.920

High

574661

STE5
Protein STE5

4

2

Small-scale

0.883

High

574673

MSG5
Tyrosine-protein phosphatase MSG5

4

20

Small-scale

0.881

High

574659

BEM3
GTPase-activating protein BEM3

3

6

Small-scale

0.857

High

392135

HSP82
ATP-dependent molecular chaperone HSP82

2

20

High-throughput

0.799

High

564635

STE12
Protein STE12

9

3

Small-scale

0.756

High

574732

DIG1
Down-regulator of invasive growth 1

8

2

Small-scale

0.755

High

574733

DIG2
Down-regulator of invasive growth 2

7

1

Small-scale

0.751

High

574621

KSS1
Mitogen-activated protein kinase KSS1

2

16

Small-scale

0.744

High

574626

FUS3
Mitogen-activated protein kinase FUS3

2

17

Small-scale

0.743

High

574664

PP2C1
Protein phosphatase 2C homolog 1

1

14

High-throughput

0.724

High

574667

KDX1
Serine/threonine-protein kinase KDX1

1

17

High-throughput

0.691

High

574759

ARP7
Actin-related protein 7

1

9

High-throughput

0.691

High

574697

CAF16
CCR4-associated factor 16

1

0

High-throughput

0.687

High

574630

TEC1
Ty transcription activator TEC1

3

2

Small-scale

0.667

High

574730

CDC14
Tyrosine-protein phosphatase CDC14

1

20

High-throughput

0.665

High

550564

SST2
Protein SST2

1

2

Small-scale

0.656

High

574708

DOHH
Deoxyhypusine hydroxylase

1

1

High-throughput

0.647

High

574727

APJ1
J domain-containing protein APJ1

1

10

High-throughput

0.647

High

574644

MAS5
Mitochondrial protein import protein MAS5

1

10

High-throughput

0.646

High

574654

RPN2
26S proteasome regulatory subunit RPN2

1

4

High-throughput

0.646

High

574728

ACT
Actin

1

8

High-throughput

0.646

High

574662

BCK2
Protein BCK2

2

1

High-throughput

0.628

High

574742

RGC1
Regulator of the glycerol channel 1

2

5

High-throughput

0.628

High

574648

MIG1
Regulatory protein MIG1

1

2

Small-scale

0.621

High

574717

MIG2
Regulatory protein MIG2

1

10

Small-scale

0.621

High

574642

NAP1
Nucleosome assembly protein

2

3

High-throughput

0.619

High

574702

SYEC
Glutamate--tRNA ligase, cytoplasmic

2

4

High-throughput

0.619

High

438180

CDC37
Hsp90 co-chaperone Cdc37

1

9

Small-scale

0.618

High

509368

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

7

High-throughput

0.618

High

574725

BNI4
Protein BNI4

2

1

Small-scale

0.586

High

574740

RRP5
rRNA biogenesis protein RRP5

1

1

High-throughput

0.579

High

574686

TSC11
Target of rapamycin complex 2 subunit TSC11

2

2

High-throughput

0.574

High

416852

CDC25
Cell division control protein 25

1

3

Small-scale

0.561

High

574641

PTP1
Tyrosine-protein phosphatase 1

1

15

High-throughput

0.561

High

574656

TCA17
TRAPP-associated protein TCA17

1

1

High-throughput

0.541

High

574623

CATA
Peroxisomal catalase A

1

0

High-throughput

0.537

High

574646

POF1
Nicotinamide mononucleotide adenylyltransferase

1

0

High-throughput

0.537

High

574720

SNU71
U1 small nuclear ribonucleoprotein component SNU71

1

0

High-throughput

0.537

High

574748

NBA1
Protein NBA1

1

0

High-throughput

0.537

High

574752

NSL1
Kinetochore-associated protein NSL1

1

0

High-throughput

0.537

High

420874

PMA1
Plasma membrane ATPase 1

1

6

High-throughput

0.536

High

538316

PYC1
Pyruvate carboxylase 1

1

5

High-throughput

0.536

High

574635

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

4

High-throughput

0.536

High

574655

CBS
Cystathionine beta-synthase

1

5

High-throughput

0.536

High

574668

LONM
Lon protease homolog, mitochondrial

1

8

High-throughput

0.536

High

574674

YHJ3
Uncharacterized protein YHR033W

1

1

High-throughput

0.536

High

574677

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.536

High

574682

TCPB
T-complex protein 1 subunit beta

1

16

High-throughput

0.536

High

574692

MKT1
Post-transcriptional regulator MKT1

1

1

High-throughput

0.536

High

574713

ASK10
Activator of SKN7 protein 10

1

5

High-throughput

0.536

High

574715

SYEM
Glutamate--tRNA ligase, mitochondrial

1

4

High-throughput

0.536

High

574729

SEN1
Helicase SEN1

1

1

High-throughput

0.536

High

574734

HAS1
ATP-dependent RNA helicase HAS1

1

7

High-throughput

0.536

High

574736

RUVB1
RuvB-like protein 1

1

7

High-throughput

0.536

High

574749

AVO1
Target of rapamycin complex 2 subunit AVO1

1

2

High-throughput

0.536

High

574709

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.513

High

574735

YD239
Uncharacterized protein YDR239C

1

0

High-throughput

0.513

High

574755

RNH2C
Ribonuclease H2 subunit C

1

0

High-throughput

0.513

High

574681

MPT5
Suppressor protein MPT5

1

1

Small-scale

0.508

High

438246

NOT3
General negative regulator of transcription subunit 3

1

1

High-throughput

0.501

High

514924

YA11A
Transposon Ty1-A Gag polyprotein

1

12

High-throughput

0.501

High

561406

TBP
TATA-box-binding protein

1

1

High-throughput

0.501

High

574638

SPT6
Transcription elongation factor SPT6

1

2

High-throughput

0.501

High

574650

MCM2
DNA replication licensing factor MCM2

1

12

High-throughput

0.501

High

574651

EF1G1
Elongation factor 1-gamma 1

1

7

High-throughput

0.501

High

574653

GLNA
Glutamine synthetase

1

1

High-throughput

0.501

High

574657

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

5

High-throughput

0.501

High

574660

DRS1
ATP-dependent RNA helicase DRS1

1

7

High-throughput

0.501

High

574663

YBF5
Deoxyribonuclease Tat-D

1

1

High-throughput

0.501

High

574669

ADCS
Aminodeoxychorismate synthase

1

7

High-throughput

0.501

High

574675

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

2

High-throughput

0.501

High

574676

OSH7
Oxysterol-binding protein homolog 7

1

1

High-throughput

0.501

High

574685

UBP9
Ubiquitin carboxyl-terminal hydrolase 9

1

3

High-throughput

0.501

High

574689

ASG1
Activator of stress genes 1

1

2

High-throughput

0.501

High

574698

BUD27
Bud site selection protein 27

1

1

High-throughput

0.501

High

574700

IRC5
Uncharacterized ATP-dependent helicase IRC5

1

3

High-throughput

0.501

High

574703

ARC1
tRNA-aminoacylation cofactor ARC1

1

2

High-throughput

0.501

High

574710

ADK
Adenosine kinase

1

7

High-throughput

0.501

High

574714

PFD3
Prefoldin subunit 3

1

1

High-throughput

0.501

High

574726

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

6

High-throughput

0.501

High

574746

BDF2
Bromodomain-containing factor 2

1

13

High-throughput

0.501

High

574751

SAS10
Something about silencing protein 10

1

1

High-throughput

0.501

High

574758

YD21A
Transposon Ty2-DR1 Gag polyprotein

1

10

High-throughput

0.501

High

574761

YN12A
Transposon Ty1-NL2 Gag polyprotein

1

11

High-throughput

0.501

High

574762

NOT5
General negative regulator of transcription subunit 5

1

1

High-throughput

0.501

High

366906

ATPB
ATP synthase subunit beta, mitochondrial

1

11

High-throughput

0.500

High

386548

TBB
Tubulin beta chain

1

10

High-throughput

0.500

High

394178

EF1A
Elongation factor 1-alpha

1

7

High-throughput

0.500

High

408278

GAL1
Galactokinase

1

1

High-throughput

0.500

High

416357

HXKA
Hexokinase-1

1

3

High-throughput

0.500

High

452799

ATPA
ATP synthase subunit alpha, mitochondrial

1

11

High-throughput

0.500

High

453395

PYR1
Multifunctional protein URA2

1

9

High-throughput

0.500

High

486004

TBA1
Tubulin alpha-1 chain

1

10

High-throughput

0.500

High

486394

TBA3
Tubulin alpha-3 chain

1

10

High-throughput

0.500

High

531226

METK1
S-adenosylmethionine synthase 1

1

5

High-throughput

0.500

High

574624

VATB
V-type proton ATPase subunit B

1

11

High-throughput

0.500

High

574625

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

12

High-throughput

0.500

High

574632

METK2
S-adenosylmethionine synthase 2

1

5

High-throughput

0.500

High

574634

HSP60
Heat shock protein 60, mitochondrial

1

10

High-throughput

0.500

High

574645

SRO9
RNA-binding protein SRO9

1

3

High-throughput

0.500

High

574647

CDC48
Cell division control protein 48

1

5

High-throughput

0.500

High

574658

UGPA1
UTP--glucose-1-phosphate uridylyltransferase

1

1

High-throughput

0.500

High

574683

TCPD
T-complex protein 1 subunit delta

1

13

High-throughput

0.500

High

574695

TCPH
T-complex protein 1 subunit eta

1

13

High-throughput

0.500

High

574747

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

1

High-throughput

0.500

High

574754

HSP42
Heat shock protein 42

1

6

High-throughput

0.500

High

574760

RUVB2
RuvB-like protein 2

1

7

High-throughput

0.500

High

574622

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

1

High-throughput

0.489

High

574643

PHO84
Inorganic phosphate transporter PHO84

1

6

High-throughput

0.489

High

574679

HXT6
High-affinity hexose transporter HXT6

1

3

High-throughput

0.489

High

574757

RPN6
26S proteasome regulatory subunit RPN6

1

2

High-throughput

0.489

High

574741

CYK2
Cytokinesis protein 2

1

3

High-throughput

0.481

High

574627

SEC2
Rab guanine nucleotide exchange factor SEC2

1

0

High-throughput

0.480

High

574652

MLS1
Malate synthase 1

1

0

High-throughput

0.480

High

574666

MRP8
Uncharacterized protein MRP8

1

0

High-throughput

0.480

High

574670

NCL1
Multisite-specific tRNA:(cytosine-C(5))-methyltransferase

1

0

High-throughput

0.480

High

574672

HSM3
DNA mismatch repair protein HSM3

1

0

High-throughput

0.480

High

574691

ACA2
ATF/CREB activator 2

1

0

High-throughput

0.480

High

574705

SIP4
Protein SIP4

1

0

High-throughput

0.480

High

574707

ITPA
Inosine triphosphate pyrophosphatase

1

0

High-throughput

0.480

High

574716

RIR4
Ribonucleoside-diphosphate reductase small chain 2

1

0

High-throughput

0.480

High

574719

DUO1
DASH complex subunit DUO1

1

0

High-throughput

0.480

High

574723

REXO1
RNA exonuclease 1

1

0

High-throughput

0.480

High

574724

CAF40
Protein CAF40

1

0

High-throughput

0.480

High

574731

RNT1
Ribonuclease 3

1

0

High-throughput

0.480

High

574739

GSF2
Glucose-signaling factor 2

1

0

High-throughput

0.480

High

574756

HIF1
HAT1-interacting factor 1

1

0

High-throughput

0.480

High

574764

TAD3
tRNA-specific adenosine deaminase subunit TAD3

1

0

High-throughput

0.480

High

533152

GPA2
Guanine nucleotide-binding protein alpha-2 subunit

1

2

Small-scale

0.479

High

574649

TF2B
Transcription initiation factor IIB

1

9

High-throughput

0.479

High

574694

MPG1
Mannose-1-phosphate guanyltransferase

1

2

High-throughput

0.479

High

574665

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

574680

GDS1
GTPase-GDP dissociation stimulator BEM4

1

0

Small-scale

0.458

High

574706

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.458

High

574628

PDI
Protein disulfide-isomerase

1

3

High-throughput

0.457

High

574640

YSP3
Subtilisin-like protease 3

1

1

High-throughput

0.457

High

574678

GGC1
Mitochondrial GTP/GDP carrier protein 1

1

15

High-throughput

0.457

High

574688

VPS27
Vacuolar protein sorting-associated protein 27

1

3

High-throughput

0.457

High

574690

MAM33
Mitochondrial acidic protein MAM33

1

2

High-throughput

0.457

High

574699

HXT10
Hexose transporter HXT10

1

4

High-throughput

0.457

High

574704

DLD2
D-2-hydroxyglutarate--pyruvate transhydrogenase DLD2

1

1

High-throughput

0.457

High

574722

RL26B
Large ribosomal subunit protein uL24B

1

2

High-throughput

0.457

High

574737

YHM2
Citrate/oxoglutarate carrier protein

1

16

High-throughput

0.457

High

574738

ARA2
D-arabinose 1-dehydrogenase

1

2

High-throughput

0.457

High

574750

DGAT2
Diacylglycerol O-acyltransferase 1

1

3

High-throughput

0.457

High

405009

LEU3
3-isopropylmalate dehydrogenase

1

5

High-throughput

0.457

High

554868

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

2

High-throughput

0.457

High

554989

G6PI
Glucose-6-phosphate isomerase

1

3

High-throughput

0.457

High

574629

ADT2
ADP,ATP carrier protein 2

1

11

High-throughput

0.457

High

574631

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

2

High-throughput

0.457

High

574639

MPCP
Mitochondrial phosphate carrier protein

1

13

High-throughput

0.457

High

574701

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

1

3

High-throughput

0.457

High

510142

HSP77
Import motor subunit, mitochondrial

1

18

High-throughput

0.445

High

574687

SSB2
Ribosome-associated molecular chaperone SSB2

1

18

High-throughput

0.445

High

423580

ARGR2
Arginine metabolism regulation protein II

1

0

High-throughput

0.438

High

574633

ACON
Aconitate hydratase, mitochondrial

1

1

High-throughput

0.437

High

548255

FUS1
Nuclear fusion protein FUS1

1

2

Small-scale

0.417

High

574693

FET4
Low-affinity Fe(2+) transport protein

1

0

High-throughput

0.279

Low

574636

AIM17
Probable oxidoreductase AIM17

1

0

High-throughput

0.261

Low

574671

TOS1
Probable circularly permuted 1,3-beta-glucanase TOS1

1

0

High-throughput

0.261

Low

574684

HPH2
Protein HPH2

1

0

High-throughput

0.261

Low

574696

EMP47
Protein EMP47

1

0

High-throughput

0.261

Low

574711

ABM1
Aberrant microtubules protein 1

1

0

High-throughput

0.261

Low

574712

YJ9J
Uncharacterized protein YJR142W

1

0

High-throughput

0.261

Low

574718

MRM2
rRNA methyltransferase 2, mitochondrial

1

0

High-throughput

0.261

Low

574721

YG1A
Uncharacterized membrane protein YGR016W

1

0

High-throughput

0.261

Low

574743

PEX30
Peroxisomal membrane protein PEX30

1

0

High-throughput

0.261

Low

574744

CDA1
Chitin deacetylase 1

1

0

High-throughput

0.261

Low

574745

NVJ2
Nucleus-vacuole junction protein 2

1

0

High-throughput

0.261

Low

574753

SSF2
Ribosome biogenesis protein SSF2

1

0

High-throughput

0.261

Low

574763

VCX1
Vacuolar calcium ion transporter

1

0

High-throughput

0.261

Low

484709

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.261

Low


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Last updated: 11Aug2025