HitPredict

Interactor 1: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.884

Property	Details
Experiments	15117958, 8321198, 35384245, 18412956
Identification Methods	two hybrid, pull down, proximity labelling technology, coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Hs			1 724
+	Hs
		601463 FGFR2_HUMAN (1-821): 0: 803: 71.21		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		129184 FGFR1_HUMAN (1-822): 0: 861: 100.00		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		609182 FGFR3_HUMAN (6-821): 0: 730: 61.22		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		129199 FGFR2_HUMAN (1-821): 0: 803: 71.21		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		607886 FGFR4_HUMAN (29-808): 0: 664: 55.60		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		655220 EPHA3_HUMAN (3-775): 0: 643: 19.03		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		655222 EPHB2_HUMAN (4-819): 0: 640: 18.07		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		655284 EPHA5_HUMAN (3-791): 0: 639: 19.15		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		129201 FGFR4_HUMAN (29-808): 0: 664: 55.60		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		129209 EPHA3_HUMAN (3-775): 0: 643: 19.03		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		129211 EPHB2_HUMAN (4-819): 0: 640: 18.07		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		129252 EPHA5_HUMAN (3-791): 0: 639: 19.15		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		129297 EPHA7_HUMAN (3-783): 0: 629: 19.40		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		253307 FGFR1_HUMAN (1-822): 0: 861: 100.00		SRGP2_HUMAN (118-668): 3.41e-54: 203: 13.78
+	Hs
		608065 FGFR4_HUMAN (29-808): 0: 664: 55.60		P55G_HUMAN (271-723): 1.4e-104: 329: 72.31
+	Hs
		433229 FGFR1_HUMAN (1-822): 0: 861: 100.00		YES_HUMAN (568-724): 2.15e-31: 131: 20.61
+	Hs
		872468 EPHA5_HUMAN (3-791): 0: 639: 19.15		P55G_HUMAN (271-723): 1.4e-104: 329: 72.31
+	Hs
		64660 EPHB2_HUMAN (4-819): 0: 640: 18.07		RHG32_HUMAN (14-613): 1.13e-61: 227: 13.99
+	Hs
		253317 EPHB2_HUMAN (4-819): 0: 640: 18.07		SRGP2_HUMAN (118-668): 3.41e-54: 203: 13.78
+	Hs
		433265 EPHB2_HUMAN (4-819): 0: 640: 18.07		YES_HUMAN (568-724): 2.15e-31: 131: 20.61