HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: ROA3 (P51991)
Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3)
Gene: HNRNPA3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	35271311, 15848144
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 765 Hs			1 378
+	Hs
		161947 TOP1_HUMAN (1-765): 0: 932: 100.00		HNRDL_HUMAN (20-303): 9.32e-70: 226: 32.30
+	Hs
		508516 TOP1_HUMAN (1-765): 0: 932: 100.00		HNRPD_HUMAN (8-299): 1.73e-54: 184: 34.59
+	Hs
		508679 TOP1_HUMAN (1-765): 0: 932: 100.00		ROAA_HUMAN (12-208): 7.23e-36: 135: 38.38
+	Hs
		508336 TOP1_HUMAN (1-765): 0: 932: 100.00		ROA2_HUMAN (8-126): 3.48e-26: 109: 29.27
+	Hs
		453106 TOP1_HUMAN (1-765): 0: 932: 100.00		ROA1_HUMAN (8-116): 5.62e-19: 89.4: 29.20
+	Hs
		508496 TOP1_HUMAN (1-765): 0: 932: 100.00		ROA0_HUMAN (17-115): 5.36e-10: 62: 34.34
+	Sc
		376565 TOP1_YEAST (600-765): 7.36e-26: 115: 34.88		PABP_YEAST (6-107): 6.88e-17: 84: 25.24
+	Hs
		1026091 THOC2_HUMAN (7-198): 3.62e-09: 62.4: 16.42		ROA0_HUMAN (17-115): 5.36e-10: 62: 34.34