HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: DHX9 (Q08211)
ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A)
Gene: DHX9

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.67 0.60 0.635

The method score is based on:

Property Details
Experiments 35271311, 15848144
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, pull down, anti bait coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003677 - DNA binding
GO:0003690 - double-stranded DNA binding
GO:0003697 - single-stranded DNA binding
GO:0003723 - RNA binding
and 5 others

more...
Homologous interactions 4

Homologous interactions

Color coding for hit scores

1 765
Hs

1 1270
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024