Interactor 1: TOP2A (P11388)
DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme)
Gene: TOP2A

Interactor 2: TOP2A (P11388)
DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme)
Gene: TOP2A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.33 1.00 0.575

The method score is based on:

Property Details
Experiments 9972548
Identification Methods x-ray crystallography
Interaction Type association

The annotation score is based on:

Property Details
Interacting Pfam domains DNA_gyraseB~DNA_gyraseB, DNA_gyraseB~DNA_topoisoIV, DNA_gyraseB~HATPase_c, DNA_gyraseB~Toprim, DNA_topoisoIV~DNA_topoisoIV, DNA_topoisoIV~Toprim, DNA_topoisoIV~TOPRIM_C, HATPase_c~HATPase_c, Toprim~Toprim, TOPRIM_C~Toprim
Common GO terms GO:0000287 - magnesium ion binding
GO:0000712 - resolution of meiotic recombination intermediates
GO:0000775 - chromosome, centromeric region
GO:0000793 - condensed chromosome
GO:0000819 - sister chromatid segregation
and 33 others

more...

Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 1531
Hs

1 1531
+ Hs
+ Dm
+ Zm
+ Sc
+ Ec
+ Mp
+ At
+ Sp
+ Mp
+ Mp
+ Ec
+ Ec
+ Ec
+ Ec
+ Ec
+ Hp

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Last updated: 15 Jul 2024