HitPredict

Interactor 1: DA (P11420)
Protein daughterless
Gene: DA

Interactor 2: FER3 (Q9VGJ5)
Protein Fer3 (Basic helix-loop-helix protein N-twist) (Nephew of atonal 3) (Neuronal twist)
Gene: FER3

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	14605208
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0003700 - DNA-binding transcription factor activity GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0046982 - protein heterodimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 710 Dm			1 195
+	Dm
		80865 DA_DROME (1-710): 0: 908: 100.00		DIMM_DROME (28-187): 8.59e-26: 103: 21.12
+	Dm
		509356 DA_DROME (1-710): 0: 908: 100.00		MYOD_DROME (7-176): 1.08e-25: 102: 19.88
+	Dm
		509364 DA_DROME (1-710): 0: 908: 100.00		ATO_DROME (34-143): 4.51e-25: 100: 31.82
+	Dm
		509390 DA_DROME (1-710): 0: 908: 100.00		AMOS_DROME (6-145): 6.72e-26: 100: 31.69
+	Dm
		509380 DA_DROME (1-710): 0: 908: 100.00		Q9VL05_DROME (78-158): 2.34e-25: 98.5: 33.33
+	Dm
		496114 DA_DROME (1-710): 0: 908: 100.00		TWIST_DROME (76-145): 3.88e-18: 83.3: 42.86
+	Mm
		1142072 HTF4_MOUSE (219-662): 1.64e-142: 435: 35.32		HAND2_MOUSE (22-153): 4.82e-27: 103: 22.73
+	Mm
		1142451 HTF4_MOUSE (219-662): 1.64e-142: 435: 35.32		ASCL3_MOUSE (6-159): 1.68e-25: 98.9: 27.92
+	Hs
		551571 HTF4_HUMAN (219-662): 5.86e-134: 412: 35.33		TFE2_HUMAN (3-192): 1.45e-28: 113: 16.41
+	Hs
		1039378 HTF4_HUMAN (219-662): 5.86e-134: 412: 35.33		NDF1_HUMAN (1-193): 4.29e-29: 112: 22.48
+	Mm
		644476 HTF4_MOUSE (219-662): 1.64e-142: 435: 35.32		TWST1_MOUSE (78-149): 9.77e-20: 84.4: 41.67
+	Hs
		568226 HTF4_HUMAN (219-662): 5.86e-134: 412: 35.33		TAL1_HUMAN (13-155): 3.89e-27: 106: 28.28
+	Hs
		616615 HTF4_HUMAN (219-662): 5.86e-134: 412: 35.33		MYF6_HUMAN (29-188): 8.81e-27: 103: 21.08
+	Hs
		899129 HTF4_HUMAN (219-662): 5.86e-134: 412: 35.33		HAND2_HUMAN (22-153): 4.82e-27: 103: 22.73
+	Hs
		1018388 HTF4_HUMAN (219-662): 5.86e-134: 412: 35.33		TCF15_HUMAN (87-182): 2.22e-26: 101: 32.99
+	Hs
		1261463 HTF4_HUMAN (219-662): 5.86e-134: 412: 35.33		TWST2_HUMAN (63-150): 5.13e-26: 99.5: 32.96
+	Hs
		546105 HTF4_HUMAN (219-662): 5.86e-134: 412: 35.33		MYOG_HUMAN (2-195): 3.58e-25: 99.2: 24.24
+	Hs
		1083176 HTF4_HUMAN (219-662): 5.86e-134: 412: 35.33		TAL2_HUMAN (85-193): 4.25e-26: 98.1: 31.19
+	Hs
		210863 HTF4_HUMAN (219-662): 5.86e-134: 412: 35.33		TCF21_HUMAN (43-148): 3.11e-25: 98.1: 26.42
+	Hs
		1076858 HTF4_HUMAN (219-662): 5.86e-134: 412: 35.33		TWST1_HUMAN (78-149): 3.05e-19: 82.9: 41.67