HitPredict

Interactor 1: CDK1 (P11440)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Interactor 2: H12 (P15864)
Histone H1.2 (H1 VAR.1) (H1c)
Gene: H1-2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	11380680, 11641775
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0030261 - chromosome condensation
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 297 Mm			1 212
+	Rn
		413197 Q6P751_RAT (1-297): 7e-149: 420: 64.31		H1T_RAT (1-198): 4.13e-34: 122: 49.26
+	Hs
		559328 CDK2_HUMAN (1-297): 5.15e-149: 421: 64.65		H13_HUMAN (1-167): 1.8e-28: 108: 83.93
+	Hs
		414717 CDK1_HUMAN (1-297): 4.17e-143: 406: 96.97		H13_HUMAN (1-167): 1.8e-28: 108: 83.93
+	Rn
		88903 Q6P751_RAT (1-297): 7e-149: 420: 64.31		H11_RAT (1-120): 1.06e-22: 93.2: 66.39
+	Hs
		558990 CDK2_HUMAN (1-297): 5.15e-149: 421: 64.65		H15_HUMAN (1-115): 1.43e-20: 87.8: 80.51
+	Hs
		625377 CDK2_HUMAN (1-297): 5.15e-149: 421: 64.65		H11_HUMAN (38-197): 2.16e-18: 81.6: 60.00
+	Rn
		88899 CDK1_RAT (1-297): 7.05e-143: 405: 99.33		H11_RAT (1-120): 1.06e-22: 93.2: 66.39
+	Hs
		414716 CDK1_HUMAN (1-297): 4.17e-143: 406: 96.97		H15_HUMAN (1-115): 1.43e-20: 87.8: 80.51
+	Mm
		794656 CDK2_MOUSE (1-297): 3.4e-140: 400: 55.36		H15_MOUSE (1-198): 8.14e-22: 90.9: 60.77
+	Hs
		414874 CDK1_HUMAN (1-297): 4.17e-143: 406: 96.97		H11_HUMAN (38-197): 2.16e-18: 81.6: 60.00
+	Hs
		559654 CDK5_HUMAN (1-293): 3.39e-134: 383: 56.80		H12_HUMAN (1-173): 5.41e-26: 101: 90.17
+	Mm
		509472 CDK1_MOUSE (1-297): 5.4e-142: 403: 100.00		H11_MOUSE (1-121): 3.4e-17: 78.6: 65.85
+	Mm
		550489 CDK2_MOUSE (1-297): 3.4e-140: 400: 55.36		H12_MOUSE (1-115): 8.84e-18: 80.1: 100.00
+	Hs
		489003 CDK5_HUMAN (1-293): 3.39e-134: 383: 56.80		H14_HUMAN (1-115): 7.27e-24: 96.3: 88.70
+	Mm
		794643 CDK2_MOUSE (1-297): 3.4e-140: 400: 55.36		H11_MOUSE (1-121): 3.4e-17: 78.6: 65.85
+	Hs
		559065 CDK5_HUMAN (1-293): 3.39e-134: 383: 56.80		H15_HUMAN (1-115): 1.43e-20: 87.8: 80.51
+	Hs
		960270 CDK5_HUMAN (1-293): 3.39e-134: 383: 56.80		H11_HUMAN (38-197): 2.16e-18: 81.6: 60.00
+	Mm
		794639 CDK5_MOUSE (1-293): 5.14e-134: 383: 56.80		H11_MOUSE (1-121): 3.4e-17: 78.6: 65.85