Protein: NCOA6
Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein)

Gene: NCOA6
Organism: Homo sapiens
Interactions: 131
UniProt ID: Q14686

Gene Ontology (top 5):
GO:0003682 - chromatin binding
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005667 - transcription regulator complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

964950

WDR5
WD repeat-containing protein 5

11

15

Small-scale

0.760

High

1130606

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

12

10

Small-scale

0.759

High

1130565

RBBP5
Retinoblastoma-binding protein 5

10

20

Small-scale

0.758

High

625814

RXRA
Retinoic acid receptor RXR-alpha

6

20

Small-scale

0.738

High

1130572

PAXI1
PAX-interacting protein 1

6

20

Small-scale

0.735

High

396119

ESR1
Estrogen receptor

6

20

Small-scale

0.735

High

1130579

KMT2C
Histone-lysine N-methyltransferase 2C

6

20

Small-scale

0.734

High

194564

KDM6A
Lysine-specific demethylase 6A

6

14

Small-scale

0.730

High

404058

GCR
Glucocorticoid receptor

6

20

Small-scale

0.725

High

533344

THB
Thyroid hormone receptor beta

5

20

Small-scale

0.704

High

520581

RARA
Retinoic acid receptor alpha

4

20

Small-scale

0.694

High

1130608

KMT2B
Histone-lysine N-methyltransferase 2B

4

20

Small-scale

0.694

High

789496

PPARG
Peroxisome proliferator-activated receptor gamma

5

20

Small-scale

0.691

High

833940

HNF4A
Hepatocyte nuclear factor 4-alpha

4

20

Small-scale

0.688

High

533280

THA
Thyroid hormone receptor alpha

4

20

Small-scale

0.685

High

1130562

NCOA6
Nuclear receptor coactivator 6

3

17

Small-scale

0.680

High

1130587

CBP
CREB-binding protein

3

20

Small-scale

0.669

High

161467

KMT2D
Histone-lysine N-methyltransferase 2D

4

20

Small-scale

0.666

High

558134

XRCC6
X-ray repair cross-complementing protein 6

3

6

Small-scale

0.664

High

1130568

NCOA1
Nuclear receptor coactivator 1

3

10

Small-scale

0.658

High

1130597

PAGR1
PAXIP1-associated glutamate-rich protein 1

3

1

Small-scale

0.656

High

1130586

ESR2
Estrogen receptor beta

3

20

Small-scale

0.655

High

1130598

DPY30
Protein dpy-30 homolog

3

2

Small-scale

0.650

High

1130592

TGS1
Trimethylguanosine synthase

3

0

Small-scale

0.650

High

520044

ANDR
Androgen receptor

2

20

Small-scale

0.631

High

158695

UTY
Histone demethylase UTY

2

12

Small-scale

0.618

High

905405

HCFC1
Host cell factor 1

2

7

Small-scale

0.611

High

933941

NR1H2
Oxysterols receptor LXR-beta

2

20

Small-scale

0.609

High

952822

ACTB
Actin, cytoplasmic 1

2

13

Small-scale

0.602

High

886862

CEBPA
CCAAT/enhancer-binding protein alpha

2

18

Small-scale

0.601

High

413834

P53
Cellular tumor antigen p53

2

12

Small-scale

0.594

High

557306

SRC
Proto-oncogene tyrosine-protein kinase Src

2

8

Small-scale

0.594

High

442716

RB
Retinoblastoma-associated protein

1

4

Small-scale

0.586

High

583551

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

10

Small-scale

0.586

High

129081

MEN1
Menin

2

5

High-throughput

0.584

High

559356

XRCC5
X-ray repair cross-complementing protein 5

2

6

Small-scale

0.584

High

872329

SOX2
Transcription factor SOX-2

2

20

Small-scale

0.584

High

1029091

E2F1
Transcription factor E2F1

1

10

Small-scale

0.573

High

1088841

TP53B
TP53-binding protein 1

1

13

Small-scale

0.569

High

1008151

PRKDC
DNA-dependent protein kinase catalytic subunit

1

8

Small-scale

0.561

High

1026383

HSF1
Heat shock factor protein 1

1

3

Small-scale

0.561

High

1067333

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.561

High

1130573

H32
Histone H3.2

1

16

Small-scale

0.561

High

543506

VDR
Vitamin D3 receptor

1

20

Small-scale

0.552

High

219172

LTOR5
Ragulator complex protein LAMTOR5

1

0

Small-scale

0.549

High

347025

BAG2
BAG family molecular chaperone regulator 2

1

3

High-throughput

0.536

High

691008

1433T
14-3-3 protein theta

1

19

High-throughput

0.536

High

730589

1433S
14-3-3 protein sigma

1

19

High-throughput

0.536

High

966317

1433G
14-3-3 protein gamma

1

19

High-throughput

0.536

High

1049295

1433F
14-3-3 protein eta

1

19

High-throughput

0.536

High

1130574

TBA1A
Tubulin alpha-1A chain

1

7

Small-scale

0.536

High

1130589

DYL2
Dynein light chain 2, cytoplasmic

1

3

High-throughput

0.536

High

1130596

ASCL2
Achaete-scute homolog 2

1

9

Small-scale

0.536

High

282938

NR1I2
Nuclear receptor subfamily 1 group I member 2

1

20

Small-scale

0.527

High

1130590

RBM14
RNA-binding protein 14

1

2

Small-scale

0.527

High

1130602

TRXR2
Thioredoxin reductase 2, mitochondrial

1

2

Small-scale

0.527

High

1014515

SMAD3
Mothers against decapentaplegic homolog 3

1

8

High-throughput

0.508

High

1130569

SMAD2
Mothers against decapentaplegic homolog 2

1

8

High-throughput

0.508

High

1130600

ZN335
Zinc finger protein 335

1

0

Small-scale

0.504

High

370671

FOS
Protein c-Fos

1

16

Small-scale

0.501

High

429897

JUN
Transcription factor Jun

1

16

Small-scale

0.501

High

507978

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

High-throughput

0.501

High

549323

SRF
Serum response factor

1

2

Small-scale

0.501

High

626230

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

18

Small-scale

0.501

High

628779

TBP
TATA-box-binding protein

1

1

Small-scale

0.501

High

683241

TNR5
Tumor necrosis factor receptor superfamily member 5

1

2

Small-scale

0.501

High

1022715

XIAP
E3 ubiquitin-protein ligase XIAP

1

5

High-throughput

0.501

High

1045289

TF65
Transcription factor p65

1

14

Small-scale

0.501

High

1130567

MED1
Mediator of RNA polymerase II transcription subunit 1

1

17

Small-scale

0.501

High

1130577

ASCC1
Activating signal cointegrator 1 complex subunit 1

1

3

Small-scale

0.501

High

1130591

NR1H4
Bile acid receptor

1

20

Small-scale

0.501

High

1130612

GRIP1
Glutamate receptor-interacting protein 1

1

2

Small-scale

0.501

High

902778

RORG
Nuclear receptor ROR-gamma

1

20

High-throughput

0.481

High

1095497

NR1H3
Oxysterols receptor LXR-alpha

1

20

High-throughput

0.481

High

1130571

Q58EY0
RAR related orphan receptor B isoform 1

1

20

High-throughput

0.481

High

1130593

RANB9
Ran-binding protein 9

1

8

High-throughput

0.481

High

1130615

FHOD1
FH1/FH2 domain-containing protein 1

1

2

High-throughput

0.481

High

1130616

NCOR2
Nuclear receptor corepressor 2

1

17

Small-scale

0.481

High

913248

TF2AA
Transcription initiation factor IIA subunit 1

1

0

Small-scale

0.480

High

1130605

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

0

Small-scale

0.480

High

142995

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

181512

TBXT
T-box transcription factor T

1

14

High-throughput

0.479

High

224999

TLX3
T-cell leukemia homeobox protein 3

1

20

High-throughput

0.479

High

473988

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

487317

PARP1
Poly [ADP-ribose] polymerase 1

1

17

Small-scale

0.479

High

538396

EGR2
E3 SUMO-protein ligase EGR2

1

5

High-throughput

0.479

High

540864

ERG
Transcriptional regulator ERG

1

20

High-throughput

0.479

High

662424

GATA2
Endothelial transcription factor GATA-2

1

18

High-throughput

0.479

High

685195

PAX6
Paired box protein Pax-6

1

20

High-throughput

0.479

High

775084

FUS
RNA-binding protein FUS

1

14

High-throughput

0.479

High

862137

YAP1
Transcriptional coactivator YAP1

1

20

High-throughput

0.479

High

873087

SOX9
Transcription factor SOX-9

1

20

High-throughput

0.479

High

937751

FOXA1
Hepatocyte nuclear factor 3-alpha

1

15

High-throughput

0.479

High

938099

ANM2
Protein arginine N-methyltransferase 2

1

6

Small-scale

0.479

High

938445

PAX9
Paired box protein Pax-9

1

20

High-throughput

0.479

High

979658

H4
Histone H4

1

8

High-throughput

0.479

High

986429

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

High-throughput

0.479

High

1032965

EWS
RNA-binding protein EWS

1

18

High-throughput

0.479

High

1041523

KMT2A
Histone-lysine N-methyltransferase 2A

1

20

High-throughput

0.479

High

1087740

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1118705

KLF5
Krueppel-like factor 5

1

20

High-throughput

0.479

High

1130563

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

1130564

NUMA1
Nuclear mitotic apparatus protein 1

1

8

Small-scale

0.479

High

1130566

NCOA2
Nuclear receptor coactivator 2

1

13

Small-scale

0.479

High

1130570

SMAD1
Mothers against decapentaplegic homolog 1

1

8

Small-scale

0.479

High

1130575

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

10

High-throughput

0.479

High

1130576

SMC5
Structural maintenance of chromosomes protein 5

1

9

High-throughput

0.479

High

1130578

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

20

Small-scale

0.479

High

1130580

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

1

8

High-throughput

0.479

High

1130581

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.479

High

1130582

NUP35
Nucleoporin NUP35

1

3

High-throughput

0.479

High

1130583

MAFA
Transcription factor MafA

1

6

Small-scale

0.479

High

1130584

SP7
Transcription factor Sp7

1

15

High-throughput

0.479

High

1130585

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

2

High-throughput

0.479

High

1130588

FBXW7
F-box/WD repeat-containing protein 7

1

11

Small-scale

0.479

High

1130595

FEV
Protein FEV

1

20

High-throughput

0.479

High

1130599

WWTR1
WW domain-containing transcription regulator protein 1

1

20

High-throughput

0.479

High

1130601

SOX17
Transcription factor SOX-17

1

20

High-throughput

0.479

High

1130603

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

6

High-throughput

0.479

High

1130604

CXXC1
CXXC-type zinc finger protein 1

1

7

High-throughput

0.479

High

1130607

MED23
Mediator of RNA polymerase II transcription subunit 23

1

1

Small-scale

0.479

High

1130609

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

4

High-throughput

0.479

High

1130610

SET1B
Histone-lysine N-methyltransferase SETD1B

1

20

High-throughput

0.479

High

1130611

ASF1A
Histone chaperone ASF1A

1

8

High-throughput

0.479

High

1130613

MAFB
Transcription factor MafB

1

14

Small-scale

0.479

High

1130614

HCFC2
Host cell factor 2

1

6

High-throughput

0.479

High

447020

NPM
Nucleophosmin

1

1

Small-scale

0.457

High

533849

GHR
Growth hormone receptor

1

1

Small-scale

0.457

High

1063250

GOGA2
Golgin subfamily A member 2

1

8

High-throughput

0.437

High

1130594

CSF3R
Granulocyte colony-stimulating factor receptor

1

1

Small-scale

0.437

High


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Last updated: 11Aug2025