HitPredict

Interactor 1: CDK1 (P11440)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Interactor 2: H11 (P43275)
Histone H1.1 (H1 VAR.3) (Histone H1a) (H1a)
Gene: H1-1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.655

Property	Details
Experiments	8226784, 9247342, 7604037
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0030261 - chromosome condensation
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 297 Mm			1 213
+	Rn
		413197 Q6P751_RAT (1-297): 7e-149: 420: 64.31		H1T_RAT (1-201): 3.81e-36: 127: 49.25
+	Rn
		88903 Q6P751_RAT (1-297): 7e-149: 420: 64.31		H11_RAT (1-124): 5.9e-25: 99: 92.74
+	Hs
		559328 CDK2_HUMAN (1-297): 5.15e-149: 421: 64.65		H13_HUMAN (1-162): 1.31e-23: 95.5: 59.28
+	Hs
		558990 CDK2_HUMAN (1-297): 5.15e-149: 421: 64.65		H15_HUMAN (1-117): 1.41e-20: 87.8: 68.64
+	Rn
		88899 CDK1_RAT (1-297): 7.05e-143: 405: 99.33		H11_RAT (1-124): 5.9e-25: 99: 92.74
+	Hs
		414717 CDK1_HUMAN (1-297): 4.17e-143: 406: 96.97		H13_HUMAN (1-162): 1.31e-23: 95.5: 59.28
+	Hs
		625377 CDK2_HUMAN (1-297): 5.15e-149: 421: 64.65		H11_HUMAN (40-145): 6.4e-17: 77.8: 76.15
+	Hs
		414716 CDK1_HUMAN (1-297): 4.17e-143: 406: 96.97		H15_HUMAN (1-117): 1.41e-20: 87.8: 68.64
+	Mm
		794656 CDK2_MOUSE (1-297): 3.4e-140: 400: 55.36		H15_MOUSE (1-196): 9.52e-22: 90.9: 60.29
+	Mm
		794643 CDK2_MOUSE (1-297): 3.4e-140: 400: 55.36		H11_MOUSE (1-181): 1.43e-19: 84.7: 100.00
+	Hs
		414874 CDK1_HUMAN (1-297): 4.17e-143: 406: 96.97		H11_HUMAN (40-145): 6.4e-17: 77.8: 76.15
+	Mm
		509461 CDK1_MOUSE (1-297): 5.4e-142: 403: 100.00		H12_MOUSE (32-117): 4.78e-17: 78.2: 80.23
+	Mm
		550489 CDK2_MOUSE (1-297): 3.4e-140: 400: 55.36		H12_MOUSE (32-117): 4.78e-17: 78.2: 80.23
+	Hs
		489003 CDK5_HUMAN (1-293): 3.39e-134: 383: 56.80		H14_HUMAN (1-117): 1.45e-21: 90.1: 73.50
+	Hs
		559065 CDK5_HUMAN (1-293): 3.39e-134: 383: 56.80		H15_HUMAN (1-117): 1.41e-20: 87.8: 68.64
+	Hs
		559654 CDK5_HUMAN (1-293): 3.39e-134: 383: 56.80		H12_HUMAN (1-180): 1.1e-20: 87.8: 57.78
+	Mm
		794639 CDK5_MOUSE (1-293): 5.14e-134: 383: 56.80		H11_MOUSE (1-181): 1.43e-19: 84.7: 100.00
+	Hs
		960270 CDK5_HUMAN (1-293): 3.39e-134: 383: 56.80		H11_HUMAN (40-145): 6.4e-17: 77.8: 76.15