HitPredict

Interactor 1: VDR (P11473)
Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor) (Nuclear receptor subfamily 1 group I member 1)
Gene: VDR

Interactor 2: RXRA (P19793)
Retinoic acid receptor RXR-alpha (Nuclear receptor subfamily 2 group B member 1) (Retinoid X receptor alpha)
Gene: RXRA

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.992

The method score is based on:

Property Details
Experiments 20153625, 15888456, 26329759, 27728806, 9632709, 11514567, 15805579, 11075811, 10224118, 10037600, 17786964, 15604093, 15829977, 16750418, 17500032, 21478865, 16357103, 11149488, 10733574, 14726489 and 7 others

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Identification Methods two hybrid, pull down, affinity chromatography technology, x-ray crystallography, molecular sieving, x ray scattering, cosedimentation in solution, electrophoretic mobility supershift assay, electron microscopy
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Hormone_recep~Hormone_recep, Hormone_recep~zf-C4, zf-C4~zf-C4
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0004879 - nuclear receptor activity
and 11 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Last updated: 15 Jul 2024