HitPredict

Interactor 1: PYC (P11498)
Pyruvate carboxylase, mitochondrial (EC 6.4.1.1) (Pyruvic carboxylase) (PCB)
Gene: PC

Interactor 2: WDTC1 (Q8N5D0)
WD and tetratricopeptide repeats protein 1
Gene: WDTC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	37689310
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1178 Hs			1 677
+	Hs
		513584 PYC_HUMAN (1-1178): 0: 1462: 100.00		DCAF6_HUMAN (479-669): 8.52e-41: 161: 29.85
+	Hs
		1024047 ACACA_HUMAN (1-746): 1.06e-175: 573: 22.40		WDTC1_HUMAN (1-677): 4.96e-133: 408: 100.00
+	Hs
		136047 ACACB_HUMAN (1-742): 5.49e-175: 572: 23.27		WDTC1_HUMAN (1-677): 4.96e-133: 408: 100.00
+	Mm
		1131963 ACACA_MOUSE (1-746): 4.79e-176: 574: 22.52		WDTC1_MOUSE (1-677): 9.05e-131: 403: 93.66
+	Hs
		1024023 ACACA_HUMAN (1-746): 1.06e-175: 573: 22.40		DCAF6_HUMAN (479-669): 8.52e-41: 161: 29.85
+	Hs
		136024 ACACB_HUMAN (1-742): 5.49e-175: 572: 23.27		DCAF6_HUMAN (479-669): 8.52e-41: 161: 29.85
+	Hs
		135989 ACACB_HUMAN (1-742): 5.49e-175: 572: 23.27		LIS1_HUMAN (486-675): 1.15e-24: 109: 11.00
+	Hs
		136053 ACACB_HUMAN (1-742): 5.49e-175: 572: 23.27		POC1B_HUMAN (488-664): 5.31e-23: 104: 12.36
+	Hs
		903185 ACACA_HUMAN (1-746): 1.06e-175: 573: 22.40		WDR5_HUMAN (519-664): 4.67e-21: 96.8: 12.25
+	Hs
		135999 ACACB_HUMAN (1-742): 5.49e-175: 572: 23.27		WDR5_HUMAN (519-664): 4.67e-21: 96.8: 12.25
+	Hs
		136043 ACACB_HUMAN (1-742): 5.49e-175: 572: 23.27		WDR5B_HUMAN (536-664): 1.93e-19: 91.8: 15.39
+	Hs
		1024070 ACACA_HUMAN (1-746): 1.06e-175: 573: 22.40		SNR40_HUMAN (5-71): 6.38e-13: 72.5: 22.39
+	Hs
		136062 ACACB_HUMAN (1-742): 5.49e-175: 572: 23.27		SNR40_HUMAN (5-71): 6.38e-13: 72.5: 22.39
+	Hs
		398273 PCCA_HUMAN (1065-1178): 1.27e-34: 144: 30.44		WDTC1_HUMAN (1-677): 4.96e-133: 408: 100.00
+	Sc
		424570 PYR1_YEAST (19-420): 2.78e-58: 223: 16.83		COPB2_YEAST (6-292): 8.64e-44: 171: 16.50
+	Hs
		653407 PYR1_HUMAN (19-420): 1.96e-55: 214: 16.07		CHIP_HUMAN (357-493): 1.72e-38: 146: 30.66
+	Hs
		653325 PYR1_HUMAN (19-420): 1.96e-55: 214: 16.07		POC1B_HUMAN (488-664): 5.31e-23: 104: 12.36
+	Sc
		424323 PYR1_YEAST (19-420): 2.78e-58: 223: 16.83		STI1_YEAST (358-465): 1.12e-12: 72.9: 28.44