HitPredict

Interactor 1: CDK4 (P11802)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: RBL1 (P28749)
Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1)
Gene: RBL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.53	0.60	0.569

Property	Details
Experiments	22094256
Identification Methods	enzymatic study, protein kinase assay
Interaction Type	direct interaction, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005654 - nucleoplasm GO:0005667 - transcription regulator complex
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 303 Hs			1 1068
+	Hs
		625138 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		RBL1_HUMAN (1-1068): 0: 1528: 100.00
+	Hs
		660117 CDK6_HUMAN (5-300): 4.03e-127: 367: 70.03		RBL1_HUMAN (1-1068): 0: 1528: 100.00
+	Hs
		625392 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		RBL2_HUMAN (19-1068): 0: 1356: 50.32
+	Hs
		515411 CDK4_HUMAN (1-303): 2.42e-128: 369: 100.00		RBL2_HUMAN (19-1068): 0: 1356: 50.32
+	Hs
		960159 CDK6_HUMAN (5-300): 4.03e-127: 367: 70.03		RBL2_HUMAN (19-1068): 0: 1356: 50.32
+	Hs
		414172 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		RB_HUMAN (735-1046): 2.21e-85: 298: 28.88
+	Hs
		414244 CDK3_HUMAN (3-302): 7.81e-139: 395: 44.74		RB_HUMAN (735-1046): 2.21e-85: 298: 28.88
+	Mm
		527147 CDK2_MOUSE (3-301): 1.03e-135: 389: 37.89		RB_MOUSE (718-1046): 4.9e-86: 300: 28.32
+	Hs
		414126 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		RB_HUMAN (735-1046): 2.21e-85: 298: 28.88
+	Hs
		414144 CDK4_HUMAN (1-303): 2.42e-128: 369: 100.00		RB_HUMAN (735-1046): 2.21e-85: 298: 28.88
+	Mm
		527159 CDK6_MOUSE (5-300): 2.33e-127: 367: 69.70		RB_MOUSE (718-1046): 4.9e-86: 300: 28.32
+	Hs
		414245 CDK6_HUMAN (5-300): 4.03e-127: 367: 70.03		RB_HUMAN (735-1046): 2.21e-85: 298: 28.88
+	Mm
		527134 CDK4_MOUSE (1-299): 5.01e-126: 363: 95.65		RB_MOUSE (718-1046): 4.9e-86: 300: 28.32
+	Hs
		414246 CDK5_HUMAN (3-301): 5.52e-124: 357: 43.09		RB_HUMAN (735-1046): 2.21e-85: 298: 28.88
+	At
		621707 CDKA1_ARATH (3-302): 2.01e-129: 371: 44.26		RBR1_ARATH (742-1032): 4.95e-70: 255: 25.64
+	Dm
		1097887 Q94877_DROME (5-298): 1.83e-126: 365: 46.94		RBF_DROME (779-1028): 7.56e-72: 258: 31.47
+	At
		1106610 MPK6_ARATH (3-303): 1.42e-122: 358: 34.95		RBR1_ARATH (742-1032): 4.95e-70: 255: 25.64
+	At
		1106484 MPK5_ARATH (3-302): 2.25e-122: 357: 36.25		RBR1_ARATH (742-1032): 4.95e-70: 255: 25.64
+	Dm
		618441 CDK2_DROME (6-295): 8.61e-69: 218: 43.88		RBF_DROME (779-1028): 7.56e-72: 258: 31.47