HitPredict

Interactor 1: CDK4 (P11802)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.987

Property	Details
Experiments	26186194, 28514442, 17353931, 24292678, 8703009, 9150368, 33961781, 32707033, 16156789, 24189400, 24981860, 8666233, 21675959, 25036637, 21871133
Identification Methods	affinity chromatography technology, two hybrid, pull down, protein complementation assay, coimmunoprecipitation, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CDC37_M~Pkinase, CDC37_N~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 303 Hs			1 378
+	Hs
		625464 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		414935 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		960185 CDK6_HUMAN (5-300): 4.03e-127: 367: 70.03		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		1082824 Q6LC83_HUMAN (75-303): 7.08e-125: 357: 100.00		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		960287 CDK5_HUMAN (3-301): 5.52e-124: 357: 43.09		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Sp
		294078 CDK1_SCHPO (3-297): 2.72e-123: 356: 43.56		CDC37_SCHPO (2-355): 2.73e-87: 273: 17.35
+	Sc
		339332 CDK1_YEAST (4-297): 5.64e-119: 345: 42.38		CDC37_YEAST (2-320): 1.81e-73: 238: 18.34