Protein: PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha)

Gene: PI51A, PIP5K1A
Organism: Homo sapiens
Interactions: 172
UniProt ID: Q99755

Gene Ontology (top 5):
GO:0000285 - 1-phosphatidylinositol-3-phosphate 5-kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

872008

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

3

14

High-throughput

0.855

High

245812

PI51C
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

3

14

High-throughput

0.839

High

921564

PGTB2
Geranylgeranyl transferase type-2 subunit beta

3

2

High-throughput

0.667

High

1407188

ARI1
E3 ubiquitin-protein ligase ARIH1

3

5

High-throughput

0.667

High

1290674

ZCH18
Zinc finger CCCH domain-containing protein 18

3

1

High-throughput

0.662

High

375878

RASK
GTPase KRas

2

3

High-throughput

0.646

High

1358834

KBTB7
Kelch repeat and BTB domain-containing protein 7

3

0

High-throughput

0.634

High

1328661

KCD17
BTB/POZ domain-containing protein KCTD17

4

2

High-throughput

0.630

High

603349

KPCA
Protein kinase C alpha type

2

2

High-throughput

0.628

High

635370

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

2

2

High-throughput

0.628

High

1110546

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

2

2

High-throughput

0.628

High

1279146

RHG22
Rho GTPase-activating protein 22

2

4

High-throughput

0.628

High

1393309

SAHH3
Adenosylhomocysteinase 3

2

6

High-throughput

0.628

High

1397711

ZSC31
Zinc finger and SCAN domain-containing protein 31

2

1

High-throughput

0.628

High

1407152

KLDC3
Kelch domain-containing protein 3

2

1

High-throughput

0.628

High

1214847

PI5L1
Phosphatidylinositol 4-phosphate 5-kinase-like protein 1

1

13

Small-scale

0.618

High

238594

RAD21
Double-strand-break repair protein rad21 homolog

2

1

High-throughput

0.611

High

451562

CENPB
Major centromere autoantigen B

2

2

High-throughput

0.611

High

906341

GPC3
Glypican-3

2

1

High-throughput

0.611

High

1041643

TGBR3
Transforming growth factor beta receptor type 3

2

1

High-throughput

0.611

High

1325381

STAG2
Cohesin subunit SA-2

2

1

High-throughput

0.611

High

1357732

TRI41
E3 ubiquitin-protein ligase TRIM41

2

1

High-throughput

0.611

High

1395136

DCAF5
DDB1- and CUL4-associated factor 5

2

3

High-throughput

0.611

High

1339393

GP156
Probable G-protein coupled receptor 156

2

0

High-throughput

0.602

High

1390378

CCD97
Coiled-coil domain-containing protein 97

2

0

High-throughput

0.602

High

1407176

PFD2
Prefoldin subunit 2

2

0

High-throughput

0.602

High

1407182

ABT1
Activator of basal transcription 1

2

1

High-throughput

0.601

High

164425

NRP1
Neuropilin-1

2

0

High-throughput

0.585

High

1407187

NRX3A
Neurexin-3

2

2

High-throughput

0.584

High

58912

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

14

High-throughput

0.575

High

1407163

STPAP
Speckle targeted PIP5K1A-regulated poly(A) polymerase

1

0

Small-scale

0.568

High

861744

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

6

Small-scale

0.561

High

1407165

LN28A
Protein lin-28 homolog A

2

1

High-throughput

0.552

High

51766

ZBT7C
Zinc finger and BTB domain-containing protein 7C

1

1

High-throughput

0.536

High

176224

PER2
Period circadian protein homolog 2

1

1

High-throughput

0.536

High

191771

MAGB2
Melanoma-associated antigen B2

1

4

High-throughput

0.536

High

259066

DNJA2
DnaJ homolog subfamily A member 2

1

3

High-throughput

0.536

High

391425

FRIL
Ferritin light chain

1

3

High-throughput

0.536

High

487677

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.536

High

502497

H2A1
Histone H2A type 1

1

1

High-throughput

0.536

High

552680

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

2

High-throughput

0.536

High

718455

CD6
T-cell differentiation antigen CD6

1

3

High-throughput

0.536

High

1036680

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

4

High-throughput

0.536

High

1099497

SRSF6
Serine/arginine-rich splicing factor 6

1

2

High-throughput

0.536

High

1111432

DGKZ
Diacylglycerol kinase zeta

1

2

High-throughput

0.536

High

1144140

TEBP
Prostaglandin E synthase 3

1

2

High-throughput

0.536

High

1211275

SNPC4
snRNA-activating protein complex subunit 4

1

1

High-throughput

0.536

High

1325615

PGBD5
PiggyBac transposable element-derived protein 5

1

1

High-throughput

0.536

High

1350211

PREX1
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

1

3

High-throughput

0.536

High

1385974

ZN653
Zinc finger protein 653

1

2

High-throughput

0.536

High

1407169

MED4
Mediator of RNA polymerase II transcription subunit 4

1

3

High-throughput

0.536

High

1407184

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

2

High-throughput

0.536

High

549670

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.513

High

606030

CAN2
Calpain-2 catalytic subunit

1

0

High-throughput

0.513

High

693928

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.513

High

721735

GCH1
GTP cyclohydrolase 1

1

0

High-throughput

0.513

High

772979

MYH9
Myosin-9

1

0

High-throughput

0.513

High

970061

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.513

High

1153662

ZKSC8
Zinc finger protein with KRAB and SCAN domains 8

1

0

High-throughput

0.513

High

1158034

SNPC1
snRNA-activating protein complex subunit 1

1

0

High-throughput

0.513

High

1281456

ZN467
Zinc finger protein 467

1

0

High-throughput

0.513

High

1370970

SNPC3
snRNA-activating protein complex subunit 3

1

0

High-throughput

0.513

High

1407179

ITBP2
Integrin beta-1-binding protein 2

1

0

High-throughput

0.513

High

422973

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

1270960

RHOU
Rho-related GTP-binding protein RhoU

1

11

High-throughput

0.501

High

358895

AL1A1
Aldehyde dehydrogenase 1A1

1

0

High-throughput

0.493

High

1400298

CC85A
Coiled-coil domain-containing protein 85A

1

3

High-throughput

0.489

High

136968

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

3

High-throughput

0.479

High

225334

HTSF1
17S U2 SnRNP complex component HTATSF1

1

2

High-throughput

0.479

High

242709

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

315935

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

325072

HEXI1
Protein HEXIM1

1

2

High-throughput

0.479

High

346242

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

363769

EGFR
Epidermal growth factor receptor

1

1

Small-scale

0.479

High

374877

RASH
GTPase HRas

1

1

High-throughput

0.479

High

419162

H2A1B
Histone H2A type 1-B/E

1

1

High-throughput

0.479

High

463728

LYN
Tyrosine-protein kinase Lyn

1

1

High-throughput

0.479

High

473013

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

3

High-throughput

0.479

High

540641

LAMP1
Lysosome-associated membrane glycoprotein 1

1

4

High-throughput

0.479

High

562349

LAMP2
Lysosome-associated membrane glycoprotein 2

1

4

High-throughput

0.479

High

578537

BRAF
Serine/threonine-protein kinase B-raf

1

3

High-throughput

0.479

High

581255

RAC2
Ras-related C3 botulinum toxin substrate 2

1

8

High-throughput

0.479

High

601419

RHOQ
Rho-related GTP-binding protein RhoQ

1

11

High-throughput

0.479

High

710446

EPHA2
Ephrin type-A receptor 2

1

1

High-throughput

0.479

High

715736

MARCS
Myristoylated alanine-rich C-kinase substrate

1

1

High-throughput

0.479

High

845774

MUC18
Cell surface glycoprotein MUC18

1

1

High-throughput

0.479

High

953636

RAC3
Ras-related C3 botulinum toxin substrate 3

1

9

High-throughput

0.479

High

956458

RAB2A
Ras-related protein Rab-2A

1

2

High-throughput

0.479

High

970967

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

975200

ARF6
ADP-ribosylation factor 6

1

4

High-throughput

0.479

High

978248

RHOB
Rho-related GTP-binding protein RhoB

1

9

High-throughput

0.479

High

988650

RAC1
Ras-related C3 botulinum toxin substrate 1

1

9

High-throughput

0.479

High

1015714

RHOG
Rho-related GTP-binding protein RhoG

1

7

High-throughput

0.479

High

1087682

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

5

High-throughput

0.479

High

1194318

LARP7
La-related protein 7

1

3

High-throughput

0.479

High

1233444

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.479

High

1280438

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

6

High-throughput

0.479

High

1292803

SKAP1
Src kinase-associated phosphoprotein 1

1

5

High-throughput

0.479

High

1316578

PELP1
Proline-, glutamic acid- and leucine-rich protein 1

1

2

High-throughput

0.479

High

1396780

SNX27
Sorting nexin-27

1

4

High-throughput

0.479

High

1407158

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

3

High-throughput

0.479

High

1407161

RHOJ
Rho-related GTP-binding protein RhoJ

1

12

High-throughput

0.479

High

1407166

RHOF
Rho-related GTP-binding protein RhoF

1

12

High-throughput

0.479

High

1407167

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

6

Small-scale

0.479

High

1407170

TLR9
Toll-like receptor 9

1

2

Small-scale

0.479

High

1407172

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

1

4

High-throughput

0.479

High

1407175

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1407177

XPO7
Exportin-7

1

2

High-throughput

0.479

High

1407183

FZR1
Fizzy-related protein homolog

1

2

High-throughput

0.479

High

189797

STX7
Syntaxin-7

1

0

High-throughput

0.458

High

604174

CXA1
Gap junction alpha-1 protein

1

0

High-throughput

0.458

High

754960

H2B1B
Histone H2B type 1-B

1

0

High-throughput

0.458

High

1004178

CXAR
Coxsackievirus and adenovirus receptor

1

0

High-throughput

0.458

High

1041245

CAV1
Caveolin-1

1

0

High-throughput

0.458

High

1125386

FLNC
Filamin-C

1

0

High-throughput

0.458

High

1145078

RAB35
Ras-related protein Rab-35

1

0

High-throughput

0.458

High

1197686

MIDN
Midnolin

1

0

High-throughput

0.458

High

1333323

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

1334822

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

1388705

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

0

Small-scale

0.458

High

1407159

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

High-throughput

0.458

High

1407160

DNJC5
DnaJ homolog subfamily C member 5

1

0

High-throughput

0.458

High

1407173

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

288743

NPM3
Nucleoplasmin-3

1

1

High-throughput

0.445

High

351160

ECD
Protein ecdysoneless homolog

1

1

High-throughput

0.445

High

530279

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.445

High

1145341

RNPS1
RNA-binding protein with serine-rich domain 1

1

4

High-throughput

0.445

High

1151186

OASL
2'-5'-oligoadenylate synthase-like protein

1

3

High-throughput

0.445

High

1179358

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

1

High-throughput

0.445

High

1214244

KANK4
KN motif and ankyrin repeat domain-containing protein 4

1

3

High-throughput

0.445

High

1215354

DCAF8
DDB1- and CUL4-associated factor 8

1

4

High-throughput

0.445

High

1313916

DHX37
Probable ATP-dependent RNA helicase DHX37

1

1

High-throughput

0.445

High

1334357

IN80E
INO80 complex subunit E

1

1

High-throughput

0.445

High

1393397

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

1

High-throughput

0.445

High

1407154

RBM42
RNA-binding protein 42

1

3

High-throughput

0.445

High

1407155

ZN692
Zinc finger protein 692

1

2

High-throughput

0.445

High

1407164

YTDC2
3'-5' RNA helicase YTHDC2

1

1

High-throughput

0.445

High

1407168

NRX3B
Neurexin-3-beta

1

1

High-throughput

0.445

High

1407178

FBX3
F-box only protein 3

1

1

High-throughput

0.445

High

1407185

YBOX2
Y-box-binding protein 2

1

1

High-throughput

0.445

High

1407181

CAPS1
Calcium-dependent secretion activator 1

1

0

High-throughput

0.438

High

1407174

HECW2
E3 ubiquitin-protein ligase HECW2

1

6

High-throughput

0.437

High

208352

RRP8
Ribosomal RNA-processing protein 8

1

0

High-throughput

0.426

High

240158

FGF17
Fibroblast growth factor 17

1

0

High-throughput

0.426

High

616798

SDC1
Syndecan-1

1

0

High-throughput

0.426

High

809805

RS19
Small ribosomal subunit protein eS19

1

0

High-throughput

0.426

High

860910

RS10
Small ribosomal subunit protein eS10

1

0

High-throughput

0.426

High

1005760

RPP38
Ribonuclease P protein subunit p38

1

0

High-throughput

0.426

High

1037333

H11
Histone H1.1

1

0

High-throughput

0.426

High

1112142

KRR1
KRR1 small subunit processome component homolog

1

0

High-throughput

0.426

High

1132420

CASP8
Caspase-8

1

0

High-throughput

0.426

High

1209561

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1231577

TBC3G
TBC1 domain family member 3G

1

0

High-throughput

0.426

High

1249712

CLC4G
C-type lectin domain family 4 member G

1

0

Small-scale

0.426

High

1340446

DDX55
ATP-dependent RNA helicase DDX55

1

0

High-throughput

0.426

High

1407153

PYM1
Partner of Y14 and mago

1

0

High-throughput

0.426

High

1407156

NOC4L
Nucleolar complex protein 4 homolog

1

0

High-throughput

0.426

High

1407162

ESF1
ESF1 homolog

1

0

High-throughput

0.426

High

1407186

RRP7A
Ribosomal RNA-processing protein 7 homolog A

1

0

High-throughput

0.426

High

1009296

PRR3
Proline-rich protein 3

1

2

High-throughput

0.407

High

1390919

LRC46
Leucine-rich repeat-containing protein 46

1

5

High-throughput

0.407

High

1407171

GFOD1
Glucose-fructose oxidoreductase domain-containing protein 1

3

0

High-throughput

0.347

High

1249632

PXDC2
Plexin domain-containing protein 2

2

0

High-throughput

0.313

High

321933

FRYL
Protein furry homolog-like

1

0

High-throughput

0.279

Low

1202494

RUN3A
RUN domain-containing protein 3A

1

0

High-throughput

0.279

Low

1278628

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

1407157

TMED9
Transmembrane emp24 domain-containing protein 9

1

0

High-throughput

0.279

Low

1215788

RC3H1
Roquin-1

1

0

High-throughput

0.249

Low

1381945

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.249

Low

1334278

S38A9
Neutral amino acid transporter 9

1

0

High-throughput

0.232

Low

1358273

TFB1M
Dimethyladenosine transferase 1, mitochondrial

1

0

High-throughput

0.232

Low

1407180

PNMA2
Paraneoplastic antigen Ma2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025