HitPredict

Interactor 1: CDK4 (P11802)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: Q96TE0 (Q96TE0)
Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1)
Gene: Q96TE0

Species: Homo sapiens

Source: dip

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	8822197
Identification Methods	coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CDI~Pkinase
Common GO terms	GO:0000082 - G1/S transition of mitotic cell cycle GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 303 Hs			1 198
+	Hs
		625207 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		CDN1B_HUMAN (1-198): 9.11e-86: 253: 98.99
+	Hs
		804104 CDK3_HUMAN (3-302): 7.81e-139: 395: 44.74		CDN1B_HUMAN (1-198): 9.11e-86: 253: 98.99
+	Rn
		139842 CDK2_RAT (3-301): 5.1e-145: 411: 44.22		O08769_RAT (1-197): 3.27e-78: 234: 85.79
+	Mm
		803840 CDK2_MOUSE (3-301): 1.03e-135: 389: 37.89		CDN1B_MOUSE (1-197): 2.74e-80: 239: 86.29
+	Hs
		414811 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		CDN1B_HUMAN (1-198): 9.11e-86: 253: 98.99
+	Hs
		515368 CDK4_HUMAN (1-303): 2.42e-128: 369: 100.00		CDN1B_HUMAN (1-198): 9.11e-86: 253: 98.99
+	Hs
		625186 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		CDN1A_HUMAN (17-167): 2.06e-47: 154: 28.93
+	Xl
		1153623 Q6IRQ7_XENLA (3-302): 2.31e-142: 404: 42.76		Q91646_XENLA (14-190): 1.76e-44: 148: 26.00
+	Xl
		616668 CDK2_XENLA (3-302): 4.6e-142: 403: 43.09		Q91646_XENLA (14-190): 1.76e-44: 148: 26.00
+	Hs
		758188 CDK3_HUMAN (3-302): 7.81e-139: 395: 44.74		CDN1A_HUMAN (17-167): 2.06e-47: 154: 28.93
+	Mm
		763415 CDK2_MOUSE (3-301): 1.03e-135: 389: 37.89		CDN1A_MOUSE (17-167): 7.81e-50: 160: 29.87
+	Mm
		509470 CDK1_MOUSE (3-300): 1.06e-128: 370: 42.24		CDN1A_MOUSE (17-167): 7.81e-50: 160: 29.87
+	Mm
		763419 CDK6_MOUSE (5-300): 2.33e-127: 367: 69.70		CDN1A_MOUSE (17-167): 7.81e-50: 160: 29.87
+	Hs
		414796 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		CDN1A_HUMAN (17-167): 2.06e-47: 154: 28.93
+	Hs
		515361 CDK4_HUMAN (1-303): 2.42e-128: 369: 100.00		CDN1A_HUMAN (17-167): 2.06e-47: 154: 28.93
+	Xl
		724512 CDK1A_XENLA (3-302): 1.37e-129: 372: 41.64		Q91646_XENLA (14-190): 1.76e-44: 148: 26.00
+	Hs
		625237 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		CDN1C_HUMAN (10-125): 1.31e-27: 107: 36.50
+	Hs
		836898 CDK3_HUMAN (3-302): 7.81e-139: 395: 44.74		CDN1C_HUMAN (10-125): 1.31e-27: 107: 36.50
+	Hs
		414825 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		CDN1C_HUMAN (10-125): 1.31e-27: 107: 36.50
+	Hs
		515378 CDK4_HUMAN (1-303): 2.42e-128: 369: 100.00		CDN1C_HUMAN (10-125): 1.31e-27: 107: 36.50