HitPredict

Interactor 1: PABP1 (P11940)
Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)
Gene: PABPC1

Interactor 2: U2AF2 (P26368)
Splicing factor U2AF 65 kDa subunit (U2 auxiliary factor 65 kDa subunit) (hU2AF(65)) (hU2AF65) (U2 snRNP auxiliary factor large subunit)
Gene: U2AF2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	26641092
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 636 Hs			1 475
+	Hs
		641756 PABP4_HUMAN (1-635): 0: 534: 74.69		U2AF2_HUMAN (1-475): 3.12e-94: 294: 100.00
+	Hs
		516484 PABP1_HUMAN (1-636): 0: 582: 100.00		ELAV2_HUMAN (116-470): 6.19e-71: 230: 13.42
+	Hs
		1031344 PABP4_HUMAN (1-635): 0: 534: 74.69		ELAV1_HUMAN (149-471): 2.84e-73: 235: 14.79
+	Hs
		1020249 PABP4_HUMAN (1-635): 0: 534: 74.69		ELAV2_HUMAN (116-470): 6.19e-71: 230: 13.42
+	Hs
		516518 PABP1_HUMAN (1-636): 0: 582: 100.00		RBM39_HUMAN (10-471): 4.93e-48: 175: 19.16
+	Mm
		665745 PABP1_MOUSE (1-636): 0: 581: 99.69		TIA1_MOUSE (253-475): 4.2e-36: 139: 15.70
+	Hs
		516471 PABP1_HUMAN (1-636): 0: 582: 100.00		TIAR_HUMAN (251-473): 6.95e-33: 130: 14.67
+	Hs
		1031328 PABP4_HUMAN (1-635): 0: 534: 74.69		RBM39_HUMAN (10-471): 4.93e-48: 175: 19.16
+	Hs
		516730 PABP1_HUMAN (1-636): 0: 582: 100.00		PUF60_HUMAN (92-474): 7.84e-23: 103: 21.50
+	Hs
		516495 PABP1_HUMAN (1-636): 0: 582: 100.00		PABP4_HUMAN (41-251): 2.07e-19: 93: 12.78
+	Hs
		516339 PABP1_HUMAN (1-636): 0: 582: 100.00		PABP1_HUMAN (41-247): 3.26e-19: 92.6: 14.35
+	Hs
		516689 PABP1_HUMAN (1-636): 0: 582: 100.00		PABP3_HUMAN (41-247): 1.1e-18: 91.1: 14.80
+	Hs
		1031490 PABP4_HUMAN (1-635): 0: 534: 74.69		PUF60_HUMAN (92-474): 7.84e-23: 103: 21.50
+	Zm
		8143 A0A1D6ELH4_MAIZE (2-467): 9.33e-68: 235: 25.36		A0A1D6ELH4_MAIZE (87-419): 6.02e-48: 176: 15.27
+	Hs
		680455 TIA1_HUMAN (4-172): 1.71e-42: 159: 28.57		ELAV1_HUMAN (149-471): 2.84e-73: 235: 14.79
+	Hs
		680422 TIA1_HUMAN (4-172): 1.71e-42: 159: 28.57		TIA1_HUMAN (253-475): 5.63e-36: 138: 15.70
+	Hs
		680439 TIA1_HUMAN (4-172): 1.71e-42: 159: 28.57		TIAR_HUMAN (251-473): 6.95e-33: 130: 14.67
+	Hs
		516635 PABP5_HUMAN (6-179): 5.04e-39: 149: 25.26		PABP1_HUMAN (41-247): 3.26e-19: 92.6: 14.35