Protein: RM53
Large ribosomal subunit protein mL53 (39S ribosomal protein L53, mitochondrial) (L53mt) (MRP-L53)

Gene: RM53, MRPL53
Organism: Homo sapiens
Interactions: 163
UniProt ID: Q96EL3

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005762 - mitochondrial large ribosomal subunit
GO:0032543 - mitochondrial translation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1281309

RM10
Large ribosomal subunit protein uL10m

3

1

High-throughput

0.861

High

914708

RM12
Large ribosomal subunit protein bL12m

7

1

High-throughput

0.742

High

1389293

RT18A
Large ribosomal subunit protein mL66

7

2

High-throughput

0.740

High

1389286

RT30
Large ribosomal subunit protein mL65

4

1

High-throughput

0.691

High

1389268

RM04
Large ribosomal subunit protein uL4m

3

1

High-throughput

0.667

High

1389310

RM11
Large ribosomal subunit protein uL11m

4

0

High-throughput

0.657

High

1328257

RM50
Large ribosomal subunit protein mL50

3

0

High-throughput

0.646

High

1389269

RM01
Large ribosomal subunit protein uL1m

2

1

High-throughput

0.628

High

856340

IF2M
Translation initiation factor IF-2, mitochondrial

2

1

High-throughput

0.611

High

729398

HNRH1
Heterogeneous nuclear ribonucleoprotein H

3

2

High-throughput

0.607

High

1389267

RM09
Large ribosomal subunit protein bL9m

2

0

High-throughput

0.602

High

1123377

ICT1
Large ribosomal subunit protein mL62

2

0

High-throughput

0.585

High

1051287

KPCZ
Protein kinase C zeta type

3

1

High-throughput

0.578

High

1213311

RM02
Large ribosomal subunit protein uL2m

2

0

High-throughput

0.576

High

1287524

RM52
Large ribosomal subunit protein mL52

2

0

High-throughput

0.576

High

1389275

RM18
Large ribosomal subunit protein uL18m

2

0

High-throughput

0.576

High

1389312

RM42
Large ribosomal subunit protein mL42

2

0

High-throughput

0.576

High

1290931

TAXB1
Tax1-binding protein 1

1

1

High-throughput

0.573

High

1389305

MRES1
Mitochondrial transcription rescue factor 1

2

0

High-throughput

0.559

High

372814

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.558

High

192389

GSC2
Homeobox protein goosecoid-2

2

1

High-throughput

0.553

High

882357

RM19
Large ribosomal subunit protein bL19m

1

1

High-throughput

0.536

High

1158262

RM23
Large ribosomal subunit protein uL23m

1

1

High-throughput

0.536

High

1312728

RM41
Large ribosomal subunit protein mL41

1

1

High-throughput

0.536

High

1349527

RM30
Large ribosomal subunit protein uL30m

1

1

High-throughput

0.536

High

1387924

RM38
Large ribosomal subunit protein mL38

1

1

High-throughput

0.536

High

1389264

RM32
Large ribosomal subunit protein bL32m

1

1

High-throughput

0.536

High

1389265

RM20
Large ribosomal subunit protein bL20m

1

1

High-throughput

0.536

High

1389290

RM17
Large ribosomal subunit protein bL17m

1

1

High-throughput

0.536

High

835728

KPCI
Protein kinase C iota type

2

1

High-throughput

0.521

High

76013

B4DEF8
Large ribosomal subunit protein mL45

1

0

High-throughput

0.513

High

280051

RM33
Large ribosomal subunit protein bL33m

1

0

High-throughput

0.513

High

477837

RM03
Large ribosomal subunit protein uL3m

1

0

High-throughput

0.513

High

539384

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

0

High-throughput

0.513

High

1094082

RM28
Large ribosomal subunit protein bL28m

1

0

High-throughput

0.513

High

1104053

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.513

High

1141528

OXA1L
Mitochondrial inner membrane protein OXA1L

1

0

High-throughput

0.513

High

1196137

RM51
Large ribosomal subunit protein mL51

1

0

High-throughput

0.513

High

1240536

RM54
Large ribosomal subunit protein mL54

1

0

High-throughput

0.513

High

1275815

RM21
Large ribosomal subunit protein bL21m

1

0

High-throughput

0.513

High

1281114

RM55
Large ribosomal subunit protein mL55

1

0

High-throughput

0.513

High

1331660

RM43
Large ribosomal subunit protein mL43

1

0

High-throughput

0.513

High

1347038

G45IP
Large ribosomal subunit protein mL64

1

0

High-throughput

0.513

High

1382273

RM24
Large ribosomal subunit protein uL24m

1

0

High-throughput

0.513

High

1388980

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.513

High

1389255

RM48
Large ribosomal subunit protein mL48

1

0

High-throughput

0.513

High

1389256

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.513

High

1389258

RM34
Large ribosomal subunit protein bL34m

1

0

High-throughput

0.513

High

1389259

RT63
Large ribosomal subunit protein mL63

1

0

High-throughput

0.513

High

1389266

RM13
Large ribosomal subunit protein uL13m

1

0

High-throughput

0.513

High

1389271

RM37
Large ribosomal subunit protein mL37

1

0

High-throughput

0.513

High

1389277

RM46
Large ribosomal subunit protein mL46

1

0

High-throughput

0.513

High

1389282

RM44
Large ribosomal subunit protein mL44

1

0

High-throughput

0.513

High

1389283

MRM3
rRNA methyltransferase 3, mitochondrial

1

0

High-throughput

0.513

High

1389284

RM47
Large ribosomal subunit protein uL29m

1

0

High-throughput

0.513

High

1389288

RM40
Large ribosomal subunit protein mL40

1

0

High-throughput

0.513

High

1389297

RM22
Large ribosomal subunit protein uL22m

1

0

High-throughput

0.513

High

1389299

RM16
Large ribosomal subunit protein uL16m

1

0

High-throughput

0.513

High

1389300

RM39
Large ribosomal subunit protein mL39

1

0

High-throughput

0.513

High

1389302

RM35
Large ribosomal subunit protein bL35m

1

0

High-throughput

0.513

High

1389303

RM15
Large ribosomal subunit protein uL15m

1

0

High-throughput

0.513

High

1389304

RM27
Large ribosomal subunit protein bL27m

1

0

High-throughput

0.513

High

516948

GAL3A
Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial

1

0

High-throughput

0.493

High

422853

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

282038

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.479

High

287348

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

1083700

MPPA
Mitochondrial-processing peptidase subunit alpha

1

1

High-throughput

0.479

High

1087493

GRSF1
G-rich sequence factor 1

1

2

High-throughput

0.479

High

1135915

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

3

High-throughput

0.479

High

1272959

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

3

High-throughput

0.479

High

1381105

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

1

High-throughput

0.479

High

1381669

FAKD4
FAST kinase domain-containing protein 4

1

3

High-throughput

0.479

High

1383537

MCUR1
Mitochondrial calcium uniporter regulator 1

1

1

High-throughput

0.479

High

1389257

EFGM
Elongation factor G, mitochondrial

1

1

High-throughput

0.479

High

1389272

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

1389273

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.479

High

1389278

MTRFR
Mitochondrial translation release factor in rescue

1

2

High-throughput

0.479

High

1389301

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

3

High-throughput

0.479

High

1389306

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

66263

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

High-throughput

0.458

High

183700

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.458

High

283931

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

0

High-throughput

0.458

High

350950

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

532858

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

828892

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

841872

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

851985

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

882818

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.458

High

1024135

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

1048631

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1058198

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1117803

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

1142625

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

1241324

CH082
UPF0598 protein C8orf82

1

0

High-throughput

0.458

High

1310303

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.458

High

1384846

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

1385993

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

0

High-throughput

0.458

High

1387202

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

0

High-throughput

0.458

High

1388234

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

1388362

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

1389254

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

0

High-throughput

0.458

High

1389260

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

1389261

MTG1
Mitochondrial ribosome-associated GTPase 1

1

0

High-throughput

0.458

High

1389262

TR61B
tRNA

1

0

High-throughput

0.458

High

1389263

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

1389270

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

1389276

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

1389280

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1389281

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

1389287

NGRN
Neugrin

1

0

High-throughput

0.458

High

1389289

XPP3
Xaa-Pro aminopeptidase 3

1

0

High-throughput

0.458

High

1389291

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

1389295

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

0

High-throughput

0.458

High

1389296

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

406486

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.437

High

653499

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

1389292

ATD3A
ATPase family AAA domain-containing protein 3A

1

0

High-throughput

0.426

High

516364

CALM1
Calmodulin-1

1

3

High-throughput

0.407

High

516442

CALM2
Calmodulin-2

1

3

High-throughput

0.407

High

516570

CALM3
Calmodulin-3

1

3

High-throughput

0.407

High

122830

KIF2A
Kinesin-like protein KIF2A

3

0

High-throughput

0.352

High

1389309

ADIP
Afadin- and alpha-actinin-binding protein

2

0

High-throughput

0.330

High

685301

PAX6
Paired box protein Pax-6

2

0

High-throughput

0.316

High

1086669

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

2

0

High-throughput

0.316

High

1147240

ELOB
Elongin-B

2

0

High-throughput

0.316

High

1329224

ANR29
Ankyrin repeat domain-containing protein 29

2

0

High-throughput

0.316

High

1341218

IKBD
NF-kappa-B inhibitor delta

2

0

High-throughput

0.316

High

1389294

THAP1
THAP domain-containing protein 1

2

0

High-throughput

0.316

High

1389308

IKZF3
Zinc finger protein Aiolos

1

0

High-throughput

0.299

High

635742

RASA1
Ras GTPase-activating protein 1

2

0

High-throughput

0.298

High

1218387

ARHGG
Rho guanine nucleotide exchange factor 16

2

0

High-throughput

0.298

High

214328

MSI1H
RNA-binding protein Musashi homolog 1

1

0

High-throughput

0.279

Low

317298

STK10
Serine/threonine-protein kinase 10

1

0

High-throughput

0.279

Low

343007

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.279

Low

596293

H12
Histone H1.2

1

0

High-throughput

0.279

Low

682574

S100P
Protein S100-P

1

0

High-throughput

0.279

Low

944894

PCBP4
Poly(rC)-binding protein 4

1

0

High-throughput

0.279

Low

1326025

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.279

Low

1336270

LS14A
Protein LSM14 homolog A

1

0

High-throughput

0.279

Low

1389274

UBP44
Ubiquitin carboxyl-terminal hydrolase 44

1

0

High-throughput

0.279

Low

1389298

BABA1
BRISC and BRCA1-A complex member 1

1

0

High-throughput

0.279

Low

1389311

FA32A
Protein FAM32A

1

0

High-throughput

0.279

Low

157721

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

294162

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

331227

KI20A
Kinesin-like protein KIF20A

1

0

High-throughput

0.249

Low

447306

NPM
Nucleophosmin

1

0

High-throughput

0.249

Low

472969

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.249

Low

650346

FGFR3
Fibroblast growth factor receptor 3

1

0

High-throughput

0.249

Low

755616

TTK
Dual specificity protein kinase TTK

1

0

High-throughput

0.249

Low

947248

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.249

Low

965155

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

970906

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

1194275

LARP7
La-related protein 7

1

0

High-throughput

0.249

Low

1215764

RC3H1
Roquin-1

1

0

High-throughput

0.249

Low

1255018

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1271789

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.249

Low

1380713

RL36L
Ribosomal protein eL42-like

1

0

High-throughput

0.249

Low

1389279

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1389307

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

994715

YBOX1
Y-box-binding protein 1

1

0

Small-scale

0.232

Low

1280805

S35E3
Solute carrier family 35 member E3

1

0

High-throughput

0.232

Low

1292277

S2611
Sodium-independent sulfate anion transporter

1

0

High-throughput

0.232

Low

1389285

S40A1
Ferroportin

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025