HitPredict

Interactor 1: PABP1 (P11940)
Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)
Gene: PABPC1

Interactor 2: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.634

Property	Details
Experiments	16782705, 26831064
Identification Methods	affinity chromatography technology, far western blotting, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:1990904 - ribonucleoprotein complex
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 636 Hs			1 1863
+	Hs
		749450 PABP4_HUMAN (1-635): 0: 534: 74.69		BRCA1_HUMAN (1-1863): 0: 1570: 100.00
+	Hs
		582105 NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33		BRCA1_HUMAN (1-1863): 0: 1570: 100.00
+	Hs
		1031425 PABP4_HUMAN (1-635): 0: 534: 74.69		TRI11_HUMAN (11-390): 3.9e-74: 257: 11.49
+	Hs
		1119142 PAP1L_HUMAN (1-628): 9.51e-166: 489: 68.20		TRI11_HUMAN (11-390): 3.9e-74: 257: 11.49
+	Hs
		516681 PABP1_HUMAN (1-636): 0: 582: 100.00		TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30
+	Hs
		1031451 PABP4_HUMAN (1-635): 0: 534: 74.69		TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30
+	Hs
		680481 TIA1_HUMAN (4-172): 1.71e-42: 159: 28.57		TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30
+	Hs
		582480 NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33		TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30