HitPredict

Interactor 1: PABP1 (P11940)
Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)
Gene: PABPC1

Interactor 2: TRA2B (P62995)
Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B)
Gene: TRA2B

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29395067
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0003729 - mRNA binding GO:0005634 - nucleus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 636 Hs			1 288
+	Hs
		516502 PABP1_HUMAN (1-636): 0: 582: 100.00		TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06
+	Hs
		516744 PABP1_HUMAN (1-636): 0: 582: 100.00		PPIE_HUMAN (118-201): 7.87e-27: 107: 36.91
+	Hs
		516484 PABP1_HUMAN (1-636): 0: 582: 100.00		ELAV2_HUMAN (52-244): 6.85e-24: 101: 20.00
+	Hs
		516495 PABP1_HUMAN (1-636): 0: 582: 100.00		PABP4_HUMAN (109-246): 4.69e-22: 97.6: 21.28
+	Hs
		516339 PABP1_HUMAN (1-636): 0: 582: 100.00		PABP1_HUMAN (109-246): 8.28e-22: 96.8: 21.99
+	Hs
		516689 PABP1_HUMAN (1-636): 0: 582: 100.00		PABP3_HUMAN (109-246): 1.1e-19: 90.7: 19.86
+	Hs
		516471 PABP1_HUMAN (1-636): 0: 582: 100.00		TIAR_HUMAN (73-272): 5.47e-20: 90.6: 14.00
+	Hs
		516518 PABP1_HUMAN (1-636): 0: 582: 100.00		RBM39_HUMAN (15-248): 3.58e-18: 86.1: 21.83
+	Mm
		665745 PABP1_MOUSE (1-636): 0: 581: 99.69		TIA1_MOUSE (113-248): 1.05e-17: 84.1: 18.42
+	Hs
		1031314 PABP4_HUMAN (1-635): 0: 534: 74.69		TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06
+	Hs
		516511 PABP1_HUMAN (1-636): 0: 582: 100.00		HNRPD_HUMAN (106-178): 6.05e-11: 64: 26.03
+	Hs
		1020249 PABP4_HUMAN (1-635): 0: 534: 74.69		ELAV2_HUMAN (52-244): 6.85e-24: 101: 20.00
+	Hs
		1031328 PABP4_HUMAN (1-635): 0: 534: 74.69		RBM39_HUMAN (15-248): 3.58e-18: 86.1: 21.83
+	Zm
		8143 A0A1D6ELH4_MAIZE (2-467): 9.33e-68: 235: 25.36		A0A1D6ELH4_MAIZE (84-265): 2.59e-18: 86.8: 16.76
+	Sc
		376562 PABP_YEAST (2-335): 1.06e-64: 225: 26.71		PABP_YEAST (98-206): 7.98e-20: 91.1: 19.27
+	Hs
		680439 TIA1_HUMAN (4-172): 1.71e-42: 159: 28.57		TIAR_HUMAN (73-272): 5.47e-20: 90.6: 14.00
+	Hs
		680422 TIA1_HUMAN (4-172): 1.71e-42: 159: 28.57		TIA1_HUMAN (113-248): 8.75e-18: 84.1: 18.42
+	Hs
		680450 TIA1_HUMAN (4-172): 1.71e-42: 159: 28.57		HNRPD_HUMAN (106-178): 6.05e-11: 64: 26.03