Protein: SH2B1
SH2B adapter protein 1 (Pro-rich, PH and SH2 domain-containing signaling mediator) (PSM) (SH2 domain-containing protein 1B)

Gene: SH2B1
Organism: Homo sapiens
Interactions: 33
UniProt ID: Q9NRF2

Gene Ontology (top 5):
GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0030032 - lamellipodium assembly

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

253385

JAK2
Tyrosine-protein kinase JAK2

5

20

Small-scale

0.934

High

363907

EGFR
Epidermal growth factor receptor

5

20

Small-scale

0.916

High

987968

GRB2
Growth factor receptor-bound protein 2

4

20

Small-scale

0.887

High

439857

INSR
Insulin receptor

3

20

Small-scale

0.876

High

412664

NTRK1
High affinity nerve growth factor receptor

2

20

Small-scale

0.800

High

220310

FRS3
Fibroblast growth factor receptor substrate 3

2

20

High-throughput

0.743

High

772523

IRS1
Insulin receptor substrate 1

2

20

Small-scale

0.727

High

154441

SH2B2
SH2B adapter protein 2

1

19

Small-scale

0.713

High

943623

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

13

High-throughput

0.698

High

472134

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.692

High

1382391

SPSB4
SPRY domain-containing SOCS box protein 4

1

11

High-throughput

0.691

High

411073

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

641687

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.647

High

855773

CRK
Adapter molecule crk

1

20

High-throughput

0.647

High

1145787

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

465662

IGF1R
Insulin-like growth factor 1 receptor

1

20

Small-scale

0.621

High

1159549

NTRK2
BDNF/NT-3 growth factors receptor

1

20

Small-scale

0.621

High

1448423

SH2B1
SH2B adapter protein 1

1

18

Small-scale

0.621

High

650438

FGFR3
Fibroblast growth factor receptor 3

1

20

Small-scale

0.618

High

827938

STAT3
Signal transducer and activator of transcription 3

1

14

Small-scale

0.618

High

1448424

IRS2
Insulin receptor substrate 2

1

20

Small-scale

0.618

High

1356247

FRS2
Fibroblast growth factor receptor substrate 2

1

20

Small-scale

0.575

High

1448425

CSAD
Cysteine sulfinic acid decarboxylase

2

4

High-throughput

0.542

High

1432407

RHBG
Ammonium transporter Rh type B

1

2

High-throughput

0.541

High

1034700

MEF2A
Myocyte-specific enhancer factor 2A

1

0

High-throughput

0.513

High

1228724

C102B
Coiled-coil domain-containing protein 102B

1

14

High-throughput

0.489

High

1218511

K0319
Dyslexia-associated protein KIAA0319

1

0

Small-scale

0.486

High

799501

BRCA1
Breast cancer type 1 susceptibility protein

1

17

Small-scale

0.479

High

831491

CCNF
Cyclin-F

1

4

High-throughput

0.479

High

516371

CALM1
Calmodulin-1

1

3

High-throughput

0.445

High

516451

CALM2
Calmodulin-2

1

3

High-throughput

0.445

High

516592

CALM3
Calmodulin-3

1

3

High-throughput

0.445

High


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Last updated: 11Aug2025