HitPredict

Interactor 1: PABP1 (P11940)
Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)
Gene: PABPC1

Interactor 2: TADBP (Q13148)
TAR DNA-binding protein 43 (TDP-43)
Gene: TARDBP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.873

Property	Details
Experiments	34349018, 35235311, 35007165, 20020773
Identification Methods	cross-linking study, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0003730 - mRNA 3'-UTR binding GO:0005634 - nucleus GO:0010494 - cytoplasmic stress granule
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 636 Hs			1 414
+	Hs
		161948 PABP1_HUMAN (1-636): 0: 582: 100.00		HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60
+	Hs
		516424 PABP1_HUMAN (1-636): 0: 582: 100.00		ROA3_HUMAN (98-269): 2.33e-69: 225: 28.57
+	Hs
		1025728 PABP4_HUMAN (1-635): 0: 534: 74.69		TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00
+	Hs
		162035 PABP4_HUMAN (1-635): 0: 534: 74.69		HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60
+	Hs
		516495 PABP1_HUMAN (1-636): 0: 582: 100.00		PABP4_HUMAN (98-274): 3.77e-37: 144: 19.02
+	Hs
		474021 PABP4_HUMAN (1-635): 0: 534: 74.69		PAB4L_HUMAN (2-276): 8.18e-56: 189: 16.96
+	Mm
		665745 PABP1_MOUSE (1-636): 0: 581: 99.69		TIA1_MOUSE (99-413): 1.08e-36: 139: 12.92
+	Hs
		516339 PABP1_HUMAN (1-636): 0: 582: 100.00		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95
+	Hs
		516689 PABP1_HUMAN (1-636): 0: 582: 100.00		PABP3_HUMAN (2-382): 7.84e-31: 126: 16.41
+	Hs
		516511 PABP1_HUMAN (1-636): 0: 582: 100.00		HNRPD_HUMAN (81-238): 5.59e-21: 95.1: 35.93
+	Dm
		597049 PABP_DROME (2-448): 6.58e-63: 221: 25.21		RB27C_DROME (99-400): 4.23e-73: 236: 28.17
+	Sc
		376562 PABP_YEAST (2-335): 1.06e-64: 225: 26.71		PABP_YEAST (86-269): 2.74e-34: 136: 21.88
+	Zm
		8143 A0A1D6ELH4_MAIZE (2-467): 9.33e-68: 235: 25.36		A0A1D6ELH4_MAIZE (74-268): 1.5e-29: 122: 17.24
+	Hs
		474034 PABP5_HUMAN (6-179): 5.04e-39: 149: 25.26		PAB4L_HUMAN (2-276): 8.18e-56: 189: 16.96
+	Sc
		376993 PABP_YEAST (2-335): 1.06e-64: 225: 26.71		HRP1_YEAST (101-289): 6.38e-20: 93.6: 31.50
+	Hs
		680422 TIA1_HUMAN (4-172): 1.71e-42: 159: 28.57		TIA1_HUMAN (99-413): 2.4e-38: 144: 13.76
+	Hs
		516635 PABP5_HUMAN (6-179): 5.04e-39: 149: 25.26		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95
+	Hs
		680450 TIA1_HUMAN (4-172): 1.71e-42: 159: 28.57		HNRPD_HUMAN (81-238): 5.59e-21: 95.1: 35.93