HitPredict

Interactor 1: PABP1 (P11940)
Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)
Gene: PABPC1

Interactor 2: IF4A2 (Q14240)
Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2)
Gene: EIF4A2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	17353931, 29395067
Identification Methods	affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005829 - cytosol
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 636 Hs			1 407
+	Hs
		516434 PABP1_HUMAN (1-636): 0: 582: 100.00		IF4A1_HUMAN (3-407): 2.35e-159: 456: 89.88
+	Hs
		892791 PABP4_HUMAN (1-635): 0: 534: 74.69		IF4A1_HUMAN (3-407): 2.35e-159: 456: 89.88
+	Hs
		133858 PABP1_HUMAN (1-636): 0: 582: 100.00		DDX3X_HUMAN (2-406): 3.77e-128: 385: 29.51
+	Hs
		516391 PABP1_HUMAN (1-636): 0: 582: 100.00		IF4A3_HUMAN (3-407): 2.28e-130: 382: 67.65
+	Hs
		134018 PABP4_HUMAN (1-635): 0: 534: 74.69		DDX3X_HUMAN (2-406): 3.77e-128: 385: 29.51
+	Hs
		1031325 PABP4_HUMAN (1-635): 0: 534: 74.69		IF4A2_HUMAN (1-407): 2.49e-129: 380: 100.00
+	Mm
		857295 TIA1_MOUSE (4-172): 1.01e-34: 137: 27.51		IF4A1_MOUSE (3-407): 2.35e-159: 456: 89.88
+	Mm
		857323 TIA1_MOUSE (4-172): 1.01e-34: 137: 27.51		DDX17_MOUSE (25-407): 6.02e-132: 395: 31.20
+	Sc
		376792 PABP_YEAST (2-335): 1.06e-64: 225: 26.71		DHH1_YEAST (33-403): 1.13e-98: 305: 43.67
+	Mm
		857351 TIA1_MOUSE (4-172): 1.01e-34: 137: 27.51		Q8BTS0_MOUSE (22-407): 5.62e-132: 393: 30.96
+	Hs
		571302 NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33		DDX5_HUMAN (10-407): 3.86e-132: 394: 30.30
+	Tc
		1116214 Q4E4I9_TRYCC (2-300): 5.21e-60: 212: 29.11		Q4DIE1_TRYCC (35-400): 4.98e-88: 274: 39.51
+	Hs
		133876 NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33		DDX3X_HUMAN (2-406): 3.77e-128: 385: 29.51