HitPredict

Interactor 1: PCNA (P12004)
Proliferating cell nuclear antigen (PCNA) (Cyclin)
Gene: PCNA

Interactor 2: MLH1 (P40692)
DNA mismatch repair protein Mlh1 (MutL protein homolog 1)
Gene: MLH1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.688

Property	Details
Experiments	28439008, 32814904, 16546997, 15225546
Identification Methods	pull down, far western blotting
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001673 - male germ cell nucleus GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006298 - mismatch repair and 1 others more... GO:0019899 - enzyme binding
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 261 Hs			1 756
+	Sc
		550545 PCNA_YEAST (1-259): 1.46e-99: 293: 35.52		MLH1_YEAST (4-756): 0: 732: 36.52
+	Hs
		517150 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		PMS2_HUMAN (5-558): 4e-143: 443: 23.12
+	Hs
		517526 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		MLH3_HUMAN (7-509): 3.9e-109: 364: 22.73
+	Sc
		536211 PCNA_YEAST (1-259): 1.46e-99: 293: 35.52		PMS1_YEAST (7-530): 2.45e-136: 425: 22.97
+	Sc
		550582 PCNA_YEAST (1-259): 1.46e-99: 293: 35.52		MLH3_YEAST (4-347): 2.98e-91: 302: 22.74