HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: TENS2 (Q63HR2)
Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase)
Gene: TNS2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	22973453, 16273093
Identification Methods	pull down, unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C1_1~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1342 Hs			1 1409
+	Hs
		601935 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		TENS3_HUMAN (125-1409): 1.7e-168: 545: 33.49
+	Hs
		1070974 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		TENS2_HUMAN (1-1409): 0: 748: 100.00
+	Hs
		383851 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		TENS2_HUMAN (1-1409): 0: 748: 100.00
+	Hs
		601866 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		PTEN_HUMAN (118-478): 6.4e-114: 365: 24.37
+	Hs
		601863 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		TPTE_HUMAN (107-424): 3.97e-104: 344: 25.15
+	Hs
		1070975 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		TENS3_HUMAN (125-1409): 1.7e-168: 545: 33.49
+	Rn
		94037 Q9QX70_RAT (24-1145): 0: 1054: 43.41		F1LN91_RAT (31-1409): 0: 604: 33.49
+	Hs
		383853 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		TENS3_HUMAN (125-1409): 1.7e-168: 545: 33.49
+	Hs
		601945 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		TENS4_HUMAN (847-1409): 1.5e-44: 175: 32.50
+	Hs
		554266 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		MUC1_HUMAN (747-1330): 8.52e-25: 114: 12.10
+	Hs
		602002 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		TENS1_HUMAN (427-1338): 2.81e-12: 74: 11.34
+	Hs
		338213 EGFR_HUMAN (18-1157): 0: 1041: 42.30		PTEN_HUMAN (118-478): 6.4e-114: 365: 24.37
+	Hs
		1070981 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		TENS4_HUMAN (847-1409): 1.5e-44: 175: 32.50
+	Hs
		554307 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		MUC1_HUMAN (747-1330): 8.52e-25: 114: 12.10
+	Hs
		1071015 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		TENS1_HUMAN (427-1338): 2.81e-12: 74: 11.34
+	Hs
		383583 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		MUC1_HUMAN (747-1330): 8.52e-25: 114: 12.10
+	Hs
		337875 EGFR_HUMAN (18-1157): 0: 1041: 42.30		MUC1_HUMAN (747-1330): 8.52e-25: 114: 12.10
+	Mm
		964562 EGFR_MOUSE (20-1145): 0: 1071: 43.44		ASPP1_MOUSE (648-1087): 3.63e-14: 80: 16.78
+	Hs
		383987 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		TENS1_HUMAN (427-1338): 2.81e-12: 74: 11.34
+	Hs
		383936 ERBB2_HUMAN (25-1222): 0: 1067: 39.95		ASPP1_HUMAN (749-1169): 6.23e-10: 66.1: 12.59