HitPredict

Interactor 1: PCNA (P12004)
Proliferating cell nuclear antigen (PCNA) (Cyclin)
Gene: PCNA

Interactor 2: UHRF1 (Q96T88)
E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)
Gene: UHRF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.825

Property	Details
Experiments	26496610, 30357346
Identification Methods	affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PCNA_C~ubiquitin
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005657 - replication fork
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 261 Hs			1 793
+	Hs
		517414 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		UHRF2_HUMAN (1-793): 0: 774: 53.01
+	Dm
		332856 PCNA2_DROME (1-259): 3.01e-106: 309: 47.88		CHDM_DROME (105-627): 2.35e-62: 230: 12.22
+	Hs
		517254 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		TRI25_HUMAN (715-786): 9.14e-20: 96.1: 31.08
+	At
		1258482 PCNA1_ARATH (1-261): 8.59e-119: 342: 64.75		ATXR5_ARATH (278-414): 1.32e-20: 96.5: 19.74
+	At
		1324730 PCNA1_ARATH (1-261): 8.59e-119: 342: 64.75		ATXR6_ARATH (292-416): 2.87e-18: 89.1: 26.32