HitPredict

Interactor 1: TPR (P12270)
Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein)
Gene: TPR

Interactor 2: MCM2 (P49736)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)
Gene: MCM2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25963833
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2363 Hs			1 904
+	Hs
		522541 MYH1_HUMAN (1204-2274): 3.68e-38: 160: 10.14		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		832772 MYH2_HUMAN (1310-2333): 1.22e-33: 145: 10.75		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		528403 MYH8_HUMAN (1310-2333): 3.23e-33: 144: 10.47		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		528364 MYH6_HUMAN (1310-2320): 5.95e-32: 139: 10.02		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		724713 MYH9_HUMAN (1404-2309): 4.5e-28: 127: 9.29		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		832810 MYH4_HUMAN (1417-2325): 2.22e-27: 124: 8.16		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		832468 NUMA1_HUMAN (1475-2060): 2.53e-11: 72: 10.08		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		551638 DESP_HUMAN (688-1584): 5.95e-11: 70.5: 18.36		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		709034 CP250_HUMAN (190-2334): 9.64e-69: 260: 10.18		MCM7_HUMAN (188-886): 0: 707: 27.35
+	Hs
		708443 NUMA1_HUMAN (1475-2060): 2.53e-11: 72: 10.08		MCM4_HUMAN (2-885): 0: 847: 28.42
+	Hs
		166673 CE290_HUMAN (3-2065): 8.45e-54: 211: 10.70		MCM7_HUMAN (188-886): 0: 707: 27.35
+	Hs
		148446 CTRO_HUMAN (1173-1646): 8.14e-09: 63.5: 22.34		MCM4_HUMAN (2-885): 0: 847: 28.42
+	Hs
		708563 MYH9_HUMAN (1404-2309): 4.5e-28: 127: 9.29		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Sc
		675550 MLP1_YEAST (803-2121): 2.34e-26: 121: 8.26		MCM4_YEAST (7-889): 0: 764: 25.82
+	Hs
		551620 DESP_HUMAN (688-1584): 5.95e-11: 70.5: 18.36		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		148447 CTRO_HUMAN (1173-1646): 8.14e-09: 63.5: 22.34		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		627267 NUMA1_HUMAN (1475-2060): 2.53e-11: 72: 10.08		MCM3_HUMAN (186-897): 0: 725: 29.20
+	Hs
		148412 CTRO_HUMAN (1173-1646): 8.14e-09: 63.5: 22.34		MCM3_HUMAN (186-897): 0: 725: 29.20
+	Hs
		1055556 NUMA1_HUMAN (1475-2060): 2.53e-11: 72: 10.08		MCM6_HUMAN (186-817): 0: 710: 31.18
+	Hs
		708910 NUMA1_HUMAN (1475-2060): 2.53e-11: 72: 10.08		MCM7_HUMAN (188-886): 0: 707: 27.35