HitPredict

Interactor 1: PSA1 (P12881)
Proteasome subunit alpha type-1 (PROS-Dm35) (Proteasome 35 kDa subunit)
Gene: Prosalpha6

Interactor 2: PRS4 (P48601)
26S proteasome regulatory subunit 4 (P26s4)
Gene: Rpt2

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.743

Property	Details
Experiments	22036573, 19079254
Identification Methods	affinity chromatography technology, two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AAA~Proteasome, AAA_lid_3~Proteasome, AAA~Proteasome_A_N, AAA_lid_3~Proteasome_A_N
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 279 Dm			1 439
+	At
		286455 PSA6B_ARATH (6-243): 1.14e-105: 308: 32.92		PRS4A_ARATH (1-439): 4.1e-137: 402: 77.43
+	Dm
		611634 PSA71_DROME (4-236): 4.09e-102: 299: 30.93		PRS4_DROME (1-439): 7.01e-141: 411: 100.00
+	Hs
		637380 PSA1_HUMAN (1-269): 8.96e-103: 302: 52.42		PRS4_HUMAN (24-439): 8.92e-138: 404: 92.55
+	Dm
		820516 Q9VK14_DROME (1-268): 1.62e-99: 294: 58.48		PRS4_DROME (1-439): 7.01e-141: 411: 100.00
+	At
		189237 PSA7B_ARATH (5-236): 1.08e-101: 298: 36.71		PRS4A_ARATH (1-439): 4.1e-137: 402: 77.43
+	Dm
		186097 PSA1_DROME (1-279): 9.24e-111: 322: 100.00		PRS8_DROME (60-438): 2.22e-125: 371: 45.71
+	Dm
		522527 PSA1_DROME (1-279): 9.24e-111: 322: 100.00		Q9W414_DROME (50-433): 9.11e-123: 364: 41.93
+	Dm
		522506 PSA1_DROME (1-279): 9.24e-111: 322: 100.00		Q9V405_DROME (36-432): 2.02e-122: 363: 47.61
+	At
		286460 PSA5A_ARATH (1-239): 3.86e-95: 281: 33.20		PRS4A_ARATH (1-439): 4.1e-137: 402: 77.43
+	Dm
		186099 PSA71_DROME (4-236): 4.09e-102: 299: 30.93		PRS8_DROME (60-438): 2.22e-125: 371: 45.71
+	Dm
		1369057 Q9VK14_DROME (1-268): 1.62e-99: 294: 58.48		Q9VTQ9_DROME (49-433): 3.47e-127: 375: 41.30
+	Hs
		637341 PSA1_HUMAN (1-269): 8.96e-103: 302: 52.42		PRS7_HUMAN (8-439): 1.59e-123: 367: 37.16
+	Hs
		637383 PSA1_HUMAN (1-269): 8.96e-103: 302: 52.42		PRS10_HUMAN (49-433): 5.5e-124: 366: 40.26
+	Hs
		637381 PSA1_HUMAN (1-269): 8.96e-103: 302: 52.42		PRS8_HUMAN (43-438): 1.09e-122: 364: 44.28
+	Dm
		611676 PSA71_DROME (4-236): 4.09e-102: 299: 30.93		Q9W414_DROME (50-433): 9.11e-123: 364: 41.93
+	Hs
		637354 PSA1_HUMAN (1-269): 8.96e-103: 302: 52.42		PRS6B_HUMAN (49-432): 2.56e-121: 361: 48.18
+	Dm
		611655 PSA71_DROME (4-236): 4.09e-102: 299: 30.93		Q9V405_DROME (36-432): 2.02e-122: 363: 47.61
+	Dm
		522505 PSA1_DROME (1-279): 9.24e-111: 322: 100.00		Q9V3V6_DROME (72-430): 1.53e-112: 338: 46.97
+	Hs
		656158 PSA5_HUMAN (1-239): 7.88e-95: 280: 30.08		PRS7_HUMAN (8-439): 1.59e-123: 367: 37.16
+	Dm
		611654 PSA71_DROME (4-236): 4.09e-102: 299: 30.93		Q9V3V6_DROME (72-430): 1.53e-112: 338: 46.97