Protein: ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (EC 2.3.1.168) (52 kDa mitochondrial autoantigen of primary biliary cirrhosis) (Branched chain 2-oxo-acid dehydrogenase complex component E2) (BCOADC-E2) (Branched-chain alpha-keto acid dehydrogenase complex component E2) (BCKAD-E2) (BCKADE2) (BCKDH-E2) (Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex) (Dihydrolipoamide branched chain transacylase) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase)

Gene: ODB2, DBT
Organism: Homo sapiens
Interactions: 199
UniProt ID: P11182

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0005829 - cytosol
GO:0009083 - branched-chain amino acid catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

484346

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

3

16

High-throughput

0.861

High

539290

ODBB
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

2

8

High-throughput

0.811

High

539365

PPM1K
Protein phosphatase Mn(2+)-dependent 1K

6

0

High-throughput

0.701

High

539417

ACAD9
Complex I assembly factor ACAD9, mitochondrial

4

3

High-throughput

0.699

High

539382

RRFM
Ribosome-recycling factor, mitochondrial

4

3

High-throughput

0.694

High

229405

IDH3B
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

3

1

High-throughput

0.667

High

539292

ECHM
Enoyl-CoA hydratase, mitochondrial

3

6

High-throughput

0.667

High

539345

MRM1
rRNA methyltransferase 1, mitochondrial

3

2

High-throughput

0.667

High

539387

FAH2A
Oxaloacetate tautomerase FAHD2A, mitochondrial

3

3

High-throughput

0.667

High

539432

HDAC6
Protein deacetylase HDAC6

3

3

Small-scale

0.667

High

539286

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

3

2

High-throughput

0.662

High

539367

PTGR3
Prostaglandin reductase 3

3

4

High-throughput

0.662

High

539399

TR61B
tRNA

3

2

High-throughput

0.662

High

539371

GRPE2
GrpE protein homolog 2, mitochondrial

4

0

High-throughput

0.661

High

539443

LIPT
Lipoyl amidotransferase LIPT1, mitochondrial

3

0

High-throughput

0.638

High

539285

RALB
Ras-related protein Ral-B

2

6

High-throughput

0.628

High

539317

RT11
Small ribosomal subunit protein uS11m

2

3

High-throughput

0.628

High

539435

NOCT
Nocturnin

2

1

High-throughput

0.628

High

539289

TNR1B
Tumor necrosis factor receptor superfamily member 1B

3

0

High-throughput

0.622

High

348335

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

17

High-throughput

0.618

High

470824

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

14

High-throughput

0.618

High

287229

RF1M
Peptide chain release factor 1, mitochondrial

2

10

High-throughput

0.611

High

539400

HINT2
Adenosine 5'-monophosphoramidase HINT2

2

3

High-throughput

0.611

High

539407

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

2

4

High-throughput

0.611

High

539337

CDO1
Cysteine dioxygenase type 1

2

0

High-throughput

0.602

High

539340

THEM4
Acyl-coenzyme A thioesterase THEM4

2

0

High-throughput

0.602

High

539370

PPTC7
Protein phosphatase PTC7 homolog

2

0

High-throughput

0.602

High

539295

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

2

1

High-throughput

0.601

High

539385

MMAB
Corrinoid adenosyltransferase MMAB

2

1

High-throughput

0.601

High

539444

CAH5B
Carbonic anhydrase 5B, mitochondrial

2

0

High-throughput

0.595

High

279629

CISY
Citrate synthase, mitochondrial

2

3

High-throughput

0.584

High

539305

PPT1
Palmitoyl-protein thioesterase 1

2

1

Small-scale

0.584

High

528409

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

2

0

High-throughput

0.576

High

539389

MCEE
Methylmalonyl-CoA epimerase, mitochondrial

2

0

High-throughput

0.576

High

539372

DCA11
DDB1- and CUL4-associated factor 11

2

3

High-throughput

0.574

High

539331

ICT1
Large ribosomal subunit protein mL62

2

2

High-throughput

0.571

High

143537

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

3

High-throughput

0.536

High

488093

IFIT2
Interferon-induced protein with tetratricopeptide repeats 2

1

3

High-throughput

0.536

High

539299

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

3

High-throughput

0.536

High

539308

RBM5
RNA-binding protein 5

1

2

High-throughput

0.536

High

539316

KGD4
Alpha-ketoglutarate dehydrogenase component 4

1

2

High-throughput

0.536

High

539326

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

6

High-throughput

0.536

High

539347

FAH2B
Oxaloacetate tautomerase FAHD2B, mitochondrial

1

3

High-throughput

0.536

High

539349

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

3

High-throughput

0.536

High

539361

MICU3
Calcium uptake protein 3, mitochondrial

1

2

High-throughput

0.536

High

539362

HOGA1
4-hydroxy-2-oxoglutarate aldolase, mitochondrial

1

1

High-throughput

0.536

High

539363

ECHD2
Enoyl-CoA hydratase domain-containing protein 2, mitochondrial

1

6

High-throughput

0.536

High

539364

FABD
Malonyl-CoA-acyl carrier protein transacylase, mitochondrial

1

1

High-throughput

0.536

High

539392

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

2

High-throughput

0.536

High

539398

MECR
Enoyl-[acyl-carrier-protein] reductase, mitochondrial

1

4

High-throughput

0.536

High

539402

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

3

High-throughput

0.536

High

539410

PHS2
Pterin-4-alpha-carbinolamine dehydratase 2

1

1

High-throughput

0.536

High

539419

AGO3
Protein argonaute-3

1

4

High-throughput

0.536

High

539420

AGO4
Protein argonaute-4

1

4

High-throughput

0.536

High

539421

E41L5
Band 4.1-like protein 5

1

3

High-throughput

0.536

High

539430

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

1

High-throughput

0.536

High

539448

UBP16
Ubiquitin carboxyl-terminal hydrolase 16

1

4

High-throughput

0.536

High

539438

HECD1
E3 ubiquitin-protein ligase HECTD1

2

7

High-throughput

0.533

High

539321

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

5

High-throughput

0.515

High

539374

DDX1
ATP-dependent RNA helicase DDX1

1

1

High-throughput

0.515

High

278616

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

1

0

High-throughput

0.513

High

539309

NUDT6
Nucleoside diphosphate-linked moiety X motif 6

1

0

High-throughput

0.513

High

539318

RT06
Small ribosomal subunit protein bS6m

1

0

High-throughput

0.513

High

539338

OXLD1
Oxidoreductase-like domain-containing protein 1

1

0

High-throughput

0.513

High

539359

ISCA2
Iron-sulfur cluster assembly 2 homolog, mitochondrial

1

0

High-throughput

0.513

High

539384

RM53
Large ribosomal subunit protein mL53

1

0

High-throughput

0.513

High

539393

NPS3B
Protein NipSnap homolog 3B

1

0

High-throughput

0.513

High

539394

GDAH
Guanidino acid hydrolase, mitochondrial

1

0

High-throughput

0.513

High

539412

RM18
Large ribosomal subunit protein uL18m

1

0

High-throughput

0.513

High

539418

PAAT
ATPase PAAT

1

0

High-throughput

0.513

High

539424

ACO13
Acyl-coenzyme A thioesterase 13

1

0

High-throughput

0.513

High

539446

MSRB2
Methionine-R-sulfoxide reductase B2, mitochondrial

1

0

High-throughput

0.513

High

539447

RT18C
Small ribosomal subunit protein bS18m

1

0

High-throughput

0.513

High

185385

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

5

High-throughput

0.501

High

464238

FUMH
Fumarate hydratase, mitochondrial

1

0

High-throughput

0.493

High

539304

GATM
Glycine amidinotransferase, mitochondrial

1

0

High-throughput

0.493

High

539397

MTND
Acireductone dioxygenase

1

0

High-throughput

0.493

High

290432

SURF6
Surfeit locus protein 6

1

1

High-throughput

0.489

High

539353

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

1

3

High-throughput

0.489

High

539368

F133A
Protein FAM133A

1

1

High-throughput

0.489

High

539411

RAB17
Ras-related protein Rab-17

1

8

High-throughput

0.489

High

66120

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

2

High-throughput

0.479

High

135038

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

1

High-throughput

0.479

High

156589

DC1I1
Cytoplasmic dynein 1 intermediate chain 1

1

6

High-throughput

0.479

High

240587

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

281865

MPPB
Mitochondrial-processing peptidase subunit beta

1

10

High-throughput

0.479

High

315054

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.479

High

324086

CE152
Centrosomal protein of 152 kDa

1

4

High-throughput

0.479

High

348949

LATS1
Serine/threonine-protein kinase LATS1

1

4

High-throughput

0.479

High

350774

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

5

High-throughput

0.479

High

371021

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

403782

GCR
Glucocorticoid receptor

1

7

Small-scale

0.479

High

519034

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

1

High-throughput

0.479

High

539291

SP100
Nuclear autoantigen Sp-100

1

8

High-throughput

0.479

High

539294

MERL
Merlin

1

3

High-throughput

0.479

High

539296

MDHM
Malate dehydrogenase, mitochondrial

1

4

High-throughput

0.479

High

539298

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

2

High-throughput

0.479

High

539300

EFTS
Elongation factor Ts, mitochondrial

1

3

High-throughput

0.479

High

539301

IF2M
Translation initiation factor IF-2, mitochondrial

1

9

High-throughput

0.479

High

539303

EFTU
Elongation factor Tu, mitochondrial

1

6

High-throughput

0.479

High

539306

MECP2
Methyl-CpG-binding protein 2

1

3

High-throughput

0.479

High

539307

RND2
Rho-related GTP-binding protein RhoN

1

14

High-throughput

0.479

High

539310

ATX3
Ataxin-3

1

1

High-throughput

0.479

High

539312

DJB13
DnaJ homolog subfamily B member 13

1

3

High-throughput

0.479

High

539313

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

Small-scale

0.479

High

539314

DYLT1
Dynein light chain Tctex-type 1

1

2

High-throughput

0.479

High

539319

RHOG
Rho-related GTP-binding protein RhoG

1

6

High-throughput

0.479

High

539320

TFAM
Transcription factor A, mitochondrial

1

6

High-throughput

0.479

High

539322

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

2

High-throughput

0.479

High

539323

MPPA
Mitochondrial-processing peptidase subunit alpha

1

10

High-throughput

0.479

High

539324

GRSF1
G-rich sequence factor 1

1

4

High-throughput

0.479

High

539325

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

3

High-throughput

0.479

High

539328

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

539329

CUL3
Cullin-3

1

1

High-throughput

0.479

High

539330

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

6

High-throughput

0.479

High

539332

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

9

High-throughput

0.479

High

539333

EMC2
ER membrane protein complex subunit 2

1

3

High-throughput

0.479

High

539335

RHOH
Rho-related GTP-binding protein RhoH

1

11

High-throughput

0.479

High

539336

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

3

High-throughput

0.479

High

539339

SYAM
Alanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

539343

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.479

High

539344

FTM
Protein fantom

1

8

High-throughput

0.479

High

539346

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

6

High-throughput

0.479

High

539351

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

539354

RHOU
Rho-related GTP-binding protein RhoU

1

11

High-throughput

0.479

High

539355

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

9

High-throughput

0.479

High

539356

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

5

High-throughput

0.479

High

539357

CNTRL
Centriolin

1

8

High-throughput

0.479

High

539376

ESR2
Estrogen receptor beta

1

7

High-throughput

0.479

High

539378

REQU
Zinc finger protein ubi-d4

1

3

High-throughput

0.479

High

539379

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

8

High-throughput

0.479

High

539380

FAKD4
FAST kinase domain-containing protein 4

1

9

High-throughput

0.479

High

539381

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

6

High-throughput

0.479

High

539383

MTEF3
Transcription termination factor 3, mitochondrial

1

1

High-throughput

0.479

High

539386

BICD1
Protein bicaudal D homolog 1

1

7

High-throughput

0.479

High

539390

EFGM
Elongation factor G, mitochondrial

1

8

High-throughput

0.479

High

539395

TACO1
Translational activator of cytochrome c oxidase 1

1

3

High-throughput

0.479

High

539396

CQ080
Mitochondrial nucleoid-associated protein 1

1

3

High-throughput

0.479

High

539403

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

3

Small-scale

0.479

High

539404

RT26
Small ribosomal subunit protein mS26

1

3

High-throughput

0.479

High

539405

KPCD2
Serine/threonine-protein kinase D2

1

1

High-throughput

0.479

High

539408

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

3

High-throughput

0.479

High

539413

IF3M
Translation initiation factor IF-3, mitochondrial

1

2

High-throughput

0.479

High

539414

MTRFR
Mitochondrial translation release factor in rescue

1

10

High-throughput

0.479

High

539415

MTG2
Mitochondrial ribosome-associated GTPase 2

1

6

High-throughput

0.479

High

539416

MET17
Ribosome assembly protein METTL17, mitochondrial

1

4

High-throughput

0.479

High

539423

BRD7
Bromodomain-containing protein 7

1

7

High-throughput

0.479

High

539426

ANLN
Anillin

1

2

High-throughput

0.479

High

539427

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

2

High-throughput

0.479

High

539428

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

4

High-throughput

0.479

High

539431

MRES1
Mitochondrial transcription rescue factor 1

1

3

High-throughput

0.479

High

539433

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

10

High-throughput

0.479

High

539434

HOOK1
Protein Hook homolog 1

1

5

High-throughput

0.479

High

539437

BRPF3
Bromodomain and PHD finger-containing protein 3

1

8

High-throughput

0.479

High

539439

MYO6
Unconventional myosin-VI

1

4

High-throughput

0.479

High

539441

CE164
Centrosomal protein of 164 kDa

1

5

High-throughput

0.479

High

539445

RM11
Large ribosomal subunit protein uL11m

1

3

High-throughput

0.479

High

184260

NPHP1
Nephrocystin-1

1

0

High-throughput

0.458

High

539327

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

Small-scale

0.458

High

539334

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.458

High

539358

SLN11
Schlafen family member 11

1

0

Small-scale

0.458

High

539375

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.458

High

539422

DLRB1
Dynein light chain roadblock-type 1

1

0

High-throughput

0.458

High

539429

MKS1
Tectonic-like complex member MKS1

1

0

High-throughput

0.458

High

135462

DNM1L
Dynamin-1-like protein

1

1

Small-scale

0.445

High

226929

LIAS
Lipoyl synthase, mitochondrial

1

1

High-throughput

0.445

High

429197

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

442860

PRGR
Progesterone receptor

1

7

Small-scale

0.445

High

539293

BMI1
Polycomb complex protein BMI-1

1

3

High-throughput

0.445

High

539315

YBOX1
Y-box-binding protein 1

1

1

Small-scale

0.445

High

539341

CP135
Centrosomal protein of 135 kDa

1

9

High-throughput

0.445

High

539350

SYDM
Aspartate--tRNA ligase, mitochondrial

1

2

High-throughput

0.445

High

539369

POC5
Centrosomal protein POC5

1

3

High-throughput

0.445

High

539388

CEP63
Centrosomal protein of 63 kDa

1

7

High-throughput

0.445

High

539391

CK5P2
CDK5 regulatory subunit-associated protein 2

1

10

High-throughput

0.445

High

539449

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

5

High-throughput

0.445

High

342094

BRD1
Bromodomain-containing protein 1

1

5

High-throughput

0.437

High

472422

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

2

High-throughput

0.437

High

539287

TAL1
T-cell acute lymphocytic leukemia protein 1

1

2

High-throughput

0.437

High

539352

CE128
Centrosomal protein of 128 kDa

1

8

High-throughput

0.437

High

539366

NIN
Ninein

1

9

High-throughput

0.437

High

539373

PHIP
PH-interacting protein

1

5

High-throughput

0.437

High

539377

DPF3
Zinc finger protein DPF3

1

3

Small-scale

0.437

High

539401

CECR2
Chromatin remodeling regulator CECR2

1

7

High-throughput

0.437

High

539406

FOXQ1
Forkhead box protein Q1

1

3

High-throughput

0.437

High

539440

TRI33
E3 ubiquitin-protein ligase TRIM33

1

4

High-throughput

0.437

High

539442

SRRM2
Serine/arginine repetitive matrix protein 2

1

3

High-throughput

0.437

High

539288

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

0

High-throughput

0.426

High

539360

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

0

High-throughput

0.426

High

539297

CNDD3
Condensin-2 complex subunit D3

1

3

High-throughput

0.407

High

60635

CI170
Uncharacterized protein encoded by LINC02872

1

0

High-throughput

0.279

Low

539436

PRDM4
PR domain zinc finger protein 4

1

0

High-throughput

0.279

Low

539302

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

539311

KLF3
Krueppel-like factor 3

1

0

High-throughput

0.249

Low

539342

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

539348

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.249

Low

539409

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

539425

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.249

Low

219429

S26A4
Pendrin

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025