HitPredict

Interactor 1: PSA1 (P12881)
Proteasome subunit alpha type-1 (PROS-Dm35) (Proteasome 35 kDa subunit)
Gene: Prosalpha6

Interactor 2: Q7K148 (Q7K148)
Proteasome subunit beta
Gene: Prosbeta5

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.913

Property	Details
Experiments	23738891, 23457214, 25294943, 22036573, 19079254
Identification Methods	affinity chromatography technology, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Proteasome~Proteasome, Proteasome~Proteasome_A_N
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 279 Dm			1 282
+	Hs
		637323 PSA1_HUMAN (1-269): 8.96e-103: 302: 52.42		PSB8_HUMAN (1-277): 9.51e-104: 305: 48.74
+	Dm
		522498 PSA1_DROME (1-279): 9.24e-111: 322: 100.00		Q8T8V8_DROME (1-282): 2.17e-93: 280: 59.01
+	Dm
		522499 PSA1_DROME (1-279): 9.24e-111: 322: 100.00		PSA5_DROME (41-273): 2.51e-87: 262: 17.55
+	Hs
		637328 PSA1_HUMAN (1-269): 8.96e-103: 302: 52.42		PSB5_HUMAN (1-273): 8.79e-89: 266: 52.38
+	Hs
		637325 PSA1_HUMAN (1-269): 8.96e-103: 302: 52.42		PSA5_HUMAN (41-272): 1.3e-88: 265: 18.60
+	Ss
		94704 F2Z5L7_PIG (1-269): 8.96e-103: 302: 52.42		F2Z5K2_PIG (41-272): 1.3e-88: 265: 18.60
+	At
		286453 PSA6B_ARATH (6-243): 1.14e-105: 308: 32.92		PSB7B_ARATH (41-262): 4.59e-85: 257: 27.75
+	At
		188701 PSA6B_ARATH (6-243): 1.14e-105: 308: 32.92		PSB7A_ARATH (41-262): 1.15e-84: 256: 27.75
+	Dm
		522528 PSA1_DROME (1-279): 9.24e-111: 322: 100.00		Q9W470_DROME (47-267): 2.25e-78: 241: 28.51
+	Ss
		94582 F2Z5L7_PIG (1-269): 8.96e-103: 302: 52.42		F1SBA5_PIG (43-266): 9.31e-87: 260: 17.67
+	Hs
		156223 PSA1_HUMAN (1-269): 8.96e-103: 302: 52.42		PSA7_HUMAN (46-269): 2.53e-85: 257: 15.95
+	Hs
		637318 PSA1_HUMAN (1-269): 8.96e-103: 302: 52.42		PSA4_HUMAN (43-269): 9.16e-85: 256: 17.30
+	Dm
		522522 PSA1_DROME (1-279): 9.24e-111: 322: 100.00		Q9VUJ1_DROME (47-267): 1.41e-75: 233: 27.60
+	Hs
		637346 PSA1_HUMAN (1-269): 8.96e-103: 302: 52.42		PSB10_HUMAN (47-256): 3.95e-83: 252: 29.05
+	Hs
		637527 PSA1_HUMAN (1-269): 8.96e-103: 302: 52.42		PSB7_HUMAN (39-265): 6.52e-77: 236: 28.63
+	Hs
		637494 PSA1_HUMAN (1-269): 8.96e-103: 302: 52.42		PSMA8_HUMAN (43-269): 1.37e-75: 232: 17.08
+	Hs
		637327 PSA1_HUMAN (1-269): 8.96e-103: 302: 52.42		PSB6_HUMAN (69-259): 3.57e-73: 225: 30.21
+	Ss
		94705 F2Z5L7_PIG (1-269): 8.96e-103: 302: 52.42		G3DRF8_PIG (69-259): 2.34e-72: 224: 30.21
+	Dm
		47594 PSA1_DROME (1-279): 9.24e-111: 322: 100.00		A0AQH0_DROME (73-256): 1.52e-18: 84: 29.57
+	Hs
		637324 PSA1_HUMAN (1-269): 8.96e-103: 302: 52.42		PSB9_HUMAN (73-256): 2.23e-19: 85.9: 30.98