HitPredict

Interactor 1: SRC (P12931)
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Gene: SRC

Interactor 2: TNR1A (P19438)
Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)]
Gene: TNFRSF1A

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	15707590, 18606683, 9237663
Identification Methods	affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0045121 - membrane raft
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 536 Hs			1 455
+	Hs
		154294 FYN_HUMAN (1-536): 0: 598: 68.39		TR10B_HUMAN (31-445): 1.86e-78: 252: 19.81
+	Hs
		522788 SRC_HUMAN (1-536): 0: 651: 100.00		TNR6_HUMAN (1-167): 7.65e-47: 166: 23.21
+	Hs
		433256 YES_HUMAN (1-536): 0: 604: 73.85		TNR6_HUMAN (1-167): 7.65e-47: 166: 23.21
+	Hs
		412024 FYN_HUMAN (1-536): 0: 598: 68.39		TNR6_HUMAN (1-167): 7.65e-47: 166: 23.21
+	Mm
		192581 LYN_MOUSE (1-531): 0: 535: 52.26		TNR11_MOUSE (43-368): 3.3e-58: 203: 16.48
+	Hs
		411601 LCK_HUMAN (75-534): 0: 552: 58.48		TNR6_HUMAN (1-167): 7.65e-47: 166: 23.21
+	Mm
		591446 FYN_MOUSE (1-536): 0: 597: 68.58		TNR9_MOUSE (59-227): 3.58e-22: 97.4: 18.34
+	Mm
		411916 LCK_MOUSE (50-534): 0: 554: 56.17		TNR9_MOUSE (59-227): 3.58e-22: 97.4: 18.34
+	Mm
		648950 BTK_MOUSE (44-527): 7.13e-156: 461: 34.08		TNR5_MOUSE (43-326): 7e-52: 178: 20.63
+	Hs
		632254 BTK_HUMAN (43-527): 1.18e-154: 458: 34.35		TNR6_HUMAN (1-167): 7.65e-47: 166: 23.21