Protein: PTPRU
Receptor-type tyrosine-protein phosphatase U (R-PTP-U) (EC 3.1.3.48) (Pancreatic carcinoma phosphatase 2) (PCP-2) (Protein-tyrosine phosphatase J) (PTP-J) (hPTP-J) (Protein-tyrosine phosphatase pi) (PTP pi) (Protein-tyrosine phosphatase receptor omicron) (PTP-RO) (Receptor-type protein-tyrosine phosphatase psi) (R-PTP-psi)

Gene: PTPRU
Organism: Homo sapiens
Interactions: 118
UniProt ID: Q92729

Gene Ontology (top 5):
GO:0004725 - protein tyrosine phosphatase activity
GO:0005001 - transmembrane receptor protein tyrosine phosphatase activity
GO:0005886 - plasma membrane
GO:0005911 - cell-cell junction
GO:0006470 - protein dephosphorylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1144645

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

3

18

High-throughput

0.855

High

1116769

AAMP
Angio-associated migratory cell protein

4

0

High-throughput

0.846

High

1366845

CLC2D
C-type lectin domain family 2 member D

2

8

High-throughput

0.811

High

1366825

PTPRU
Receptor-type tyrosine-protein phosphatase U

1

17

Small-scale

0.699

High

410977

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.698

High

380327

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

3

High-throughput

0.691

High

596512

CTLA4
Cytotoxic T-lymphocyte protein 4

1

2

High-throughput

0.691

High

607402

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

4

High-throughput

0.691

High

688603

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

7

High-throughput

0.691

High

935775

MFAP4
Microfibril-associated glycoprotein 4

1

4

High-throughput

0.691

High

1030200

IL5RA
Interleukin-5 receptor subunit alpha

1

20

High-throughput

0.691

High

1180945

HFE
Hereditary hemochromatosis protein

1

6

High-throughput

0.691

High

1366834

SIRPD
Signal-regulatory protein delta

1

1

High-throughput

0.691

High

1366846

BTNL2
Butyrophilin-like protein 2

1

9

High-throughput

0.691

High

1159218

SGCA
Alpha-sarcoglycan

3

2

High-throughput

0.667

High

168438

NCTR3
Natural cytotoxicity triggering receptor 3

1

0

High-throughput

0.656

High

764929

CTNB1
Catenin beta-1

3

20

Small-scale

0.650

High

363660

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.647

High

136532

GOLI4
Golgi integral membrane protein 4

4

3

High-throughput

0.630

High

749797

CADH5
Cadherin-5

2

20

High-throughput

0.628

High

1366857

PCDGD
Protocadherin gamma-B1

2

18

High-throughput

0.628

High

567937

PRG2
Bone marrow proteoglycan

1

3

High-throughput

0.618

High

1177854

CL12B
C-type lectin domain family 12 member B

1

5

High-throughput

0.618

High

532096

KIT
Mast/stem cell growth factor receptor Kit

1

16

Small-scale

0.618

High

936404

AFAD
Afadin

1

10

High-throughput

0.618

High

170905

CLGN
Calmegin

3

8

High-throughput

0.593

High

1366852

TMM98
Transmembrane protein 98

2

0

High-throughput

0.576

High

1359341

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

2

6

High-throughput

0.574

High

1366830

TAFA4
Chemokine-like protein TAFA-4

2

1

High-throughput

0.574

High

1131341

GANAB
Neutral alpha-glucosidase AB

1

4

High-throughput

0.553

High

64374

CDHR4
Cadherin-related family member 4

1

20

High-throughput

0.536

High

1308274

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

1

High-throughput

0.536

High

1330123

PCD20
Protocadherin-20

1

19

High-throughput

0.536

High

1366847

FBX2
F-box only protein 2

1

9

High-throughput

0.536

High

1366848

PCDGG
Protocadherin gamma-B4

1

18

High-throughput

0.536

High

1366854

PCDB7
Protocadherin beta-7

1

18

High-throughput

0.536

High

1366855

PCDB3
Protocadherin beta-3

1

18

High-throughput

0.536

High

1366856

PCDGM
Protocadherin gamma-C5

1

17

High-throughput

0.536

High

1327703

MACOI
Macoilin

2

1

High-throughput

0.533

High

1227183

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.514

High

1366826

T106A
Transmembrane protein 106A

1

0

High-throughput

0.513

High

1366829

ASIC4
Acid-sensing ion channel 4

1

0

High-throughput

0.513

High

659723

OMGP
Oligodendrocyte-myelin glycoprotein

1

6

Small-scale

0.501

High

772512

IRS1
Insulin receptor substrate 1

1

6

Small-scale

0.501

High

231056

VEGFD
Vascular endothelial growth factor D

1

2

High-throughput

0.489

High

327075

NXPH3
Neurexophilin-3

1

1

High-throughput

0.489

High

342634

LY86
Lymphocyte antigen 86

1

1

High-throughput

0.489

High

388731

C1QB
Complement C1q subcomponent subunit B

1

3

High-throughput

0.489

High

1315970

NRSN1
Neurensin-1

1

1

High-throughput

0.489

High

1325170

TAFA2
Chemokine-like protein TAFA-2

1

1

High-throughput

0.489

High

1362517

SIA8D
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

1

1

High-throughput

0.489

High

1366836

SDF2L
Stromal cell-derived factor 2-like protein 1

1

2

High-throughput

0.489

High

1366838

FBX6
F-box only protein 6

1

9

High-throughput

0.489

High

1366839

CAH10
Carbonic anhydrase-related protein 10

1

5

High-throughput

0.489

High

1366840

CBLN4
Cerebellin-4

1

2

High-throughput

0.489

High

1366843

DNJB9
DnaJ homolog subfamily B member 9

1

6

High-throughput

0.489

High

414325

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

764401

CTNA1
Catenin alpha-1

1

1

High-throughput

0.479

High

813181

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

1

High-throughput

0.479

High

875738

PRC2A
Protein PRRC2A

1

1

High-throughput

0.479

High

1092739

RHG05
Rho GTPase-activating protein 5

1

1

High-throughput

0.479

High

1119863

CKAP5
Cytoskeleton-associated protein 5

1

6

High-throughput

0.479

High

1120785

DSG2
Desmoglein-2

1

20

High-throughput

0.479

High

1142347

PDIA6
Protein disulfide-isomerase A6

1

13

High-throughput

0.479

High

1366827

ASTRA
Protein Aster-A

1

1

High-throughput

0.479

High

1366833

ACE2
Angiotensin-converting enzyme 2

1

2

Small-scale

0.479

High

783114

ARL2
ADP-ribosylation factor-like protein 2

1

5

High-throughput

0.470

High

255145

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

5

High-throughput

0.445

High

609766

LEG3
Galectin-3

1

20

High-throughput

0.445

High

877702

SL9A3
Sodium/hydrogen exchanger 3

1

1

High-throughput

0.445

High

1119231

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

7

High-throughput

0.445

High

1359474

CTL1
Choline transporter-like protein 1

1

1

High-throughput

0.445

High

128286

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

6

High-throughput

0.437

High

173158

XPO1
Exportin-1

1

14

High-throughput

0.437

High

452353

PDIA1
Protein disulfide-isomerase

1

13

High-throughput

0.437

High

566783

PDIA4
Protein disulfide-isomerase A4

1

13

High-throughput

0.437

High

697976

CALR
Calreticulin

1

8

High-throughput

0.437

High

698969

CALX
Calnexin

1

8

High-throughput

0.437

High

717563

PDIA3
Protein disulfide-isomerase A3

1

13

High-throughput

0.437

High

934128

XPO2
Exportin-2

1

14

High-throughput

0.437

High

934938

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.437

High

1008266

PRKDC
DNA-dependent protein kinase catalytic subunit

1

1

High-throughput

0.437

High

1038919

PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

1

3

High-throughput

0.437

High

1143649

NOMO1
BOS complex subunit NOMO1

1

2

High-throughput

0.437

High

1147549

UBE3C
Ubiquitin-protein ligase E3C

1

4

High-throughput

0.437

High

1178610

KIF7
Kinesin-like protein KIF7

1

2

High-throughput

0.437

High

1206507

PRC2B
Protein PRRC2B

1

1

High-throughput

0.437

High

1211402

NHSL1
NHS-like protein 1

1

6

High-throughput

0.437

High

1247749

NHS
Actin remodeling regulator NHS

1

3

High-throughput

0.437

High

1277508

MON2
Protein MON2 homolog

1

2

High-throughput

0.437

High

1312027

DJC10
DnaJ homolog subfamily C member 10

1

19

High-throughput

0.437

High

1352915

PO210
Nuclear pore membrane glycoprotein 210

1

2

High-throughput

0.437

High

1366831

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

4

High-throughput

0.437

High

1366832

FUT8
Alpha-(1,6)-fucosyltransferase

1

2

High-throughput

0.437

High

1366835

UN45A
Protein unc-45 homolog A

1

2

High-throughput

0.437

High

1366841

ABI2
Abl interactor 2

1

9

High-throughput

0.437

High

1366842

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

3

High-throughput

0.437

High

1366844

DJB11
DnaJ homolog subfamily B member 11

1

1

High-throughput

0.437

High

1366849

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

2

High-throughput

0.437

High

1366850

DJC16
DnaJ homolog subfamily C member 16

1

17

High-throughput

0.437

High

1366851

MAN1
Inner nuclear membrane protein Man1

1

1

High-throughput

0.437

High

244991

KATIP
Katanin-interacting protein

1

0

High-throughput

0.426

High

859930

RL28
Large ribosomal subunit protein eL28

1

2

High-throughput

0.407

High

943530

G6PT2
Glucose-6-phosphate exchanger SLC37A1

1

2

High-throughput

0.407

High

1242187

NPAL3
NIPA-like protein 3

1

4

High-throughput

0.407

High

1366828

SAAL1
Protein SAAL1

1

4

High-throughput

0.407

High

351717

SG1D1
Secretoglobin family 1D member 1

2

0

High-throughput

0.328

High

1271100

TM10C
tRNA methyltransferase 10 homolog C

2

0

High-throughput

0.298

High

224508

PI15
Peptidase inhibitor 15

1

0

High-throughput

0.279

Low

1293632

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.279

Low

1347283

FIBIN
Fin bud initiation factor homolog

1

0

High-throughput

0.279

Low

961472

OSTN
Osteocrin

1

0

Small-scale

0.261

Low

51641

CBAR1
CBY1-interacting BAR domain-containing protein 1

1

0

High-throughput

0.249

Low

245508

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

0

High-throughput

0.249

Low

693883

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.249

Low

1366837

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.249

Low

1366853

TELO2
Telomere length regulation protein TEL2 homolog

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025