HitPredict

Interactor 1: SRC (P12931)
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Gene: SRC

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.641

Property	Details
Experiments	11032808, 11013076, 12630920
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005739 - mitochondrion GO:0007165 - signal transduction GO:0019899 - enzyme binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 536 Hs			1 530
+	Hs
		368894 SRC_HUMAN (1-536): 0: 651: 100.00		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		433435 YES_HUMAN (1-536): 0: 604: 73.85		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Mm
		403414 SRC_MOUSE (1-536): 0: 650: 98.13		ESR1_MOUSE (9-529): 4.88e-134: 403: 43.72
+	Rn
		411266 SRC_RAT (1-536): 0: 644: 97.95		ESR1_RAT (9-529): 1.16e-129: 392: 43.29
+	Hs
		368834 YES_HUMAN (1-536): 0: 604: 73.85		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		522762 SRC_HUMAN (1-536): 0: 651: 100.00		RXRA_HUMAN (13-502): 1.6e-119: 361: 25.71
+	Hs
		377057 SRC_HUMAN (1-536): 0: 651: 100.00		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		487890 SRC_HUMAN (1-536): 0: 651: 100.00		RARA_HUMAN (52-505): 3.54e-105: 324: 23.74
+	Hs
		377007 FYN_HUMAN (1-536): 0: 598: 68.39		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		377006 LCK_HUMAN (75-534): 0: 552: 58.48		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		414427 SRC_HUMAN (1-536): 0: 651: 100.00		PRGR_HUMAN (149-459): 2.26e-41: 161: 32.82
+	Hs
		487088 SRC_HUMAN (1-536): 0: 651: 100.00		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		433225 YES_HUMAN (1-536): 0: 604: 73.85		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		454790 FGR_HUMAN (1-535): 0: 583: 65.99		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		442764 HCK_HUMAN (1-531): 0: 569: 55.22		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		411564 LCK_HUMAN (75-534): 0: 552: 58.48		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		433537 LYN_HUMAN (1-531): 0: 532: 52.44		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		487245 BLK_HUMAN (45-531): 1.62e-179: 516: 57.58		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		487203 ABL2_HUMAN (11-536): 3.03e-170: 514: 39.03		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		337320 ABL1_HUMAN (47-536): 5.59e-169: 509: 40.00		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59