Protein: P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha)

Gene: P3C2A, PIK3C2A
Organism: Homo sapiens
Interactions: 183
UniProt ID: O00443

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005802 - trans-Golgi network
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

135967

HAVR2
Hepatitis A virus cellular receptor 2

2

2

High-throughput

0.811

High

135889

1433B
14-3-3 protein beta/alpha

6

20

High-throughput

0.735

High

135861

STABP
STAM-binding protein

5

1

High-throughput

0.716

High

135926

PICAL
Phosphatidylinositol-binding clathrin assembly protein

3

3

High-throughput

0.675

High

135876

CLCB
Clathrin light chain B

3

3

High-throughput

0.667

High

135962

CCNJL
Cyclin-J-like protein

3

2

High-throughput

0.667

High

135931

EPN4
Clathrin interactor 1

3

1

High-throughput

0.662

High

135977

STALP
AMSH-like protease

3

1

High-throughput

0.662

High

135935

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

4

0

High-throughput

0.661

High

135946

SNPC4
snRNA-activating protein complex subunit 4

1

0

High-throughput

0.656

High

136004

ANLN
Anillin

1

0

High-throughput

0.656

High

136013

PILRA
Paired immunoglobulin-like type 2 receptor alpha

1

0

High-throughput

0.656

High

135911

1433G
14-3-3 protein gamma

2

20

High-throughput

0.635

High

135913

1433E
14-3-3 protein epsilon

2

6

High-throughput

0.635

High

135915

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.635

High

135921

1433F
14-3-3 protein eta

2

20

High-throughput

0.635

High

135923

CDC16
Cell division cycle protein 16 homolog

2

2

High-throughput

0.628

High

126354

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

135850

STX6
Syntaxin-6

1

2

High-throughput

0.618

High

135857

RHBT1
Rho-related BTB domain-containing protein 1

1

20

High-throughput

0.618

High

135869

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.618

High

135879

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

135903

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

135909

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

135910

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

135925

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

8

High-throughput

0.618

High

135948

A16L1
Autophagy-related protein 16-1

1

12

High-throughput

0.618

High

135956

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

135980

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.618

High

135985

DNJC7
DnaJ homolog subfamily C member 7

1

6

High-throughput

0.618

High

135997

PKHA4
Pleckstrin homology domain-containing family A member 4

1

14

High-throughput

0.618

High

136002

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

136003

MYO10
Unconventional myosin-X

1

7

Small-scale

0.618

High

136012

FBW1B
F-box/WD repeat-containing protein 11

1

6

High-throughput

0.618

High

47925

RBM47
RNA-binding protein 47

2

3

High-throughput

0.611

High

135875

CLCA
Clathrin light chain A

2

3

High-throughput

0.611

High

135996

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

2

2

Small-scale

0.611

High

135950

CNDH2
Condensin-2 complex subunit H2

2

0

High-throughput

0.602

High

135976

F136A
Protein FAM136A

2

0

High-throughput

0.602

High

136019

CRYL1
Lambda-crystallin homolog

2

0

High-throughput

0.602

High

135877

HSP7C
Heat shock cognate 71 kDa protein

2

1

High-throughput

0.584

High

135845

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

14

High-throughput

0.575

High

135951

PKHA7
Pleckstrin homology domain-containing family A member 7

1

10

High-throughput

0.575

High

135868

ESR1
Estrogen receptor

2

10

High-throughput

0.571

High

135900

PAXI
Paxillin

2

1

High-throughput

0.571

High

135886

1433T
14-3-3 protein theta

1

20

High-throughput

0.554

High

135942

AMOT
Angiomotin

1

8

High-throughput

0.541

High

135846

GAK
Cyclin-G-associated kinase

1

2

High-throughput

0.536

High

135847

SC16A
Protein transport protein Sec16A

1

1

High-throughput

0.536

High

135848

GP182
G-protein coupled receptor 182

1

20

High-throughput

0.536

High

135849

ACTN4
Alpha-actinin-4

1

3

High-throughput

0.536

High

135855

AUXI
Auxilin

1

1

High-throughput

0.536

High

135866

PGK1
Phosphoglycerate kinase 1

1

1

High-throughput

0.536

High

135883

FLNA
Filamin-A

1

3

High-throughput

0.536

High

135884

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

1

High-throughput

0.536

High

135885

SYTC
Threonine--tRNA ligase 1, cytoplasmic

1

1

High-throughput

0.536

High

135891

ARRB2
Beta-arrestin-2

1

2

High-throughput

0.536

High

135894

MYH9
Myosin-9

1

6

High-throughput

0.536

High

135897

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

2

High-throughput

0.536

High

135898

CAZA2
F-actin-capping protein subunit alpha-2

1

1

High-throughput

0.536

High

135899

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.536

High

135901

ARRB1
Beta-arrestin-1

1

2

High-throughput

0.536

High

135912

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

3

High-throughput

0.536

High

135917

CLH1
Clathrin heavy chain 1

1

6

High-throughput

0.536

High

135919

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

8

High-throughput

0.536

High

135922

LG3BP
Galectin-3-binding protein

1

4

High-throughput

0.536

High

135924

TIF1B
Transcription intermediary factor 1-beta

1

4

High-throughput

0.536

High

135928

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

4

High-throughput

0.536

High

135933

P2RY6
P2Y purinoceptor 6

1

20

High-throughput

0.536

High

135934

TEBP
Prostaglandin E synthase 3

1

3

High-throughput

0.536

High

135937

SC23A
Protein transport protein Sec23A

1

1

High-throughput

0.536

High

135938

OASL
2'-5'-oligoadenylate synthase-like protein

1

3

High-throughput

0.536

High

135940

DREB
Drebrin

1

4

High-throughput

0.536

High

135969

YLAT2
Y+L amino acid transporter 2

1

4

High-throughput

0.536

High

135971

MY18A
Unconventional myosin-XVIIIa

1

9

High-throughput

0.536

High

135975

EFMT3
EEF1A lysine methyltransferase 3

1

2

High-throughput

0.536

High

135979

MYO19
Unconventional myosin-XIX

1

10

High-throughput

0.536

High

135981

TMM74
Transmembrane protein 74

1

2

High-throughput

0.536

High

135988

DUS16
Dual specificity protein phosphatase 16

1

3

High-throughput

0.536

High

135989

WNK3
Serine/threonine-protein kinase WNK3

1

4

High-throughput

0.536

High

136009

ANFY1
Rabankyrin-5

1

1

High-throughput

0.536

High

136010

LIMA1
LIM domain and actin-binding protein 1

1

3

High-throughput

0.536

High

136016

PA2G4
Proliferation-associated protein 2G4

1

3

High-throughput

0.536

High

136018

LRCH1
Leucine-rich repeat and calponin homology domain-containing protein 1

1

1

High-throughput

0.536

High

136021

STK24
Serine/threonine-protein kinase 24

1

10

High-throughput

0.536

High

135998

DUS21
Dual specificity protein phosphatase 21

1

3

High-throughput

0.515

High

135860

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

0

High-throughput

0.513

High

135863

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.513

High

135864

AL1A1
Aldehyde dehydrogenase 1A1

1

0

High-throughput

0.513

High

135872

PROF1
Profilin-1

1

0

High-throughput

0.513

High

135880

NQO1
NAD(P)H dehydrogenase [quinone] 1

1

0

High-throughput

0.513

High

135882

CAN2
Calpain-2 catalytic subunit

1

0

High-throughput

0.513

High

135905

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.513

High

135916

TYB10
Thymosin beta-10

1

0

High-throughput

0.513

High

135944

EFMT2
EEF1A lysine methyltransferase 2

1

0

High-throughput

0.513

High

135952

LYPD4
Ly6/PLAUR domain-containing protein 4

1

0

High-throughput

0.513

High

135959

POGZ
Pogo transposable element with ZNF domain

1

0

High-throughput

0.513

High

135964

SYNPO
Synaptopodin

1

0

High-throughput

0.513

High

135991

IF5A2
Eukaryotic translation initiation factor 5A-2

1

0

High-throughput

0.513

High

135994

CXL16
C-X-C motif chemokine 16

1

0

High-throughput

0.513

High

136001

PAAT
ATPase PAAT

1

0

High-throughput

0.513

High

136005

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.513

High

136007

GTSE1
G2 and S phase-expressed protein 1

1

0

High-throughput

0.513

High

136020

BACE2
Beta-secretase 2

1

0

High-throughput

0.513

High

74389

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

1

High-throughput

0.489

High

135896

MAGA9
Melanoma-associated antigen 9

1

2

High-throughput

0.489

High

135983

MA7D2
MAP7 domain-containing protein 2

1

9

High-throughput

0.489

High

124867

GTPB1
GTP-binding protein 1

1

2

High-throughput

0.479

High

135851

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.479

High

135852

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

135854

DNJA2
DnaJ homolog subfamily A member 2

1

2

High-throughput

0.479

High

135856

NU155
Nuclear pore complex protein Nup155

1

2

High-throughput

0.479

High

135858

TRI37
E3 ubiquitin-protein ligase TRIM37

1

10

High-throughput

0.479

High

135859

KI20A
Kinesin-like protein KIF20A

1

9

High-throughput

0.479

High

135862

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

3

High-throughput

0.479

High

135867

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.479

High

135871

NTRK1
High affinity nerve growth factor receptor

1

17

High-throughput

0.479

High

135873

VIME
Vimentin

1

3

High-throughput

0.479

High

135878

TRI27
Zinc finger protein RFP

1

1

Small-scale

0.479

High

135881

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

135887

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

135890

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

135893

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

135895

MLH1
DNA mismatch repair protein Mlh1

1

3

High-throughput

0.479

High

135904

AK1C2
Aldo-keto reductase family 1 member C2

1

2

High-throughput

0.479

High

135906

PMS1
PMS1 protein homolog 1

1

3

High-throughput

0.479

High

135907

PMS2
Mismatch repair endonuclease PMS2

1

3

High-throughput

0.479

High

135914

AP2B1
AP-2 complex subunit beta

1

3

High-throughput

0.479

High

135927

SQSTM
Sequestosome-1

1

4

High-throughput

0.479

High

135929

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

14

High-throughput

0.479

High

135930

UBP2L
Ubiquitin-associated protein 2-like

1

2

High-throughput

0.479

High

135932

KIF14
Kinesin-like protein KIF14

1

7

High-throughput

0.479

High

135949

LTOR1
Ragulator complex protein LAMTOR1

1

5

High-throughput

0.479

High

135953

SYNE3
Nesprin-3

1

10

High-throughput

0.479

High

135954

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.479

High

135957

ATG9A
Autophagy-related protein 9A

1

1

High-throughput

0.479

High

135958

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

135960

YTHD3
YTH domain-containing family protein 3

1

2

High-throughput

0.479

High

135963

RHG18
Rho GTPase-activating protein 18

1

1

High-throughput

0.479

High

135968

SMAP2
Stromal membrane-associated protein 2

1

2

High-throughput

0.479

High

135972

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

High-throughput

0.479

High

135973

ESR2
Estrogen receptor beta

1

10

High-throughput

0.479

High

135974

CSN5
COP9 signalosome complex subunit 5

1

3

High-throughput

0.479

High

135986

LZTS2
Leucine zipper putative tumor suppressor 2

1

15

High-throughput

0.479

High

135993

ATG5
Autophagy protein 5

1

1

High-throughput

0.479

High

135995

PTN23
Tyrosine-protein phosphatase non-receptor type 23

1

3

Small-scale

0.479

High

135999

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

136011

ANC2
Anaphase-promoting complex subunit 2

1

5

High-throughput

0.479

High

136014

MYO6
Unconventional myosin-VI

1

8

Small-scale

0.479

High

136015

MAGD2
Melanoma-associated antigen D2

1

2

High-throughput

0.479

High

136017

NINL
Ninein-like protein

1

10

High-throughput

0.479

High

136022

CABIN
Calcineurin-binding protein cabin-1

1

2

High-throughput

0.479

High

135888

TKT
Transketolase

1

0

High-throughput

0.458

High

135945

SMAG2
Protein Smaug homolog 2

1

0

High-throughput

0.458

High

135961

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.458

High

135966

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

135970

CNOT9
CCR4-NOT transcription complex subunit 9

1

0

High-throughput

0.458

High

135984

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.458

High

135987

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

0

High-throughput

0.458

High

136000

TDRD3
Tudor domain-containing protein 3

1

0

High-throughput

0.458

High

135939

EREP1
Endosomal transmembrane epsin interactor 1

1

1

Small-scale

0.457

High

135853

AP180
Clathrin coat assembly protein AP180

1

1

High-throughput

0.445

High

135865

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.445

High

135870

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

18

Small-scale

0.445

High

135892

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.445

High

135908

RD23A
UV excision repair protein RAD23 homolog A

1

4

High-throughput

0.445

High

135920

AK1C1
Aldo-keto reductase family 1 member C1

1

2

High-throughput

0.445

High

135943

KLH22
Kelch-like protein 22

1

4

High-throughput

0.445

High

135955

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

3

High-throughput

0.445

High

135978

AURKB
Aurora kinase B

1

5

High-throughput

0.445

High

135990

ZDHC5
Palmitoyltransferase ZDHHC5

1

5

High-throughput

0.445

High

135902

TSP3
Thrombospondin-3

1

1

High-throughput

0.437

High

135936

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

1

High-throughput

0.437

High

135918

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

0

High-throughput

0.426

High

135992

DJC25
DnaJ homolog subfamily C member 25

1

1

High-throughput

0.407

High

136008

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

3

High-throughput

0.407

High

135947

CF141
Uncharacterized protein C6orf141

2

0

High-throughput

0.328

High

135941

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

135982

ARX
Homeobox protein ARX

1

0

High-throughput

0.279

Low

135965

S2541
Mitochondrial carrier protein SCaMC-3L

1

0

High-throughput

0.249

Low

136006

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

0

High-throughput

0.249

Low

135874

CEL3A
Chymotrypsin-like elastase family member 3A

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025