HitPredict - High confidence protein-protein interactions

Interactor 1: XRCC6 (P12956)
X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6)
Gene: XRCC6

Interactor 2: XRCC5 (P13010)
X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining))
Gene: XRCC5

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.99	1.00	0.996

Property	Details
Experiments	18809223, 26496610, 19906305, 28514442, 26446488, 7699019, 30585729, 10219089, 30021884, 10984620, 33005030, 33961781, 10446239, 22451927, 35031618, 27402161, 29655301, 37071682, 12145306, 15520013 and 29 others more... 15023334, 10783163, 21454661, 15367688, 15910003, 11493912, 10757784, 19177010, 19118032, 10750018, 17159921, 28035050, 26774286, 32296183, 10207052, 24981860, 30017584, 9813006, 35235311, 21172662, 21070772, 21679440, 11196700, 25574025, 24098118, 17283121, 17308091, unassigned1304, 23178593
Identification Methods	pull down, affinity chromatography technology, proximity labelling technology, two hybrid, cross-linking study, x-ray crystallography, enzymatic study, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, validated two hybrid and 6 others more... electron microscopy, filter binding, two hybrid array, two hybrid prey pooling approach, tandem affinity purification, biochemical
Interaction Type	direct interaction, physical association, association, phosphorylation reaction

Property	Details
Interacting Pfam domains	Ku~Ku, Ku~Ku_C, Ku~Ku_N, Ku_C~Ku_N, Ku_C~Ku_PK_bind, Ku_N~Ku_N, Ku_C~SAP, Ku_N~SAP
Common GO terms	GO:0000723 - telomere maintenance GO:0000725 - recombinational repair GO:0000781 - chromosome, telomeric region GO:0000783 - nuclear telomere cap complex GO:0000976 - transcription cis-regulatory region binding and 32 others more... GO:0002218 - activation of innate immune response GO:0003677 - DNA binding GO:0003678 - DNA helicase activity GO:0003684 - damaged DNA binding GO:0003690 - double-stranded DNA binding GO:0003723 - RNA binding GO:0005524 - ATP binding GO:0005576 - extracellular region GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0005829 - cytosol GO:0005958 - DNA-dependent protein kinase-DNA ligase 4 complex GO:0006303 - double-strand break repair via nonhomologous end joining GO:0008094 - ATP-dependent activity, acting on DNA GO:0016020 - membrane GO:0016887 - ATP hydrolysis activity GO:0032991 - protein-containing complex GO:0032993 - protein-DNA complex GO:0034774 - secretory granule lumen GO:0042162 - telomeric DNA binding GO:0043564 - Ku70:Ku80 complex GO:0044877 - protein-containing complex binding GO:0045087 - innate immune response GO:0045860 - positive regulation of protein kinase activity GO:0045892 - negative regulation of DNA-templated transcription GO:0048660 - regulation of smooth muscle cell proliferation GO:0070418 - DNA-dependent protein kinase complex GO:0070419 - nonhomologous end joining complex GO:0071475 - cellular hyperosmotic salinity response GO:0071480 - cellular response to gamma radiation GO:0071481 - cellular response to X-ray
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1	609
Hs

1	732

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Last updated: 15 Jul 2024