HitPredict

Interactor 1: XRCC6 (P12956)
X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6)
Gene: XRCC6

Interactor 2: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 609 Hs			1 780
+	Hs
		523734 XRCC6_HUMAN (1-609): 0: 666: 100.00		CUL3_HUMAN (8-780): 0: 754: 22.96
+	Hs
		523735 XRCC6_HUMAN (1-609): 0: 666: 100.00		CUL4A_HUMAN (16-780): 0: 744: 24.48
+	Hs
		523736 XRCC6_HUMAN (1-609): 0: 666: 100.00		CUL4B_HUMAN (16-780): 0: 736: 25.39
+	Hs
		524916 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		CUL3_HUMAN (8-780): 0: 754: 22.96