Protein: EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

Gene: EDEM1
Organism: Homo sapiens
Interactions: 210
UniProt ID: Q92611

Gene Ontology (top 5):
GO:0004571 - mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005509 - calcium ion binding
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005975 - carbohydrate metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

452350

PDIA1
Protein disulfide-isomerase

2

11

High-throughput

0.789

High

1312025

DJC10
DnaJ homolog subfamily C member 10

2

14

Small-scale

0.754

High

698963

CALX
Calnexin

5

7

Small-scale

0.709

High

1365525

SE1L1
Protein sel-1 homolog 1

5

4

Small-scale

0.702

High

566777

PDIA4
Protein disulfide-isomerase A4

1

10

Small-scale

0.618

High

1365478

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

4

High-throughput

0.618

High

1365498

ERP44
Endoplasmic reticulum resident protein 44

1

12

High-throughput

0.618

High

1365502

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

4

High-throughput

0.618

High

1365531

MA1B1
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

1

4

High-throughput

0.618

High

1365527

UBQL2
Ubiquilin-2

2

2

High-throughput

0.611

High

1034789

NAAA
N-acylethanolamine-hydrolyzing acid amidase

3

2

High-throughput

0.609

High

1192269

ZACN
Ligand-gated cation channel ZACN

3

3

High-throughput

0.609

High

369376

A1AT
Alpha-1-antitrypsin

2

1

Small-scale

0.584

High

573600

ENPL
Endoplasmin

2

2

Small-scale

0.584

High

1105528

OS9
Protein OS-9

2

4

Small-scale

0.584

High

1365517

DJB12
DnaJ homolog subfamily B member 12

2

5

Small-scale

0.584

High

1365520

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

2

2

Small-scale

0.584

High

1365524

DJB11
DnaJ homolog subfamily B member 11

2

1

Small-scale

0.584

High

1248776

LYZL1
Lysozyme-like protein 1

2

3

High-throughput

0.574

High

1278868

LYZL2
Lysozyme-like protein 2

2

3

High-throughput

0.574

High

1365521

MTCH1
Mitochondrial carrier homolog 1

2

2

High-throughput

0.574

High

1107980

SQSTM
Sequestosome-1

2

0

Small-scale

0.559

High

1365538

UB2J1
Ubiquitin-conjugating enzyme E2 J1

2

0

Small-scale

0.559

High

945943

LOXL3
Lysyl oxidase homolog 3

2

2

High-throughput

0.558

High

1227178

A16L1
Autophagy-related protein 16-1

2

1

High-throughput

0.521

High

847631

SSRA
Translocon-associated protein subunit alpha

1

1

Small-scale

0.515

High

138253

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

0

High-throughput

0.513

High

249497

ACSL4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.513

High

1191785

VMA21
Vacuolar ATPase assembly integral membrane protein VMA21

1

0

High-throughput

0.513

High

1244892

NCEH1
Neutral cholesterol ester hydrolase 1

1

0

High-throughput

0.513

High

1329778

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.513

High

1365499

ESYT1
Extended synaptotagmin-1

1

0

High-throughput

0.513

High

416636

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

2

High-throughput

0.489

High

851193

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

3

High-throughput

0.489

High

1204562

NMS
Neuromedin-S

1

1

High-throughput

0.489

High

1219232

CDCP2
CUB domain-containing protein 2

1

1

High-throughput

0.489

High

1365479

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

1

1

High-throughput

0.489

High

1365485

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

1

High-throughput

0.489

High

1365491

LCFC1
Sperm-egg fusion protein LLCFC1

1

1

High-throughput

0.489

High

122634

UBXN8
UBX domain-containing protein 8

1

3

High-throughput

0.479

High

135665

DNM1L
Dynamin-1-like protein

1

1

High-throughput

0.479

High

178349

NPC1
NPC intracellular cholesterol transporter 1

1

2

High-throughput

0.479

High

226841

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

3

High-throughput

0.479

High

283324

ERLN1
Erlin-1

1

3

High-throughput

0.479

High

321320

ERLN2
Erlin-2

1

3

High-throughput

0.479

High

326594

MFN2
Mitofusin-2

1

1

High-throughput

0.479

High

326969

UBE4B
Ubiquitin conjugation factor E4 B

1

2

High-throughput

0.479

High

363653

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.479

High

417642

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

2

High-throughput

0.479

High

424239

S10A8
Protein S100-A8

1

1

High-throughput

0.479

High

445039

S10A9
Protein S100-A9

1

1

High-throughput

0.479

High

455995

ASGR2
Asialoglycoprotein receptor 2

1

4

Small-scale

0.479

High

461772

HS90A
Heat shock protein HSP 90-alpha

1

2

High-throughput

0.479

High

535363

BIP
Endoplasmic reticulum chaperone BiP

1

4

High-throughput

0.479

High

537622

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

656208

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

2

Small-scale

0.479

High

697973

CALR
Calreticulin

1

7

High-throughput

0.479

High

813180

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

2

High-throughput

0.479

High

839330

MTOR
Serine/threonine-protein kinase mTOR

1

1

High-throughput

0.479

High

863523

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

4

High-throughput

0.479

High

880632

LMAN1
Protein ERGIC-53

1

3

High-throughput

0.479

High

975475

PRS10
26S proteasome regulatory subunit 10B

1

1

High-throughput

0.479

High

1006155

PI42B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

1

2

High-throughput

0.479

High

1098455

DNJC3
DnaJ homolog subfamily C member 3

1

6

High-throughput

0.479

High

1121133

UBE4A
Ubiquitin conjugation factor E4 A

1

2

High-throughput

0.479

High

1149260

SHH
Sonic hedgehog protein

1

2

Small-scale

0.479

High

1180297

ATG2A
Autophagy-related protein 2 homolog A

1

2

High-throughput

0.479

High

1181409

P3H1
Prolyl 3-hydroxylase 1

1

1

Small-scale

0.479

High

1219315

ECM29
Proteasome adapter and scaffold protein ECM29

1

2

High-throughput

0.479

High

1238173

RHBD2
Rhomboid domain-containing protein 2

1

2

High-throughput

0.479

High

1259218

TMUB2
Transmembrane and ubiquitin-like domain-containing protein 2

1

1

High-throughput

0.479

High

1276258

ATG9A
Autophagy-related protein 9A

1

1

High-throughput

0.479

High

1287396

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

2

High-throughput

0.479

High

1349204

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

2

High-throughput

0.479

High

1349801

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

4

High-throughput

0.479

High

1352327

RHBL4
Rhomboid-related protein 4

1

1

High-throughput

0.479

High

1353396

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

1

1

High-throughput

0.479

High

1356224

RN139
E3 ubiquitin-protein ligase RNF139

1

2

High-throughput

0.479

High

1365033

UBXN4
UBX domain-containing protein 4

1

3

High-throughput

0.479

High

1365482

ATG2B
Autophagy-related protein 2 homolog B

1

2

High-throughput

0.479

High

1365483

FAF2
FAS-associated factor 2

1

3

High-throughput

0.479

High

1365484

ERLEC
Endoplasmic reticulum lectin 1

1

4

High-throughput

0.479

High

1365492

VP13A
Intermembrane lipid transfer protein VPS13A

1

3

High-throughput

0.479

High

1365496

RNF5
E3 ubiquitin-protein ligase RNF5

1

1

High-throughput

0.479

High

1365501

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

1

1

High-throughput

0.479

High

1365510

ZFYV1
Zinc finger FYVE domain-containing protein 1

1

2

High-throughput

0.479

High

1365514

FBX6
F-box only protein 6

1

2

High-throughput

0.479

High

1365519

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

1

4

High-throughput

0.479

High

1365523

DNJB9
DnaJ homolog subfamily B member 9

1

5

High-throughput

0.479

High

1365528

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

1

1

High-throughput

0.479

High

1365532

AMFR
E3 ubiquitin-protein ligase AMFR

1

3

High-throughput

0.479

High

1365533

UBQL1
Ubiquilin-1

1

1

High-throughput

0.479

High

1365535

CHIP
E3 ubiquitin-protein ligase CHIP

1

2

High-throughput

0.479

High

1365536

FAF1
FAS-associated factor 1

1

3

High-throughput

0.479

High

1365542

HYOU1
Hypoxia up-regulated protein 1

1

6

High-throughput

0.479

High

1365545

TX264
Testis-expressed protein 264

1

1

High-throughput

0.479

High

1271300

5MP2
eIF5-mimic protein 2

1

1

High-throughput

0.470

High

161235

EI24
Etoposide-induced protein 2.4 homolog

1

0

High-throughput

0.458

High

301600

WFS1
Wolframin

1

0

High-throughput

0.458

High

414320

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

422753

A4
Amyloid-beta precursor protein

1

0

Small-scale

0.458

High

457116

CAN1
Calpain-1 catalytic subunit

1

0

High-throughput

0.458

High

483942

HMOX1
Heme oxygenase 1

1

0

High-throughput

0.458

High

627999

ANXA7
Annexin A7

1

0

High-throughput

0.458

High

843823

HD
Huntingtin

1

0

High-throughput

0.458

High

906128

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

0

High-throughput

0.458

High

934934

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

943107

STX17
Syntaxin-17

1

0

High-throughput

0.458

High

951314

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

1125172

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

0

High-throughput

0.458

High

1126729

BECN1
Beclin-1

1

0

High-throughput

0.458

High

1197261

MBRL
Membralin

1

0

High-throughput

0.458

High

1231449

ATLA3
Atlastin-3

1

0

High-throughput

0.458

High

1272409

GET4
Golgi to ER traffic protein 4 homolog

1

0

High-throughput

0.458

High

1288214

LYRIC
Protein LYRIC

1

0

High-throughput

0.458

High

1310011

FXRD2
FAD-dependent oxidoreductase domain-containing protein 2

1

0

High-throughput

0.458

High

1347625

NPL4
Nuclear protein localization protein 4 homolog

1

0

High-throughput

0.458

High

1351919

RBCC1
RB1-inducible coiled-coil protein 1

1

0

High-throughput

0.458

High

1365480

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.458

High

1365481

VTI1A
Vesicle transport through interaction with t-SNAREs homolog 1A

1

0

High-throughput

0.458

High

1365488

VMP1
Vacuole membrane protein 1

1

0

High-throughput

0.458

High

1365494

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

1365497

SELS
Selenoprotein S

1

0

Small-scale

0.458

High

1365503

DERL2
Derlin-2

1

0

High-throughput

0.458

High

1365507

ANKZ1
tRNA endonuclease ANKZF1

1

0

High-throughput

0.458

High

1365508

RN121
E3 ubiquitin ligase RNF121

1

0

High-throughput

0.458

High

1365511

EPG5
Ectopic P granules protein 5 homolog

1

0

High-throughput

0.458

High

1365539

FBX7
F-box only protein 7

1

0

High-throughput

0.458

High

1365544

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

0

High-throughput

0.458

High

170902

CLGN
Calmegin

1

7

High-throughput

0.445

High

1243642

S27A1
Long-chain fatty acid transport protein 1

1

1

High-throughput

0.445

High

1365505

LMA2L
VIP36-like protein

1

3

High-throughput

0.445

High

136418

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

1

High-throughput

0.437

High

218565

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.437

High

334221

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

2

High-throughput

0.437

High

455927

ASGR1
Asialoglycoprotein receptor 1

1

4

Small-scale

0.437

High

465757

OPSD
Rhodopsin

1

2

Small-scale

0.437

High

476009

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

1

High-throughput

0.437

High

540598

LAMP1
Lysosome-associated membrane glycoprotein 1

1

1

High-throughput

0.437

High

562278

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.437

High

871990

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

2

High-throughput

0.437

High

1026155

CLH1
Clathrin heavy chain 1

1

1

High-throughput

0.437

High

1047069

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

1

High-throughput

0.437

High

1060276

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

1

1

High-throughput

0.437

High

1067555

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.437

High

1095426

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

2

High-throughput

0.437

High

1102217

ATM
Serine-protein kinase ATM

1

1

High-throughput

0.437

High

1106287

ROCK1
Rho-associated protein kinase 1

1

1

High-throughput

0.437

High

1107664

MTM1
Myotubularin

1

1

High-throughput

0.437

High

1112443

MTMR3
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3

1

1

High-throughput

0.437

High

1153206

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

2

High-throughput

0.437

High

1226584

MAP1S
Microtubule-associated protein 1S

1

1

High-throughput

0.437

High

1309726

MFN1
Mitofusin-1

1

1

High-throughput

0.437

High

1316757

WDFY3
WD repeat and FYVE domain-containing protein 3

1

1

High-throughput

0.437

High

1322606

RPTOR
Regulatory-associated protein of mTOR

1

2

High-throughput

0.437

High

1364951

TSC1
Hamartin

1

1

High-throughput

0.437

High

1365486

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

3

High-throughput

0.437

High

1365490

VPS39
Vam6/Vps39-like protein

1

1

High-throughput

0.437

High

1365518

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

1

High-throughput

0.437

High

1365522

VPS18
Vacuolar protein sorting-associated protein 18 homolog

1

1

High-throughput

0.437

High

1365526

TBK1
Serine/threonine-protein kinase TBK1

1

2

High-throughput

0.437

High

73839

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

1

High-throughput

0.407

High

85916

B9A025
Lysyl oxidase homolog

1

2

High-throughput

0.407

High

388655

C1QA
Complement C1q subcomponent subunit A

1

1

High-throughput

0.407

High

1365515

S22AB
Solute carrier family 22 member 11

1

3

High-throughput

0.407

High

1198734

MPPE1
Metallophosphoesterase 1

2

0

High-throughput

0.328

High

1365534

SUFU
Suppressor of fused homolog

2

0

High-throughput

0.328

High

407198

CD3D
T-cell surface glycoprotein CD3 delta chain

2

0

High-throughput

0.313

High

210466

MSH5
MutS protein homolog 5

1

0

High-throughput

0.279

Low

1186498

CHD9
Chromodomain-helicase-DNA-binding protein 9

1

0

High-throughput

0.279

Low

1310713

PHF6
PHD finger protein 6

1

0

High-throughput

0.279

Low

1311083

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

High-throughput

0.279

Low

1328489

M4A15
Membrane-spanning 4-domains subfamily A member 15

1

0

High-throughput

0.279

Low

1335811

GALT6
Polypeptide N-acetylgalactosaminyltransferase 6

1

0

High-throughput

0.279

Low

1339933

OR1M1
Olfactory receptor 1M1

1

0

High-throughput

0.279

Low

1353445

PNISR
Arginine/serine-rich protein PNISR

1

0

High-throughput

0.279

Low

1365506

XYLT2
Xylosyltransferase 2

1

0

High-throughput

0.279

Low

1365541

VPP2
V-type proton ATPase 116 kDa subunit a 2

1

0

High-throughput

0.279

Low

130562

SPT5H
Transcription elongation factor SPT5

1

0

High-throughput

0.249

Low

849475

NAMPT
Nicotinamide phosphoribosyltransferase

1

0

High-throughput

0.249

Low

890865

TSC2
Tuberin

1

0

High-throughput

0.249

Low

891706

GSK3B
Glycogen synthase kinase-3 beta

1

0

High-throughput

0.249

Low

901447

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.249

Low

942350

BACE1
Beta-secretase 1

1

0

High-throughput

0.249

Low

945678

SESN2
Sestrin-2

1

0

High-throughput

0.249

Low

1063487

GOGA2
Golgin subfamily A member 2

1

0

High-throughput

0.249

Low

1131089

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

0

High-throughput

0.249

Low

1214538

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

0

High-throughput

0.249

Low

1234814

RAB12
Ras-related protein Rab-12

1

0

High-throughput

0.249

Low

1245678

LARP1
La-related protein 1

1

0

High-throughput

0.249

Low

1272159

RRAGA
Ras-related GTP-binding protein A

1

0

High-throughput

0.249

Low

1290878

VPS36
Vacuolar protein-sorting-associated protein 36

1

0

High-throughput

0.249

Low

1365438

TBCD5
TBC1 domain family member 5

1

0

High-throughput

0.249

Low

1365487

CHMP6
Charged multivesicular body protein 6

1

0

High-throughput

0.249

Low

1365489

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

0

High-throughput

0.249

Low

1365493

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.249

Low

1365495

TS101
Tumor susceptibility gene 101 protein

1

0

High-throughput

0.249

Low

1365500

WAC
WW domain-containing adapter protein with coiled-coil

1

0

High-throughput

0.249

Low

1365504

MCLN1
Mucolipin-1

1

0

High-throughput

0.249

Low

1365512

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.249

Low

1365513

WDR6
tRNA

1

0

High-throughput

0.249

Low

1365516

ATG3
Ubiquitin-like-conjugating enzyme ATG3

1

0

High-throughput

0.249

Low

1365529

XPO7
Exportin-7

1

0

High-throughput

0.249

Low

1365530

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

0

High-throughput

0.249

Low

1365537

SHLB1
Endophilin-B1

1

0

High-throughput

0.249

Low

1365540

WIPI4
WD repeat domain phosphoinositide-interacting protein 4

1

0

High-throughput

0.249

Low

1365543

SAM50
Sorting and assembly machinery component 50 homolog

1

0

High-throughput

0.249

Low

1359215

CA054
Uncharacterized protein C1orf54

1

0

High-throughput

0.232

Low

1365509

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025