Protein: EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3 (EC 3.2.1.113) (Alpha-1,2-mannosidase EDEM3)

Gene: EDEM3
Organism: Homo sapiens
Interactions: 126
UniProt ID: Q9BZQ6

Gene Ontology (top 5):
GO:0004571 - mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005509 - calcium ion binding
GO:0005783 - endoplasmic reticulum
GO:0005788 - endoplasmic reticulum lumen
GO:0005975 - carbohydrate metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1415035

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

2

4

Small-scale

0.737

High

1334128

TXND5
Thioredoxin domain-containing protein 5

1

9

Small-scale

0.724

High

1418696

LOXE3
Hydroperoxide isomerase ALOXE3

2

1

High-throughput

0.628

High

452391

PDIA1
Protein disulfide-isomerase

1

11

Small-scale

0.618

High

566827

PDIA4
Protein disulfide-isomerase A4

1

10

Small-scale

0.618

High

717594

PDIA3
Protein disulfide-isomerase A3

1

11

Small-scale

0.618

High

1312049

DJC10
DnaJ homolog subfamily C member 10

1

14

Small-scale

0.618

High

1365502

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

4

High-throughput

0.618

High

1412137

ERP44
Endoplasmic reticulum resident protein 44

1

12

Small-scale

0.618

High

1105555

OS9
Protein OS-9

2

4

Small-scale

0.611

High

218738

TGON2
Trans-Golgi network integral membrane protein 2

2

5

Small-scale

0.584

High

1420139

FBX6
F-box only protein 6

2

2

High-throughput

0.584

High

1420151

SE1L1
Protein sel-1 homolog 1

2

4

Small-scale

0.584

High

229281

ANGL7
Angiopoietin-related protein 7

2

4

High-throughput

0.574

High

948021

DEF1
Neutrophil defensin 1

2

2

High-throughput

0.574

High

64384

CDHR4
Cadherin-related family member 4

1

3

High-throughput

0.536

High

182761

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.536

High

351800

LGI1
Leucine-rich glioma-inactivated protein 1

1

2

High-throughput

0.536

High

638515

FPR1
fMet-Leu-Phe receptor

1

1

High-throughput

0.536

High

1030212

IL5RA
Interleukin-5 receptor subunit alpha

1

3

High-throughput

0.536

High

1187418

SHSL1
Protein shisa-like-1

1

1

High-throughput

0.536

High

1194709

GXLT1
Glucoside xylosyltransferase 1

1

1

High-throughput

0.536

High

1420134

CHST8
Carbohydrate sulfotransferase 8

1

3

High-throughput

0.536

High

1420138

SDF2L
Stromal cell-derived factor 2-like protein 1

1

1

High-throughput

0.536

High

1420149

DNJB9
DnaJ homolog subfamily B member 9

1

5

High-throughput

0.536

High

1420141

TMPS4
Transmembrane protease serine 4

1

7

High-throughput

0.515

High

841929

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.513

High

1347292

FIBIN
Fin bud initiation factor homolog

1

0

High-throughput

0.513

High

133310

P2Y10
Putative P2Y purinoceptor 10

1

3

High-throughput

0.489

High

154880

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

1

1

High-throughput

0.489

High

168451

NCTR3
Natural cytotoxicity triggering receptor 3

1

1

High-throughput

0.489

High

506905

CFC1
Cryptic protein

1

1

High-throughput

0.489

High

567975

PRG2
Bone marrow proteoglycan

1

3

High-throughput

0.489

High

575701

GPIX
Platelet glycoprotein IX

1

3

High-throughput

0.489

High

731894

CEAM8
Cell adhesion molecule CEACAM8

1

3

High-throughput

0.489

High

935798

MFAP4
Microfibril-associated glycoprotein 4

1

4

High-throughput

0.489

High

1278877

LYZL2
Lysozyme-like protein 2

1

3

High-throughput

0.489

High

1291886

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

2

High-throughput

0.489

High

1308296

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

1

High-throughput

0.489

High

1333771

TM87A
Transmembrane protein 87A

1

1

High-throughput

0.489

High

1363136

CLC2B
C-type lectin domain family 2 member B

1

4

High-throughput

0.489

High

1369060

GGH
Gamma-glutamyl hydrolase

1

1

High-throughput

0.489

High

1383459

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

2

High-throughput

0.489

High

1384594

ESPB1
Epididymal sperm-binding protein 1

1

4

High-throughput

0.489

High

1396513

LCFC1
Sperm-egg fusion protein LLCFC1

1

1

High-throughput

0.489

High

1420135

KLK15
Kallikrein-15

1

5

High-throughput

0.489

High

1420137

LY9
T-lymphocyte surface antigen Ly-9

1

4

High-throughput

0.489

High

1420143

CBLN4
Cerebellin-4

1

3

High-throughput

0.489

High

1420152

BTNL2
Butyrophilin-like protein 2

1

2

High-throughput

0.489

High

1420157

GPR45
Probable G-protein coupled receptor 45

1

1

High-throughput

0.489

High

283354

ERLN1
Erlin-1

1

3

Small-scale

0.479

High

321348

ERLN2
Erlin-2

1

3

Small-scale

0.479

High

369395

A1AT
Alpha-1-antitrypsin

1

1

Small-scale

0.479

High

417731

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

2

Small-scale

0.479

High

535506

BIP
Endoplasmic reticulum chaperone BiP

1

4

Small-scale

0.479

High

537857

HSP7C
Heat shock cognate 71 kDa protein

1

2

Small-scale

0.479

High

573659

ENPL
Endoplasmin

1

2

Small-scale

0.479

High

698016

CALR
Calreticulin

1

7

Small-scale

0.479

High

699086

CALX
Calnexin

1

7

Small-scale

0.479

High

716225

ERP29
Endoplasmic reticulum resident protein 29

1

8

Small-scale

0.479

High

813210

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

2

Small-scale

0.479

High

847677

SSRA
Translocon-associated protein subunit alpha

1

1

Small-scale

0.479

High

863546

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

4

Small-scale

0.479

High

880674

LMAN1
Protein ERGIC-53

1

3

Small-scale

0.479

High

895648

SERPH
Serpin H1

1

2

Small-scale

0.479

High

922021

COPA
Coatomer subunit alpha

1

1

Small-scale

0.479

High

1090525

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

2

Small-scale

0.479

High

1131378

GANAB
Neutral alpha-glucosidase AB

1

1

Small-scale

0.479

High

1136350

EMC2
ER membrane protein complex subunit 2

1

1

Small-scale

0.479

High

1149264

SHH
Sonic hedgehog protein

1

2

Small-scale

0.479

High

1219335

ECM29
Proteasome adapter and scaffold protein ECM29

1

2

Small-scale

0.479

High

1349833

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

4

Small-scale

0.479

High

1388090

ERLEC
Endoplasmic reticulum lectin 1

1

4

Small-scale

0.479

High

1420145

ERAP1
Endoplasmic reticulum aminopeptidase 1

1

2

Small-scale

0.479

High

1420156

HYOU1
Hypoxia up-regulated protein 1

1

6

Small-scale

0.479

High

188991

TMPS2
Transmembrane protease serine 2

1

7

High-throughput

0.470

High

418419

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

Small-scale

0.458

High

469191

SRPRA
Signal recognition particle receptor subunit alpha

1

0

Small-scale

0.458

High

532941

CH60
60 kDa heat shock protein, mitochondrial

1

0

Small-scale

0.458

High

571513

GLU2B
Glucosidase 2 subunit beta

1

0

Small-scale

0.458

High

921774

COPB
Coatomer subunit beta

1

0

Small-scale

0.458

High

1116910

MOGS
Mannosyl-oligosaccharide glucosidase

1

0

Small-scale

0.458

High

1162155

MA2A1
Alpha-mannosidase 2

1

0

Small-scale

0.458

High

1330385

EMC1
ER membrane protein complex subunit 1

1

0

Small-scale

0.458

High

1394976

VCIP1
Deubiquitinating protein VCPIP1

1

0

Small-scale

0.458

High

1401687

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

0

Small-scale

0.458

High

1404573

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

0

Small-scale

0.458

High

1420146

HPBP1
Hsp70-binding protein 1

1

0

Small-scale

0.458

High

1420147

EMC3
ER membrane protein complex subunit 3

1

0

Small-scale

0.458

High

170944

CLGN
Calmegin

1

7

High-throughput

0.445

High

171572

S27A2
Long-chain fatty acid transport protein 2

1

1

High-throughput

0.445

High

1200303

FBLN7
Fibulin-7

1

2

High-throughput

0.445

High

1420155

XCT
Cystine/glutamate transporter

1

2

High-throughput

0.445

High

174608

TRI66
Tripartite motif-containing protein 66

1

1

High-throughput

0.437

High

344013

HS74L
Heat shock 70 kDa protein 4L

1

5

Small-scale

0.437

High

412572

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.437

High

647648

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

2

Small-scale

0.437

High

761505

HS71L
Heat shock 70 kDa protein 1-like

1

2

Small-scale

0.437

High

773628

COPB2
Coatomer subunit beta'

1

1

Small-scale

0.437

High

1255423

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

1308204

PLD3
5'-3' exonuclease PLD3

1

1

High-throughput

0.437

High

1365227

HS105
Heat shock protein 105 kDa

1

7

Small-scale

0.437

High

1400008

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

1

Small-scale

0.437

High

1420136

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.437

High

1420144

T106B
Transmembrane protein 106B

1

1

High-throughput

0.437

High

1420148

SAE1
SUMO-activating enzyme subunit 1

1

1

Small-scale

0.437

High

1420150

SAE2
SUMO-activating enzyme subunit 2

1

1

Small-scale

0.437

High

1420154

TRI33
E3 ubiquitin-protein ligase TRIM33

1

2

High-throughput

0.437

High

1420153

TNIK
TRAF2 and NCK-interacting protein kinase

1

1

High-throughput

0.417

High

2119

TVA20
T cell receptor alpha variable 20

1

1

High-throughput

0.407

High

944067

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.407

High

1227408

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.407

High

1420142

S22AB
Solute carrier family 22 member 11

1

3

High-throughput

0.407

High

139310

UPK2
Uroplakin-2

1

0

High-throughput

0.279

Low

224517

PI15
Peptidase inhibitor 15

1

0

High-throughput

0.279

Low

656023

CAH6
Carbonic anhydrase 6

1

0

High-throughput

0.279

Low

749271

CD70
CD70 antigen

1

0

High-throughput

0.279

Low

1411475

TM2D3
TM2 domain-containing protein 3

1

0

High-throughput

0.279

Low

415845

HSPB1
Heat shock protein beta-1

1

0

Small-scale

0.249

Low

938283

SEC13
Protein SEC13 homolog

1

0

Small-scale

0.249

Low

1157420

PSMD5
26S proteasome non-ATPase regulatory subunit 5

1

0

Small-scale

0.249

Low

1158523

CDC37
Hsp90 co-chaperone Cdc37

1

0

Small-scale

0.249

Low

1420140

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.238

Low

1219542

ANR22
Ankyrin repeat domain-containing protein 22

1

0

High-throughput

0.232

Low

1401865

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.232

Low

1419156

S17A9
Voltage-gated purine nucleotide uniporter SLC17A9

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025