HitPredict

Interactor 1: XRCC6 (P12956)
X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6)
Gene: XRCC6

Interactor 2: NR1H4 (Q96RI1)
Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14)
Gene: NR1H4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.586

Property	Details
Experiments	19833092
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000976 - transcription cis-regulatory region binding GO:0005654 - nucleoplasm GO:0045087 - innate immune response GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 609 Hs			1 486
+	Hs
		368895 XRCC6_HUMAN (1-609): 0: 666: 100.00		ESR1_HUMAN (10-486): 3.86e-118: 360: 21.91
+	Hs
		523513 XRCC6_HUMAN (1-609): 0: 666: 100.00		RXRA_HUMAN (11-485): 4.19e-119: 358: 20.78
+	Hs
		487891 XRCC6_HUMAN (1-609): 0: 666: 100.00		RARA_HUMAN (37-484): 3.76e-103: 317: 25.61
+	Hs
		523561 XRCC6_HUMAN (1-609): 0: 666: 100.00		PPARG_HUMAN (48-483): 3.41e-102: 317: 26.32
+	Hs
		500458 XRCC6_HUMAN (1-609): 0: 666: 100.00		THB_HUMAN (72-485): 1.08e-100: 311: 26.95
+	Mm
		617180 XRCC6_MOUSE (1-609): 0: 647: 82.92		ERR2_MOUSE (37-485): 5.61e-105: 321: 21.59
+	Hs
		525024 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		NR1H4_HUMAN (1-486): 6.66e-163: 471: 100.00
+	Hs
		500383 XRCC6_HUMAN (1-609): 0: 666: 100.00		THA_HUMAN (134-444): 4.36e-41: 155: 33.43
+	Hs
		368896 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		ESR1_HUMAN (10-486): 3.86e-118: 360: 21.91
+	Hs
		487892 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		RARA_HUMAN (37-484): 3.76e-103: 317: 25.61
+	Hs
		524818 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		PPARG_HUMAN (48-483): 3.41e-102: 317: 26.32
+	Hs
		524794 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		NR4A1_HUMAN (14-483): 1.12e-100: 316: 22.45
+	Hs
		500459 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		THB_HUMAN (72-485): 1.08e-100: 311: 26.95
+	Hs
		525003 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		ESR2_HUMAN (35-486): 2.01e-98: 307: 21.15
+	Hs
		500384 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		THA_HUMAN (134-444): 4.36e-41: 155: 33.43