Protein: AT2B4
Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4)

Gene: AT2B4, ATP2B4
Organism: Homo sapiens
Interactions: 181
UniProt ID: P23634

Gene Ontology (top 5):
GO:0003407 - neural retina development
GO:0005388 - P-type calcium transporter activity
GO:0005516 - calmodulin binding
GO:0005524 - ATP binding
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

661258

AT2B2
Plasma membrane calcium-transporting ATPase 2

2

15

High-throughput

0.811

High

627258

AT2B1
Plasma membrane calcium-transporting ATPase 1

2

15

High-throughput

0.754

High

661232

BASI
Basigin

5

11

High-throughput

0.712

High

661345

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

6

High-throughput

0.691

High

125240

LEG9
Galectin-9

4

11

High-throughput

0.691

High

609581

LEG3
Galectin-3

4

11

High-throughput

0.691

High

127280

LEG8
Galectin-8

3

11

High-throughput

0.667

High

162999

H17B6
17-beta-hydroxysteroid dehydrogenase type 6

3

11

High-throughput

0.667

High

332618

LYPD3
Ly6/PLAUR domain-containing protein 3

3

1

High-throughput

0.667

High

661229

AGTR1
Type-1 angiotensin II receptor

3

20

High-throughput

0.667

High

661235

PE2R3
Prostaglandin E2 receptor EP3 subtype

3

20

High-throughput

0.667

High

661256

DLK1
Protein delta homolog 1

3

2

High-throughput

0.667

High

661289

S39A4
Zinc transporter ZIP4

3

1

High-throughput

0.667

High

661341

TA2R7
Taste receptor type 2 member 7

3

1

High-throughput

0.667

High

661305

LIRB4
Leukocyte immunoglobulin-like receptor subfamily B member 4

3

7

High-throughput

0.662

High

374405

RASH
GTPase HRas

3

10

High-throughput

0.640

High

375182

RASK
GTPase KRas

3

15

High-throughput

0.640

High

661335

TNR27
Tumor necrosis factor receptor superfamily member 27

3

0

High-throughput

0.638

High

635150

CP2B6
Cytochrome P450 2B6

2

3

High-throughput

0.628

High

648806

KCNA5
Potassium voltage-gated channel subfamily A member 5

2

7

High-throughput

0.628

High

661222

FPR2
N-formyl peptide receptor 2

2

20

High-throughput

0.628

High

661231

APJ
Apelin receptor

2

20

High-throughput

0.628

High

661237

5HT3A
5-hydroxytryptamine receptor 3A

2

2

High-throughput

0.628

High

661260

VAC14
Protein VAC14 homolog

2

7

High-throughput

0.628

High

661272

C3AR
C3a anaphylatoxin chemotactic receptor

2

20

High-throughput

0.628

High

661307

F174A
Membrane protein FAM174A

2

5

High-throughput

0.628

High

661329

NMUR2
Neuromedin-U receptor 2

2

20

High-throughput

0.628

High

661334

IPPK
Inositol-pentakisphosphate 2-kinase

2

1

High-throughput

0.628

High

661347

RXLT1
Ribitol-5-phosphate xylosyltransferase 1

2

2

High-throughput

0.628

High

661349

PCDGD
Protocadherin gamma-B1

2

10

High-throughput

0.628

High

173860

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

16

High-throughput

0.618

High

661236

MUC18
Cell surface glycoprotein MUC18

1

4

High-throughput

0.618

High

661283

LEG9C
Galectin-9C

3

11

High-throughput

0.609

High

661313

WBP1
WW domain-binding protein 1

3

1

High-throughput

0.609

High

661230

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

2

0

High-throughput

0.602

High

661243

CCR6
C-C chemokine receptor type 6

2

20

High-throughput

0.601

High

661287

NIPA3
Magnesium transporter NIPA3

2

3

High-throughput

0.601

High

661309

LPAR1
Lysophosphatidic acid receptor 1

2

20

High-throughput

0.601

High

661317

OPALI
Opalin

2

5

High-throughput

0.601

High

661350

NPTN
Neuroplastin

2

11

High-throughput

0.601

High

373777

RASN
GTPase NRas

2

15

High-throughput

0.584

High

400292

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

3

High-throughput

0.584

High

661253

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.584

High

661239

NRAM2
Natural resistance-associated macrophage protein 2

2

0

High-throughput

0.576

High

516310

CALM1
Calmodulin-1

1

6

High-throughput

0.575

High

516384

CALM2
Calmodulin-2

1

6

High-throughput

0.575

High

516467

CALM3
Calmodulin-3

1

6

High-throughput

0.575

High

71194

HIDE1
Protein HIDE1

1

1

High-throughput

0.536

High

132567

UPK1A
Uroplakin-1a

1

15

High-throughput

0.536

High

133226

P2Y10
Putative P2Y purinoceptor 10

1

20

High-throughput

0.536

High

141817

ACKR2
Atypical chemokine receptor 2

1

20

High-throughput

0.536

High

165904

FFAR1
Free fatty acid receptor 1

1

20

High-throughput

0.536

High

221446

OX2R
Orexin receptor type 2

1

13

High-throughput

0.536

High

230939

TYOBP
TYRO protein tyrosine kinase-binding protein

1

1

High-throughput

0.536

High

270433

FZD7
Frizzled-7

1

5

High-throughput

0.536

High

351873

S1PR4
Sphingosine 1-phosphate receptor 4

1

20

High-throughput

0.536

High

362784

EGFR
Epidermal growth factor receptor

1

10

High-throughput

0.536

High

378609

IL2RA
Interleukin-2 receptor subunit alpha

1

3

High-throughput

0.536

High

563212

CFTR
Cystic fibrosis transmembrane conductance regulator

1

11

High-throughput

0.536

High

640366

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

20

High-throughput

0.536

High

661225

NK3R
Neuromedin-K receptor

1

20

High-throughput

0.536

High

661228

V2R
Vasopressin V2 receptor

1

19

High-throughput

0.536

High

661233

OPRX
Nociceptin receptor

1

20

High-throughput

0.536

High

661234

P2RY2
P2Y purinoceptor 2

1

20

High-throughput

0.536

High

661241

CDK7
Cyclin-dependent kinase 7

1

4

High-throughput

0.536

High

661254

KC1G2
Casein kinase I isoform gamma-2

1

5

High-throughput

0.536

High

661257

IDD
Integral membrane protein DGCR2/IDD

1

2

High-throughput

0.536

High

661262

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

20

High-throughput

0.536

High

661278

TTMP
TPA-induced transmembrane protein

1

1

High-throughput

0.536

High

661281

OR2G6
Olfactory receptor 2G6

1

1

High-throughput

0.536

High

661292

LHPL2
LHFPL tetraspan subfamily member 2 protein

1

1

High-throughput

0.536

High

661295

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

20

High-throughput

0.536

High

661300

CQ078
Uncharacterized protein C17orf78

1

4

High-throughput

0.536

High

661301

M4A15
Membrane-spanning 4-domains subfamily A member 15

1

1

High-throughput

0.536

High

661304

RN149
E3 ubiquitin-protein ligase RNF149

1

5

High-throughput

0.536

High

661320

TR13C
Tumor necrosis factor receptor superfamily member 13C

1

1

High-throughput

0.536

High

661321

KKCC2
Calcium/calmodulin-dependent protein kinase kinase 2

1

2

High-throughput

0.536

High

661323

KI2L4
Killer cell immunoglobulin-like receptor 2DL4

1

9

High-throughput

0.536

High

661324

CML1
Chemerin-like receptor 1

1

20

High-throughput

0.536

High

661326

SYT11
Synaptotagmin-11

1

1

High-throughput

0.536

High

661328

HCAR1
Hydroxycarboxylic acid receptor 1

1

20

High-throughput

0.536

High

661330

S22A4
Solute carrier family 22 member 4

1

7

High-throughput

0.536

High

661331

TTYH1
Protein tweety homolog 1

1

2

High-throughput

0.536

High

661336

RXFP1
Relaxin receptor 1

1

14

High-throughput

0.536

High

661337

ENTP7
Ectonucleoside triphosphate diphosphohydrolase 7

1

10

High-throughput

0.536

High

661340

GP173
Probable G-protein coupled receptor 173

1

13

High-throughput

0.536

High

661342

CCG4
Voltage-dependent calcium channel gamma-4 subunit

1

5

High-throughput

0.536

High

661343

CC018
Uncharacterized protein C3orf18

1

2

High-throughput

0.536

High

661344

CLC4A
C-type lectin domain family 4 member A

1

5

High-throughput

0.536

High

661322

ERBIN
Erbin

1

6

Small-scale

0.527

High

661303

SIDT2
SID1 transmembrane family member 2

1

0

High-throughput

0.513

High

661315

S41A3
Solute carrier family 41 member 3

1

0

High-throughput

0.513

High

661319

XPO6
Exportin-6

1

0

High-throughput

0.513

High

661351

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.513

High

168635

CSKP
Peripheral plasma membrane protein CASK

1

11

Small-scale

0.501

High

661261

DLG1
Disks large homolog 1

1

10

Small-scale

0.501

High

377248

CALC
Calcitonin [Cleaved into: Calcitonin

1

1

Small-scale

0.500

High

528421

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

0

High-throughput

0.493

High

253812

TPST2
Protein-tyrosine sulfotransferase 2

1

5

High-throughput

0.489

High

661221

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

1

High-throughput

0.489

High

661276

LEG9B
Galectin-9B

1

11

High-throughput

0.489

High

661312

OPTN
Optineurin

1

4

High-throughput

0.489

High

181684

CTDSL
CTD small phosphatase-like protein

1

4

High-throughput

0.479

High

293212

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.479

High

417951

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

5

High-throughput

0.479

High

458281

ADRB2
Beta-2 adrenergic receptor

1

13

High-throughput

0.479

High

463336

LYN
Tyrosine-protein kinase Lyn

1

5

High-throughput

0.479

High

541345

FGFR1
Fibroblast growth factor receptor 1

1

13

High-throughput

0.479

High

555878

CADH1
Cadherin-1

1

6

High-throughput

0.479

High

603837

CXA1
Gap junction alpha-1 protein

1

8

High-throughput

0.479

High

661223

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.479

High

661224

EPHA2
Ephrin type-A receptor 2

1

7

High-throughput

0.479

High

661226

NOS3
Nitric oxide synthase 3

1

7

Small-scale

0.479

High

661227

MARCS
Myristoylated alanine-rich C-kinase substrate

1

2

High-throughput

0.479

High

661242

RAB9A
Ras-related protein Rab-9A

1

10

High-throughput

0.479

High

661246

HSP72
Heat shock-related 70 kDa protein 2

1

2

High-throughput

0.479

High

661249

SC61B
Protein transport protein Sec61 subunit beta

1

4

High-throughput

0.479

High

661252

ARF6
ADP-ribosylation factor 6

1

3

High-throughput

0.479

High

661259

CAV1
Caveolin-1

1

4

High-throughput

0.479

High

661263

SNTA1
Alpha-1-syntrophin

1

15

Small-scale

0.479

High

661264

STIM1
Stromal interaction molecule 1

1

2

Small-scale

0.479

High

661265

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

3

High-throughput

0.479

High

661267

EI2BA
Translation initiation factor eIF2B subunit alpha

1

2

High-throughput

0.479

High

661270

RAB35
Ras-related protein Rab-35

1

4

High-throughput

0.479

High

661271

DLG2
Disks large homolog 2

1

11

Small-scale

0.479

High

661273

OCLN
Occludin

1

2

High-throughput

0.479

High

661284

LTOR1
Ragulator complex protein LAMTOR1

1

2

High-throughput

0.479

High

661285

STYK1
Tyrosine-protein kinase STYK1

1

9

High-throughput

0.479

High

661290

LMBRL
Protein LMBR1L

1

3

High-throughput

0.479

High

661293

TM11B
Transmembrane protease serine 11B

1

6

High-throughput

0.479

High

661302

EMC1
ER membrane protein complex subunit 1

1

3

High-throughput

0.479

High

661310

DLG3
Disks large homolog 3

1

10

Small-scale

0.479

High

661316

SNX27
Sorting nexin-27

1

17

High-throughput

0.479

High

661327

DERL1
Derlin-1

1

3

High-throughput

0.479

High

661332

DNJC5
DnaJ homolog subfamily C member 5

1

1

High-throughput

0.479

High

661333

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.479

High

661338

TMPS4
Transmembrane protease serine 4

1

6

High-throughput

0.479

High

661339

RASF1
Ras association domain-containing protein 1

1

3

Small-scale

0.479

High

167572

GIPC1
PDZ domain-containing protein GIPC1

1

0

High-throughput

0.458

High

661277

TM52B
Transmembrane protein 52B

1

0

High-throughput

0.458

High

661348

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.458

High

67072

S38A8
Solute carrier family 38 member 8

1

3

High-throughput

0.445

High

126998

APBB1
Amyloid beta precursor protein binding family B member 1

1

4

High-throughput

0.445

High

351204

MOT3
Monocarboxylate transporter 3

1

10

High-throughput

0.445

High

529101

TAU
Microtubule-associated protein tau

1

18

High-throughput

0.445

High

540983

PIM1
Serine/threonine-protein kinase pim-1

1

2

High-throughput

0.445

High

641911

CD9
CD9 antigen

1

14

High-throughput

0.445

High

652176

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

1

10

High-throughput

0.445

High

653133

HEMH
Ferrochelatase, mitochondrial

1

3

High-throughput

0.445

High

661238

S6A12
Sodium- and chloride-dependent betaine transporter

1

3

High-throughput

0.445

High

661240

CXCR3
C-X-C chemokine receptor type 3

1

20

High-throughput

0.445

High

661244

CCR9
C-C chemokine receptor type 9

1

20

High-throughput

0.445

High

661247

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.445

High

661248

CD81
CD81 antigen

1

14

High-throughput

0.445

High

661250

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

5

High-throughput

0.445

High

661251

1433E
14-3-3 protein epsilon

1

6

Small-scale

0.445

High

661266

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

10

High-throughput

0.445

High

661268

MFS10
Major facilitator superfamily domain-containing protein 10

1

8

High-throughput

0.445

High

661269

S39AE
Metal cation symporter ZIP14

1

1

High-throughput

0.445

High

661274

S35G1
Solute carrier family 35 member G1

1

7

High-throughput

0.445

High

661286

MFSD5
Molybdate-anion transporter

1

1

High-throughput

0.445

High

661288

S27A4
Long-chain fatty acid transport protein 4

1

4

High-throughput

0.445

High

661298

S22A9
Organic anion transporter 7

1

8

High-throughput

0.445

High

661306

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

1

High-throughput

0.445

High

661308

S35F5
Solute carrier family 35 member F5

1

5

High-throughput

0.445

High

661318

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

3

High-throughput

0.445

High

661346

ITM2B
Integral membrane protein 2B

1

12

High-throughput

0.445

High

661245

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

3

High-throughput

0.437

High

661291

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.437

High

661296

TMM17
Transmembrane protein 17

1

2

High-throughput

0.437

High

661297

PLD3
5'-3' exonuclease PLD3

1

1

High-throughput

0.437

High

661311

CK052
Uncharacterized protein C11orf52

1

2

High-throughput

0.437

High

661299

S35F3
Solute carrier family 35 member F3

1

0

High-throughput

0.426

High

661255

S35A2
UDP-galactose translocator

1

8

High-throughput

0.407

High

661275

ATG2A
Autophagy-related protein 2 homolog A

1

1

Small-scale

0.407

High

661280

S35F1
Solute carrier family 35 member F1

1

11

High-throughput

0.407

High

661314

S35A4
Probable UDP-sugar transporter protein SLC35A4

1

8

High-throughput

0.407

High

661325

S35A5
UDP-sugar transporter protein SLC35A5

1

8

High-throughput

0.407

High

661279

PLAC9
Placenta-specific protein 9

1

0

High-throughput

0.279

Low

661282

RNLS
Renalase

1

0

Small-scale

0.269

Low

661294

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025