HitPredict

Interactor 1: XRCC5 (P13010)
X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining))
Gene: XRCC5

Interactor 2: ATM (Q13315)
Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated)
Gene: ATM

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

The method score is based on:

Property	Details
Experiments	17171639, 30017584, 15758953
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000723 - telomere maintenance GO:0003677 - DNA binding GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 9 others more... GO:0005730 - nucleolus GO:0005829 - cytosol GO:0006302 - double-strand break repair GO:0006303 - double-strand break repair via nonhomologous end joining GO:0006974 - DNA damage response GO:0032212 - positive regulation of telomere maintenance via telomerase GO:0044877 - protein-containing complex binding GO:0071480 - cellular response to gamma radiation GO:0071481 - cellular response to X-ray
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	732
Hs

1	3056

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024