Protein: DLDH
Dihydrolipoyl dehydrogenase, mitochondrial (DLD) (EC 1.8.1.4) (2-oxoglutarate dehydrogenase complex component E3) (OGDC-E3) (OGDHC subunit E3) (Alpha-ketoglutarate dehydrogenase complex subunit E3) (alpha-KGDHC subunit E3) (Dihydrolipoamide dehydrogenase) (Dihydrolipoamide:NAD(+) oxidoreductase) (Glycine decarboxylase complex subunit L) (GDC subunit L) (Lipoamide dehydrogenase component of pyruvate dehydrogenase complex) (Pyruvate dehydrogenase complex E3 component) (PDC subunit E3) (PDH complex subunit E3)

Gene: DLDH, LPD1
Organism: Saccharomyces cerevisiae S288C
Interactions: 117
UniProt ID: P09624

Gene Ontology (top 5):
GO:0004148 - dihydrolipoyl dehydrogenase (NADH) activity
GO:0004375 - glycine dehydrogenase (decarboxylating) activity
GO:0004591 - oxoglutarate dehydrogenase (succinyl-transferring) activity
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

484706

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

2

16

High-throughput

0.754

High

484716

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

7

16

Small-scale

0.748

High

484718

ODO1
2-oxoglutarate dehydrogenase, mitochondrial

5

9

Small-scale

0.716

High

484740

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

4

4

High-throughput

0.691

High

484717

KGD4
Alpha-ketoglutarate dehydrogenase subunit 4, mitochondrial

5

0

Small-scale

0.686

High

484746

PREP
Presequence protease, mitochondrial

3

1

High-throughput

0.662

High

484713

ODPX
Pyruvate dehydrogenase complex protein X component, mitochondrial

3

17

High-throughput

0.656

High

484789

GLRX5
Monothiol glutaredoxin-5, mitochondrial

1

1

High-throughput

0.618

High

484730

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

2

0

High-throughput

0.592

High

484702

HSP77
Import motor subunit, mitochondrial

2

1

High-throughput

0.584

High

484712

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

2

6

High-throughput

0.584

High

484704

HSP72
Heat shock protein SSA2

2

5

High-throughput

0.552

High

484705

SSB1
Ribosome-associated molecular chaperone SSB1

2

4

High-throughput

0.549

High

484736

HS104
Heat shock protein 104

2

2

Small-scale

0.521

High

484763

AFG3
Mitochondrial inner membrane m-AAA protease component YTA10

1

0

High-throughput

0.513

High

484703

HSP71
Heat shock protein SSA1

2

5

High-throughput

0.504

High

484767

SSB2
Ribosome-associated molecular chaperone SSB2

2

4

High-throughput

0.504

High

416779

DNLI1
DNA ligase 1

1

1

High-throughput

0.500

High

484728

CDC10
Cell division control protein 10

1

2

High-throughput

0.489

High

484755

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

1

High-throughput

0.489

High

484762

RV167
Reduced viability upon starvation protein 167

1

1

High-throughput

0.489

High

484743

TOR2
Serine/threonine-protein kinase TOR2

1

2

High-throughput

0.481

High

421255

PHR
Deoxyribodipyrimidine photo-lyase, mitochondrial

1

0

High-throughput

0.479

High

484720

RIR3
Ribonucleoside-diphosphate reductase large chain 2

1

0

High-throughput

0.479

High

484725

KC11
Casein kinase I homolog 1

1

0

High-throughput

0.479

High

484757

TYDP1
Tyrosyl-DNA phosphodiesterase 1

1

0

High-throughput

0.479

High

484771

SA185
SIT4-associating protein SAP185

1

0

High-throughput

0.479

High

484792

POLH
DNA polymerase eta

1

0

High-throughput

0.479

High

366894

ATPB
ATP synthase subunit beta, mitochondrial

1

2

High-throughput

0.479

High

484715

MDHM
Malate dehydrogenase, mitochondrial

1

6

Small-scale

0.479

High

484721

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

1

High-throughput

0.479

High

484722

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

3

High-throughput

0.479

High

484731

KAD3
GTP:AMP phosphotransferase, mitochondrial

1

2

High-throughput

0.479

High

484732

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

1

High-throughput

0.479

High

484738

ACPM
Acyl carrier protein, mitochondrial

1

3

High-throughput

0.479

High

484749

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.479

High

484754

LAS1
Protein LAS1

1

1

Small-scale

0.479

High

484764

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

2

High-throughput

0.479

High

484774

ETFB
Probable electron transfer flavoprotein subunit beta

1

3

High-throughput

0.479

High

484778

ALAT1
Alanine aminotransferase, mitochondrial

1

1

High-throughput

0.479

High

484788

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.479

High

484804

ETFA
Probable electron transfer flavoprotein subunit alpha, mitochondrial

1

1

High-throughput

0.479

High

401826

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.458

High

452610

ADH3
Alcohol dehydrogenase 3, mitochondrial

1

0

High-throughput

0.458

High

484719

CBP3
Protein CBP3, mitochondrial

1

0

High-throughput

0.458

High

484724

AIM17
Probable oxidoreductase AIM17

1

0

High-throughput

0.458

High

484729

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

0

High-throughput

0.458

High

484745

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.458

High

484753

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.458

High

484758

PHS
Putative pterin-4-alpha-carbinolamine dehydratase

1

0

High-throughput

0.458

High

484761

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

0

High-throughput

0.458

High

484765

ALDH5
Aldehyde dehydrogenase 5, mitochondrial

1

0

High-throughput

0.458

High

484766

FMP10
Uncharacterized mitochondrial membrane protein FMP10

1

0

High-throughput

0.458

High

484772

COQ7
5-demethoxyubiquinone hydroxylase, mitochondrial

1

0

High-throughput

0.458

High

484776

TOM22
Mitochondrial import receptor subunit TOM22

1

0

High-throughput

0.458

High

484783

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

484784

SHY1
Cytochrome oxidase assembly protein SHY1

1

0

Small-scale

0.458

High

484791

DML1
Protein DML1

1

0

High-throughput

0.458

High

484796

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

High-throughput

0.458

High

484799

YL419
Putative ATP-dependent RNA helicase YLR419W

1

0

High-throughput

0.458

High

484701

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

7

High-throughput

0.457

High

464527

PBS2
MAP kinase kinase PBS2

1

2

High-throughput

0.457

High

484707

SRS2
ATP-dependent DNA helicase SRS2

1

2

High-throughput

0.457

High

484710

ABP1
Actin-binding protein

1

1

High-throughput

0.457

High

484735

RAD16
DNA repair protein RAD16

1

3

High-throughput

0.457

High

484739

CDC12
Cell division control protein 12

1

2

High-throughput

0.457

High

484742

PP12
Serine/threonine-protein phosphatase PP1-2

1

2

High-throughput

0.457

High

484744

RAD54
DNA repair and recombination protein RAD54

1

2

High-throughput

0.457

High

484760

TEM1
Protein TEM1

1

3

High-throughput

0.457

High

484769

RAD26
DNA repair and recombination protein RAD26

1

2

High-throughput

0.457

High

484780

PPP5
Serine/threonine-protein phosphatase T

1

4

High-throughput

0.457

High

484781

BOL2
BolA-like protein 2

1

3

High-throughput

0.457

High

484786

IPI3
Pre-rRNA-processing protein IPI3

1

2

High-throughput

0.457

High

484787

NOP13
Nucleolar protein 13

1

2

High-throughput

0.457

High

484793

KU80
ATP-dependent DNA helicase II subunit 2

1

2

High-throughput

0.457

High

484801

DNLI4
DNA ligase 4

1

1

High-throughput

0.457

High

484751

TOR1
Serine/threonine-protein kinase TOR1

1

2

High-throughput

0.439

High

430743

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

1

Small-scale

0.437

High

484708

CPYI
Carboxypeptidase Y inhibitor

1

3

Small-scale

0.437

High

484711

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

High-throughput

0.437

High

484726

SIS1
Protein SIS1

1

3

High-throughput

0.437

High

484734

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

484756

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

484790

TOM1
E3 ubiquitin-protein ligase TOM1

1

1

High-throughput

0.437

High

484803

DBP10
ATP-dependent RNA helicase DBP10

1

2

High-throughput

0.437

High

484805

CMR1
DNA damage-binding protein CMR1

1

1

High-throughput

0.437

High

394133

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

392053

HSP82
ATP-dependent molecular chaperone HSP82

1

4

High-throughput

0.407

High

484714

BIP
Endoplasmic reticulum chaperone BiP

1

2

High-throughput

0.407

High

484741

HSP7F
Heat shock protein homolog SSE1

1

13

High-throughput

0.407

High

484759

BZZ1
Protein BZZ1

1

0

High-throughput

0.282

High

460932

LTE1
Guanine nucleotide exchange factor LTE1

1

0

High-throughput

0.279

Low

484779

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

1

0

High-throughput

0.279

Low

449377

SPT2
Protein SPT2

1

0

High-throughput

0.261

Low

484709

KSS1
Mitogen-activated protein kinase KSS1

1

0

High-throughput

0.261

Low

484723

DBF2
Cell cycle protein kinase DBF2

1

0

High-throughput

0.261

Low

484727

RAD57
DNA repair protein RAD57

1

0

High-throughput

0.261

Low

484733

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

0

High-throughput

0.261

Low

484737

KNS1
Dual specificity protein kinase KNS1

1

0

High-throughput

0.261

Low

484768

RFC4
Replication factor C subunit 4

1

0

High-throughput

0.261

Low

484770

UTP18
U3 small nucleolar RNA-associated protein 18

1

0

High-throughput

0.261

Low

484777

RL37B
Large ribosomal subunit protein eL37B

1

0

High-throughput

0.261

Low

484782

YGI1
Uncharacterized protein YGL081W

1

0

High-throughput

0.261

Low

484785

BUD32
EKC/KEOPS complex subunit BUD32

1

0

High-throughput

0.261

Low

484795

SEN15
tRNA-splicing endonuclease subunit SEN15

1

0

High-throughput

0.261

Low

484800

RBX1
RING-box protein HRT1

1

0

High-throughput

0.261

Low

484802

YP150
Putative serine/threonine-protein kinase YPL150W

1

0

High-throughput

0.261

Low

268855

MRP10
Small ribosomal subunit protein mS37

1

0

High-throughput

0.249

Low

484747

SMY2
Protein SMY2

1

0

High-throughput

0.249

Low

484748

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

484750

IF4B
Eukaryotic translation initiation factor 4B

1

0

High-throughput

0.249

Low

484752

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.249

Low

484775

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

484798

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

484773

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low

484794

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.232

Low

484797

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025