HitPredict

Interactor 1: PAN2 (A1Z7K9)
PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (EC 3.1.13.4) (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 2) (PAN deadenylation complex subunit 2)
Gene: PAN2

Interactor 2: PAN3 (Q95RR8)
PAN2-PAN3 deadenylation complex subunit PAN3 (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 3) (PAN deadenylation complex subunit 3)
Gene: PAN3

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.839

Property	Details
Experiments	14605208, 22036573, 24880343
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Pan3_PK~UCH_1
Common GO terms	GO:0000289 - nuclear-transcribed mRNA poly(A) tail shortening GO:0000932 - P-body GO:0006397 - mRNA processing GO:0010606 - positive regulation of cytoplasmic mRNA processing body assembly GO:0031251 - PAN complex
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1241 Dm			1 790
+	Hs
		1119424 PAN2_HUMAN (7-1240): 0: 817: 39.43		PAN3_HUMAN (199-788): 0: 548: 44.48
+	Sc
		732626 PAN2_YEAST (45-1240): 1.8e-175: 550: 22.86		PAN3_YEAST (133-784): 4.97e-151: 458: 23.39
+	Nc
		472751 PAN2_NEUCR (47-1239): 4.1e-132: 439: 17.73		PAN3_NEUCR (178-784): 0: 554: 28.50
+	Tt
		101862 PAN2_CHATD (45-1239): 3.15e-140: 457: 17.94		PAN3_CHATD (162-788): 0: 535: 29.45
+	Hs
		1119453 PAN2_HUMAN (7-1240): 0: 817: 39.43		CBP_HUMAN (131-416): 9.48e-10: 64.5: 13.91
+	Hs
		302263 UBP8_HUMAN (359-847): 5e-96: 335: 12.58		SC31A_HUMAN (44-402): 1.32e-14: 80.3: 11.91
+	Hs
		1270763 UBP7_HUMAN (432-1148): 2.23e-92: 324: 10.90		CBP_HUMAN (131-416): 9.48e-10: 64.5: 13.91