HitPredict

Interactor 1: CCL2 (P13500)
C-C motif chemokine 2 (HC11) (Monocyte chemoattractant protein 1) (Monocyte chemotactic and activating factor) (MCAF) (Monocyte chemotactic protein 1) (MCP-1) (Monocyte secretory protein JE) (Small-inducible cytokine A2)
Gene: CCL2

Interactor 2: CCR2 (P41597)
C-C chemokine receptor type 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (Monocyte chemoattractant protein 1 receptor) (MCP-1-R) (CD antigen CD192)
Gene: CCR2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.976

The method score is based on:

Property Details
Experiments 11470772, 8530354, 9312096, 10488147, 9169459, 9115216, 10770925, 9336350, 7759884, 15629146, 11310855, 9837883, 9287323, 10529171
Identification Methods biochemical, experimental interaction detection, competition binding
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains 7tm_1~IL8
Common GO terms GO:0002548 - monocyte chemotaxis
GO:0006935 - chemotaxis
GO:0006954 - inflammatory response
GO:0006959 - humoral immune response
GO:0007259 - cell surface receptor signaling pathway via JAK-STAT
and 8 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 99
Hs

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Last updated: 15 Jul 2024