HitPredict

Interactor 1: CCL5 (P13501)
C-C motif chemokine 5 (EoCP) (Eosinophil chemotactic cytokine) (SIS-delta) (Small-inducible cytokine A5) (T cell-specific protein P228) (TCP228) (T-cell-specific protein RANTES) [Cleaved into: RANTES(3-68); RANTES(4-68)]
Gene: CCL5

Interactor 2: IRF3 (Q14653)
Interferon regulatory factor 3 (IRF-3)
Gene: IRF3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	9891032, 17652396, 12388374
Identification Methods	electrophoretic mobility shift assay, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0042803 - protein homodimerization activity GO:0098586 - cellular response to virus
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 91 Hs			1 427
+	Hs
		1056458 CCL19_HUMAN (17-91): 9.87e-22: 83: 31.17		IRF3_HUMAN (1-427): 0: 604: 100.00
+	Mm
		618899 CCL5_MOUSE (1-91): 1.06e-35: 118: 80.22		IRF8_MOUSE (7-393): 8.11e-150: 433: 28.04
+	Mm
		618889 CCL6_MOUSE (1-90): 3.98e-27: 96.9: 24.30		IRF8_MOUSE (7-393): 8.11e-150: 433: 28.04
+	Hs
		1039468 CCL19_HUMAN (17-91): 9.87e-22: 83: 31.17		IRF5_HUMAN (2-413): 1.48e-143: 420: 29.78
+	Hs
		528273 CCL5_HUMAN (1-91): 4.43e-31: 106: 100.00		IRF7_HUMAN (4-383): 1.71e-105: 323: 26.03
+	Hs
		962721 CCL19_HUMAN (17-91): 9.87e-22: 83: 31.17		IRF9_HUMAN (7-388): 4.4e-113: 338: 23.87
+	Hs
		1273342 CCL19_HUMAN (17-91): 9.87e-22: 83: 31.17		IRF7_HUMAN (4-383): 1.71e-105: 323: 26.03
+	Mm
		547383 CCL5_MOUSE (1-91): 1.06e-35: 118: 80.22		IRF1_MOUSE (1-158): 5.26e-49: 171: 26.99
+	Hs
		500980 CCL5_HUMAN (1-91): 4.43e-31: 106: 100.00		IRF1_HUMAN (1-189): 8.3e-49: 170: 24.23
+	Hs
		501084 CCL19_HUMAN (17-91): 9.87e-22: 83: 31.17		IRF1_HUMAN (1-189): 8.3e-49: 170: 24.23