Protein: NF2L2
Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nrf-2) (Nuclear factor, erythroid derived 2, like 2)

Gene: NF2L2, NFE2L2
Organism: Homo sapiens
Interactions: 200
UniProt ID: Q16236

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001221 - transcription coregulator binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

193341

MAFG
Transcription factor MafG

11

19

Small-scale

0.976

High

1156716

MAFF
Transcription factor MafF

9

20

Small-scale

0.973

High

253409

MAFK
Transcription factor MafK

7

19

Small-scale

0.966

High

429960

JUN
Transcription factor Jun

5

17

Small-scale

0.930

High

617224

ATF4
Cyclic AMP-dependent transcription factor ATF-4

3

9

Small-scale

0.866

High

584099

FOSL2
Fos-related antigen 2

1

20

Small-scale

0.778

High

617169

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

20

Small-scale

0.778

High

921044

FOSB
Protein FosB

1

20

Small-scale

0.778

High

1156708

ZHANG
CREB/ATF bZIP transcription factor

1

6

Small-scale

0.778

High

1121404

KEAP1
Kelch-like ECH-associated protein 1

115

10

Small-scale

0.773

High

1156720

FBW1A
F-box/WD repeat-containing protein 1A

8

20

Small-scale

0.747

High

1156713

FBW1B
F-box/WD repeat-containing protein 11

4

19

Small-scale

0.692

High

1156688

CBP
CREB-binding protein

3

20

Small-scale

0.685

High

161298

ENC1
Ectoderm-neural cortex protein 1

3

11

Small-scale

0.678

High

568560

TNNT1
Troponin T, slow skeletal muscle

4

0

High-throughput

0.668

High

891579

GSK3B
Glycogen synthase kinase-3 beta

3

9

Small-scale

0.651

High

230327

CREB3
Cyclic AMP-responsive element-binding protein 3

1

20

High-throughput

0.647

High

1156662

NFE2
Transcription factor NF-E2 45 kDa subunit

1

20

High-throughput

0.647

High

1156721

NF2L3
Nuclear factor erythroid 2-related factor 3

1

20

High-throughput

0.647

High

1113204

CUL3
Cullin-3

3

10

Small-scale

0.640

High

1156666

PMF1
Polyamine-modulated factor 1

3

0

Small-scale

0.639

High

1156711

CSN7A
COP9 signalosome complex subunit 7a

2

6

Small-scale

0.629

High

1156701

WAC
WW domain-containing adapter protein with coiled-coil

2

7

High-throughput

0.628

High

1156683

DCA11
DDB1- and CUL4-associated factor 11

2

10

Small-scale

0.624

High

282186

MAF
Transcription factor Maf

1

19

Small-scale

0.618

High

853689

MK08
Mitogen-activated protein kinase 8

2

20

Small-scale

0.611

High

246619

KDM1A
Lysine-specific histone demethylase 1A

2

3

High-throughput

0.606

High

251280

CRBL2
cAMP-responsive element-binding protein-like 2

1

1

Small-scale

0.603

High

295335

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

2

Small-scale

0.603

High

628793

TBP
TATA-box-binding protein

1

1

Small-scale

0.603

High

775425

DDIT3
DNA damage-inducible transcript 3 protein

1

8

Small-scale

0.603

High

827801

STAT3
Signal transducer and activator of transcription 3

1

9

Small-scale

0.603

High

832992

ETV6
Transcription factor ETV6

1

20

Small-scale

0.603

High

846913

ETV4
ETS translocation variant 4

1

20

Small-scale

0.603

High

912504

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

1

6

Small-scale

0.603

High

921340

CEBPG
CCAAT/enhancer-binding protein gamma

1

20

Small-scale

0.603

High

1045335

TF65
Transcription factor p65

1

19

Small-scale

0.603

High

1048864

REL
Proto-oncogene c-Rel

1

19

Small-scale

0.603

High

1083495

TEF
Thyrotroph embryonic factor

1

20

Small-scale

0.603

High

142560

IMA3
Importin subunit alpha-3

1

8

Small-scale

0.598

High

1102817

SP140
Nuclear body protein SP140

1

20

Small-scale

0.598

High

1156697

UB2E2
Ubiquitin-conjugating enzyme E2 E2

2

3

Small-scale

0.595

High

321978

NFAT5
Nuclear factor of activated T-cells 5

1

19

Small-scale

0.592

High

622453

ELK1
ETS domain-containing protein Elk-1

1

20

Small-scale

0.592

High

896488

ETV1
ETS translocation variant 1

1

20

Small-scale

0.592

High

1008553

ELF3
ETS-related transcription factor Elf-3

1

20

Small-scale

0.592

High

1156715

BRPF3
Bromodomain and PHD finger-containing protein 3

1

7

Small-scale

0.592

High

372133

MYC
Myc proto-oncogene protein

2

10

Small-scale

0.584

High

584867

NQO1
NAD(P)H dehydrogenase [quinone] 1

2

1

Small-scale

0.584

High

903377

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

2

16

Small-scale

0.584

High

1156673

SYVN1
E3 ubiquitin-protein ligase synoviolin

2

1

Small-scale

0.584

High

283483

TAD2A
Transcriptional adapter 2-alpha

1

10

Small-scale

0.582

High

533940

IRF1
Interferon regulatory factor 1

1

3

Small-scale

0.582

High

578301

ETS2
Protein C-ets-2

1

20

Small-scale

0.582

High

590434

GATA1
Erythroid transcription factor

1

3

Small-scale

0.582

High

920566

ARFP2
Arfaptin-2

1

1

Small-scale

0.582

High

936916

CASP7
Caspase-7

1

3

Small-scale

0.582

High

987667

GRB2
Growth factor receptor-bound protein 2

1

5

Small-scale

0.582

High

1156670

CF299
Cilia- and flagella-associated protein 299

1

1

Small-scale

0.582

High

1156694

CERS2
Ceramide synthase 2

1

2

Small-scale

0.582

High

1156712

LEF1
Lymphoid enhancer-binding factor 1

1

8

Small-scale

0.582

High

179353

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

Small-scale

0.577

High

697128

APEX1
DNA repair nuclease/redox regulator APEX1

1

1

Small-scale

0.573

High

910922

IMA1
Importin subunit alpha-1

1

8

Small-scale

0.568

High

828215

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

8

Small-scale

0.561

High

907447

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

6

Small-scale

0.561

High

1097139

MK07
Mitogen-activated protein kinase 7

1

20

Small-scale

0.561

High

1109453

ATR
Serine/threonine-protein kinase ATR

1

3

Small-scale

0.561

High

1156686

TRI41
E3 ubiquitin-protein ligase TRIM41

1

1

Small-scale

0.561

High

1156692

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

3

Small-scale

0.561

High

1156706

TIGAR
Fructose-2,6-bisphosphatase TIGAR

1

2

Small-scale

0.561

High

1156724

NCOR2
Nuclear receptor corepressor 2

1

11

Small-scale

0.561

High

833630

NAA10
N-alpha-acetyltransferase 10

1

1

Small-scale

0.554

High

461520

HS90A
Heat shock protein HSP 90-alpha

1

10

Small-scale

0.552

High

138697

IMA4
Importin subunit alpha-4

1

8

High-throughput

0.541

High

180831

TIF1A
Transcription intermediary factor 1-alpha

1

20

High-throughput

0.541

High

208845

ZBT24
Zinc finger and BTB domain-containing protein 24

1

9

Small-scale

0.541

High

214836

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

5

Small-scale

0.541

High

571607

IRF2
Interferon regulatory factor 2

1

3

Small-scale

0.541

High

738987

ELF1
ETS-related transcription factor Elf-1

1

20

Small-scale

0.541

High

794502

RBMX
RNA-binding motif protein, X chromosome

1

8

High-throughput

0.541

High

936649

BRPF1
Peregrin

1

7

Small-scale

0.541

High

1102174

ATM
Serine-protein kinase ATM

1

3

Small-scale

0.541

High

1153965

SMAD1
Mothers against decapentaplegic homolog 1

1

15

Small-scale

0.541

High

1156680

SPIC
Transcription factor Spi-C

1

20

Small-scale

0.541

High

1156698

ZN396
Zinc finger protein 396

1

1

Small-scale

0.541

High

1156699

CLIC6
Chloride intracellular channel protein 6

1

3

High-throughput

0.541

High

1156700

ELF4
ETS-related transcription factor Elf-4

1

20

Small-scale

0.541

High

1156714

ELF5
ETS-related transcription factor Elf-5

1

20

Small-scale

0.541

High

556110

CADH1
Cadherin-1

1

0

Small-scale

0.537

High

765553

BMI1
Polycomb complex protein BMI-1

1

3

High-throughput

0.536

High

1156710

E2AK3
Eukaryotic translation initiation factor 2-alpha kinase 3

1

11

Small-scale

0.527

High

520591

RARA
Retinoic acid receptor alpha

1

13

Small-scale

0.515

High

675521

TYY1
Transcriptional repressor protein YY1

1

4

Small-scale

0.515

High

1120172

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

14

High-throughput

0.515

High

1156691

H2B1H
Histone H2B type 1-H

1

6

High-throughput

0.515

High

1156669

ARAID
All-trans retinoic acid-induced differentiation factor

1

0

Small-scale

0.513

High

1156679

PAQR4
Progestin and adipoQ receptor family member 4

1

1

Small-scale

0.512

High

603280

KPCA
Protein kinase C alpha type

1

6

Small-scale

0.501

High

964304

SUMO2
Small ubiquitin-related modifier 2

1

5

Small-scale

0.501

High

991335

SUMO1
Small ubiquitin-related modifier 1

1

5

Small-scale

0.501

High

1086772

BPTF
Nucleosome-remodeling factor subunit BPTF

1

20

Small-scale

0.501

High

188289

HDAC3
Histone deacetylase 3

1

16

Small-scale

0.479

High

211569

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

3

Small-scale

0.479

High

243648

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

17

Small-scale

0.479

High

278359

NCOR1
Nuclear receptor corepressor 1

1

16

Small-scale

0.479

High

295177

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

3

Small-scale

0.479

High

343260

ERR2
Steroid hormone receptor ERR2

1

9

Small-scale

0.479

High

385785

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

8

Small-scale

0.479

High

413919

P53
Cellular tumor antigen p53

1

7

Small-scale

0.479

High

457467

TBB5
Tubulin beta chain

1

8

Small-scale

0.479

High

508040

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

Small-scale

0.479

High

563825

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

Small-scale

0.479

High

572442

DRD2
D(2) dopamine receptor

1

1

Small-scale

0.479

High

572831

NCF1
Neutrophil cytosol factor 1

1

3

Small-scale

0.479

High

662580

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

3

Small-scale

0.479

High

688013

EF1G
Elongation factor 1-gamma

1

3

Small-scale

0.479

High

703945

DUS1
Dual specificity protein phosphatase 1

1

1

Small-scale

0.479

High

712868

CASP1
Caspase-1

1

3

Small-scale

0.479

High

714157

PML
Protein PML

1

7

Small-scale

0.479

High

728262

AKT1
RAC-alpha serine/threonine-protein kinase

1

10

Small-scale

0.479

High

783587

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

10

Small-scale

0.479

High

799154

BRCA1
Breast cancer type 1 susceptibility protein

1

9

Small-scale

0.479

High

808078

CDN1A
Cyclin-dependent kinase inhibitor 1

1

2

Small-scale

0.479

High

853799

MK09
Mitogen-activated protein kinase 9

1

20

Small-scale

0.479

High

873707

GSH1
Glutamate--cysteine ligase catalytic subunit

1

1

Small-scale

0.479

High

873734

GSH0
Glutamate--cysteine ligase regulatory subunit

1

1

Small-scale

0.479

High

909318

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

3

Small-scale

0.479

High

952851

ACTB
Actin, cytoplasmic 1

1

2

Small-scale

0.479

High

979728

H4
Histone H4

1

8

High-throughput

0.479

High

998362

H31
Histone H3.1

1

2

Small-scale

0.479

High

1004621

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

Small-scale

0.479

High

1038303

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

7

Small-scale

0.479

High

1067385

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.479

High

1107755

SQSTM
Sequestosome-1

1

3

Small-scale

0.479

High

1109277

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

2

Small-scale

0.479

High

1109763

HDAC1
Histone deacetylase 1

1

16

Small-scale

0.479

High

1156667

U17L2
Ubiquitin carboxyl-terminal hydrolase 17

1

10

Small-scale

0.479

High

1156668

PAQR3
Progestin and adipoQ receptor family member 3

1

1

Small-scale

0.479

High

1156672

RN111
E3 ubiquitin-protein ligase Arkadia

1

4

Small-scale

0.479

High

1156674

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

1

15

Small-scale

0.479

High

1156675

RBM45
RNA-binding protein 45

1

4

Small-scale

0.479

High

1156677

TRI22
E3 ubiquitin-protein ligase TRIM22

1

1

Small-scale

0.479

High

1156678

HACE1
E3 ubiquitin-protein ligase HACE1

1

13

Small-scale

0.479

High

1156684

PHF10
PHD finger protein 10

1

11

Small-scale

0.479

High

1156685

IASPP
RelA-associated inhibitor

1

6

Small-scale

0.479

High

1156687

HDAC2
Histone deacetylase 2

1

16

Small-scale

0.479

High

1156690

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

14

Small-scale

0.479

High

1156693

OPTN
Optineurin

1

6

Small-scale

0.479

High

1156703

UBP29
Ubiquitin carboxyl-terminal hydrolase 29

1

7

Small-scale

0.479

High

1156704

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

12

Small-scale

0.479

High

1156705

BRD7
Bromodomain-containing protein 7

1

20

Small-scale

0.479

High

1156707

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

Small-scale

0.479

High

1156717

SATB2
DNA-binding protein SATB2

1

2

Small-scale

0.479

High

1156722

DCAF1
DDB1- and CUL4-associated factor 1

1

12

Small-scale

0.479

High

130840

DFFA
DNA fragmentation factor subunit alpha

1

0

Small-scale

0.458

High

583869

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

0

Small-scale

0.458

High

1135689

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

1156681

G45IP
Large ribosomal subunit protein mL64

1

0

Small-scale

0.458

High

1156696

NSL1
Kinetochore-associated protein NSL1 homolog

1

0

High-throughput

0.458

High

1156709

FGF21
Fibroblast growth factor 21

1

0

Small-scale

0.458

High

51081

PKHG3
Pleckstrin homology domain-containing family G member 3

1

1

High-throughput

0.445

High

174764

SPTN2
Spectrin beta chain, non-erythrocytic 2

1

6

High-throughput

0.445

High

229528

NRDC
Nardilysin

1

4

High-throughput

0.445

High

299217

FLOT1
Flotillin-1

1

2

High-throughput

0.445

High

318328

MYO1D
Unconventional myosin-Id

1

3

High-throughput

0.445

High

336434

SVIL
Supervillin

1

3

High-throughput

0.445

High

463107

YES
Tyrosine-protein kinase Yes

1

2

High-throughput

0.445

High

466032

ANXA6
Annexin A6

1

5

High-throughput

0.445

High

467015

DAF
Complement decay-accelerating factor

1

2

High-throughput

0.445

High

536344

MTAP2
Microtubule-associated protein 2

1

6

High-throughput

0.445

High

538969

EPB41
Protein 4.1

1

3

High-throughput

0.445

High

562604

RINI
Ribonuclease inhibitor

1

1

High-throughput

0.445

High

717311

PEBP1
Phosphatidylethanolamine-binding protein 1

1

1

High-throughput

0.445

High

861180

MAP1B
Microtubule-associated protein 1B

1

7

High-throughput

0.445

High

1009653

NGAL
Neutrophil gelatinase-associated lipocalin

1

2

High-throughput

0.445

High

1028781

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

7

High-throughput

0.445

High

1117376

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

8

High-throughput

0.445

High

1124820

FLOT2
Flotillin-2

1

2

High-throughput

0.445

High

1143131

PLEC
Plectin

1

5

High-throughput

0.445

High

1156663

DREB
Drebrin

1

2

High-throughput

0.445

High

1156664

CYTSB
Cytospin-B

1

7

High-throughput

0.445

High

1156665

FA83B
Protein FAM83B

1

1

High-throughput

0.445

High

1156671

MPRIP
Myosin phosphatase Rho-interacting protein

1

5

High-throughput

0.445

High

1156719

COF2
Cofilin-2

1

3

High-throughput

0.445

High

1156695

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

2

Small-scale

0.437

High

127339

LEG8
Galectin-8

1

0

High-throughput

0.426

High

291653

XRP2
Protein XRP2

1

0

High-throughput

0.426

High

472177

TRFM
Melanotransferrin

1

0

High-throughput

0.426

High

483914

HMOX1
Heme oxygenase 1

1

0

High-throughput

0.426

High

522668

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

0

High-throughput

0.426

High

728949

PUR9
Bifunctional purine biosynthesis protein ATIC

1

0

High-throughput

0.426

High

1156676

MISP
Mitotic interactor and substrate of PLK1

1

0

High-throughput

0.426

High

1156682

FBX30
F-box only protein 30

1

0

High-throughput

0.426

High

1156718

XCT
Cystine/glutamate transporter

1

0

High-throughput

0.426

High

1156723

SERC
Phosphoserine aminotransferase

1

0

High-throughput

0.426

High

566685

PDIA4
Protein disulfide-isomerase A4

1

8

High-throughput

0.407

High

1156689

COR2A
Coronin-2A

1

10

High-throughput

0.407

High

155635

ASTN1
Astrotactin-1

1

0

Small-scale

0.249

Low

1156702

K1671
Uncharacterized protein KIAA1671

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025